Hacker News Board Hacker News, browsed like a classic message board
Live data from Hacker News

Alcohol without the hangover – scientists are finding ways

wsj.com

Post reply on HN
Print view View original

131–140 of 297 posts

Re: Alcohol without the hangover – scientists are finding ways

#131

Post by predictabl3 »

jrflowers wrote: post #118
boomskats wrote: post #102

I've had a subscription to David Nutt's Sentia Spirits [0] for a few months, which uses an extract from GABA Labs. I enjoy the mild effect and I do think they're onto something, but I have to mix it as it tastes a bit soapy (that's the red, I've yet to try sentia black). I like the idea that the subscription to Sentia funds the development of Alcarelle (the product mentioned in the article), but the overwhelming reas…

I like how the FAQ has many, many different wordings of “What is in this?” and “How does this work?” with absolutely no information in response to them. It is good to not to have to worry about what is in a thing I’m ingesting or how or if it works at all.

Yeah, four or five clicks and my BS meter is off the charts. Not even so much as a hint as to a keyword to Google for more research. :/

But also, I'm rather intrigued and am doing some more looking now...

EDIT: I can't even tell what the difference between Sentia Red and Black are. I can't tell if one of them actually contains Alcarelle (Which is hard to research since that's GABA Labs' former name). Folks, this is not how you do it.

Re: Alcohol without the hangover – scientists are finding ways

#132

Post by mewpmewp2 »

Nihilartikel wrote: post #122

Reading about this venture to make anf popularize GABA tickling drug without the self limiting ill effects is worrying in the long term. Such things exist, and sure, one is fine.. but one a day for a week and then you are heading for an undescribably hellish withdrawal. I had a brief dalliance with Phenibut for anxiety self medication. It targets GABA receptors, and boy does it work. But read about it in the forums a…

Also used to enjoy Phenibut quite a bit. Felt a bit like Alcohol without the "stupid". Although the onset time wasn't the best to handle and there was huge difference whether I took it on empty stomach in the morning or at some point later in the day. Haven't done it for a while though. Sleep was also amazing. Easy to fall asleep and so sweet. Definitely shouldn't use very frequently like you said. Best to leave at least 2 weeks inbetween. I had periods of using it every day.

Re: Alcohol without the hangover – scientists are finding ways

#133

Post by jrflowers »

predictabl3 wrote: post #131
jrflowers wrote: post #118

Earlier quoted context omitted.

I like how the FAQ has many, many different wordings of “What is in this?” and “How does this work?” with absolutely no information in response to them. It is good to not to have to worry about what is in a thing I’m ingesting or how or if it works at all.

Yeah, four or five clicks and my BS meter is off the charts. Not even so much as a hint as to a keyword to Google for more research. :/ But also, I'm rather intrigued and am doing some more looking now... EDIT: I can't even tell what the difference between Sentia Red and Black are. I can't tell if one of them actually contains Alcarelle (Which is hard to research since that's GABA Labs' former name). Folks, this is n…

It is engineered to appeal to those enlightened enough to move past the petty question of “What am I putting into my body?” to the really important questions like “Was it made in A Lab of some sort?”

Re: Alcohol without the hangover – scientists are finding ways

#134

Post by mabbo »

jdjdjdjdjd wrote: post #96

I have discovered that for me personally, taking magnesium before, during or shortly after having drinks greatly reduces hangovers. I typically get really strong headaches the day after from 2-3 drinks. If I take a 100mg magnesium supplement it is massively reduced. Alcohol depletes magnesium from your body so I guess it counters that.

This is interesting. I take a high absorption magnesium pill daily. I'm not sure what the full reasons are but it seems to improve my sleep apnea and mood (though the mood may be from sleeping better).

But alcohol always seems to counteract that effect.

Re: Alcohol without the hangover – scientists are finding ways

#135

Post by predictabl3 »

Random, but this makes me wonder about Gabapentin. I had a family member take it and apparently acted very erratically, and reports online indicate that it might have similar effects as those boasted by these new drinks.

