heads +100%
tails -75%
The expected value is positive: 12.5%If you play five times in parallel you're as likely to make money as to lose money but when you gain you gain 45% on average and when you lose you lose 20% on average. Overall, the expected gain is 12.5%.
If you play five times in sequence you're unlikely to make money (less than 20% probability) but then you make a 300% gain (four heads) or even a 3100% gain (five heads). Overall, the expected gain is 12.5% compounded five times which is 80%.
As the number of coin flips grows it is less and less likely that you lose if you do it in parallel (the expected gain is 12.5% and the distribution of returns converges to that value) and more and more likely that you lose if you do it in sequence (the expected gain is again 12.5% compounded but the distribution of returns is an increasingly skewed lognormal).
Exercise for the reader: take this interesting but simple and well-known fact and make a career out of it from repeating it again, and again, and again, and again, and again, and again, and again...