Can any of the (armchair) pharmacologists shine any light for me? Thanks! I googled some, but I think I'm too inexperienced to even have a foothold to know where to start for researching or really even knowing what I need to understand to guess at this.

Re: Alcohol without the hangover – scientists are finding ways

#136

Post by xmddmx »

SomeRndName11 wrote: post #16

Alcohol is the most boring psychoactive substance ever, even Benadryl is more fun. I really do not understand those who enjoy the experience.

Are you Italian?

I was shocked, about 15 years ago when some Italian friends (who were very drug familiar) said how much they liked that they could buy Benadryl (diphenhydramine) w/o a prescription here in the USA.

I was like "????*" this is not a party drug.

(note: there are folks who use it in massive overdoses as an ACh deliriant [1] but that's not my cup of tea)

https://en.wikipedia.org/wiki/Deliriant

Re: Alcohol without the hangover – scientists are finding ways

#137

Post by thesz »

My personal trainer once told me that athletes that become alcoholics belong to either endurance sports of various kinds or to archer or pistol shooting. The shooting sportsmen use small amounts of alcohol to reduce tremor [1], and small amounts of alcohol became bigger with time.

[1] https://www.jstage.jst.go.jp/article/jhe1972/14/2/14_2_99/_p...

The situation in endurance sports is very different. Very elevated count of mitochondria in cells of endurances athletes make their whole body a liver, basically - these mitochondria organelles get rid of alcohol metabolites during sleep very effectively. Top level endurance athlete drinks to heart content and does not experience a hangover the next day. It is all good and well for some time, athlete can drink everything for a long time, until he has his body physiologically depend on the alcohol, now this endurance athlete is an alcoholic.

I saw an example of alcoholic former endurance athlete once in my life. It was not pretty. He drank anything he can find (or what he brought in) and sleep the work day throughout, delivering nothing.

Re: Alcohol without the hangover – scientists are finding ways

#138

Post by boomskats »

predictabl3 wrote: post #131
jrflowers wrote: post #118

Earlier quoted context omitted.

I like how the FAQ has many, many different wordings of “What is in this?” and “How does this work?” with absolutely no information in response to them. It is good to not to have to worry about what is in a thing I’m ingesting or how or if it works at all.

Yeah, four or five clicks and my BS meter is off the charts. Not even so much as a hint as to a keyword to Google for more research. :/ But also, I'm rather intrigued and am doing some more looking now... EDIT: I can't even tell what the difference between Sentia Red and Black are. I can't tell if one of them actually contains Alcarelle (Which is hard to research since that's GABA Labs' former name). Folks, this is n…

The article mentions Alcarelle trial dates are in a couple of years, it isn't on the market yet. The formulation in Sentia is just herbs, black and red are just flavours.

Re: Alcohol without the hangover – scientists are finding ways

#139

Post by SavageBeast »

mentos wrote: post #120
miduil wrote: post #109

I've been three+ years sober, really can recommend. Life is much different now, things that used to be fun aren't anymore - but I'm making strong connections nevertheless.

Waking up early on a Saturday without a hangover is what I look forward to. I’ll just sit in bed and revel in it now ha

For my own personal experience, the worst part about drinking regularly - and I mean nightly if we're being at all honest - seems to be the people you meet. Having cut down drastically and switched from Volume Drinking kind of venues to Boutique Cocktail Venues I find I'm spending my time around a smaller, higher quality group of people while at the same time drinking less and enjoying my few drinks much more.

[EDIT] I suppose in hanging out with drunks every evening, it normalized the idea of being drunk every night. What I was doing seemed normal because everyone I hung out with was doing the same thing. Thats a good way to start a bad habit.

Re: Alcohol without the hangover – scientists are finding ways

#140

Post by martinald »

darkmarmot wrote: post #127

We could replace alcohol with GHB. Done.

GHB is horrendously addictive and has absolutely brutal withdrawal symptoms. It's drastically worse than alcohol in those two senses.

Plus overdoing it even marginally (as in taking 50-100% more than the "recommended" dose) results in you going into a complete coma, which can happen with alcohol but more like 5-10x.

Post reply on HN