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New study gives clues on why exercise helps with inflammation

sciencedaily.com

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Re: New study gives clues on why exercise helps with inflammation

#51

Post by mandmandam »

jb1991 wrote: post #45
mandmandam wrote: post #43

Earlier quoted context omitted.

> It is unlikely to help you, either, of course I don't think that's true, or fair to say... > there also isn't anything robust to link it to, well, anything. That's not really fair either. Wim Hof has been working with scientists for decades, and there are entire chapters in textbooks about how he has helped develop our understanding of physiology [0]. Read the comments there! See https://www.wimhofmethod.com/scienc…

There is also evidence that Wim Hof's abilities are not related to his lifestyle, as he has a twin brother with similar responses, despite that his brother leads a sedentary lifestyle without any of the practices to cold exposure of his brother. https://en.wikipedia.org/wiki/Wim_Hof#Resistance_to_cold

> There is also evidence that Wim Hof's abilities are not related to his lifestyle

I think you're misinterpreting the point of that study. "A lifestyle with frequent exposures to extreme cold does not seem to affect BAT activity and CIT (cold-induced thermogenesis)" is not the same thing as "Wim Hof's abilities are not related to his lifestyle."

Wim teaches people to do what he does. He has trained people to do some of the things he does, like their blood killing E. Coli (!), or bringing 70+ year olds up mountains in their boxers (!).

I know from personal experience that those methods increase resistance to cold. But you don't need to rely on my testimony, there's video of him teaching people this stuff. It's not a trick.

Re: New study gives clues on why exercise helps with inflammation

#52

Post by ck2 »

zer8k wrote: post #25
ck2 wrote: post #3

Exercise helps with inflammation the same way low-dose naltrexone helps with inflammation. They modulate opioid receptors, increase endorphins and drive down interleukin cytokines. Unfortunately neither actually cure the source of the inflammation, disease etc. https://scholar.google.com/scholar?q=naltrexone+inflammation... https://google.com/search?q=naltrexone+inflammation+cytokine...

There are plenty of cases for exercise curing disease. Metabolic syndrome is basically cured exclusively through diet and exercise until it becomes too late to stop. Physical therapy is exercise and certainly that is curative. Exercise alone took my cholesterol panel from mildly elevated to absolutely normal, lowered my blood sugar, and improved many inflammatory markers. I cannot say the same for naltrexone. Bonus,…

Please don't insult the thousands if not millions of athletes who have either died from incurable diseases or suffer daily from incurable chronic illness.

I personally run every day but it doesn't cure my chronic illness for years now.

Exercise can make you healthier than someone who just sits on the couch but it doesn't by itself cure disease.

Re: New study gives clues on why exercise helps with inflammation

#53

Post by ck2 »

Jacky4Chan wrote: post #4
ck2 wrote: post #3

Exercise helps with inflammation the same way low-dose naltrexone helps with inflammation. They modulate opioid receptors, increase endorphins and drive down interleukin cytokines. Unfortunately neither actually cure the source of the inflammation, disease etc. https://scholar.google.com/scholar?q=naltrexone+inflammation... https://google.com/search?q=naltrexone+inflammation+cytokine...

First time I see someone talking about low-dose naltrexone on HN. There is a video on youtube about someone whose oral cancer was gone after taking it.

There are no serious claims or documentation of LDN curing cancer and that's not it's actual use.

It's used to treat chronic, systemic inflammation and is one of the only "tools in the toolbox" for some very desperate people in long-term pain for years because you can't use things like corticosteroids which are destructive.

There are some cases where it can reduce inflammation well enough and long enough in some people for the body to self-heal where it could not before as the damage was too severe and dysfunctional.

This is a good site for layperson information or use google scholar for actual research

https://ldnresearchtrust.org/what-is-low-dose-naltrexone-ldn

Re: New study gives clues on why exercise helps with inflammation

#54

Post by zer8k »

ck2 wrote: post #52
zer8k wrote: post #25

Earlier quoted context omitted.

There are plenty of cases for exercise curing disease. Metabolic syndrome is basically cured exclusively through diet and exercise until it becomes too late to stop. Physical therapy is exercise and certainly that is curative. Exercise alone took my cholesterol panel from mildly elevated to absolutely normal, lowered my blood sugar, and improved many inflammatory markers. I cannot say the same for naltrexone. Bonus,…

Please don't insult the thousands if not millions of athletes who have either died from incurable diseases or suffer daily from incurable chronic illness. I personally run every day but it doesn't cure my chronic illness for years now. Exercise can make you healthier than someone who just sits on the couch but it doesn't by itself cure disease.

Insult them? Exercise won't cure genetic diseases or cancer.

It absolutely cures metabolic syndrome in all but the most severe cases. But sure, exercise won't fix disease states like high cholesterol, high blood pressure, joint pain (especially brought on by weight), non insulin dependent T2 diabetes, etc.

I never made the claim that it cures every disease. You're an edge case. Congratulations.

Re: New study gives clues on why exercise helps with inflammation

#55

Post by zer8k »

Broken_Hippo wrote: post #32
zer8k wrote: post #25

Earlier quoted context omitted.

There are plenty of cases for exercise curing disease. Metabolic syndrome is basically cured exclusively through diet and exercise until it becomes too late to stop. Physical therapy is exercise and certainly that is curative. Exercise alone took my cholesterol panel from mildly elevated to absolutely normal, lowered my blood sugar, and improved many inflammatory markers. I cannot say the same for naltrexone. Bonus,…

... in a post-scarcity society... So, a world that doesn't exist?

The west is post scarcity. Obesity is an epidemic, diabetes in children is at a record never before seen, and people spend more time sitting still than moving.

Re: New study gives clues on why exercise helps with inflammation

#56

Post by moltar »

simmerup wrote: post #48
moltar wrote: post #17

Earlier quoted context omitted.

I have my own anecdotal evidence to support my own case. My diet is very clean. But at one point I lived in a country with an abundance of fruit and after about 2 years of indulgence I got a toe pain. Didn’t think much of it. Thought I just hit it. But then it lasted almost for a year. That’s when I got worried, did a bunch of reading. Fructose connection was a very clear one, where the traditional connection was act…

That's interesting to hear. How much fruit were you eating?

At this point I believe it’s not only about the total intake per day, but also the frequency. I can eat a lot in one day and get nothing. But if I indulge a few days in a row a trickle of pain will remind me that I need to ease up.

I think it just takes time. Perhaps liver clears out the purine and/or uric acid. From all the stuff I read before about fructose, even unrelated to gout, I think this mostly happens during the periods of fasting. So most likely at night and during deliberate fasts.

But to answer your question. I was eating about half a watermelon a day, plus some other smaller fruit. Then when I moved countries again, to yet another fruit abundant one, but with less watermelon access, I was eating 4-6 peaches per day.

Re: New study gives clues on why exercise helps with inflammation

#57

Post by jb1991 »

mandmandam wrote: post #51
jb1991 wrote: post #45

Earlier quoted context omitted.

There is also evidence that Wim Hof's abilities are not related to his lifestyle, as he has a twin brother with similar responses, despite that his brother leads a sedentary lifestyle without any of the practices to cold exposure of his brother. https://en.wikipedia.org/wiki/Wim_Hof#Resistance_to_cold

> There is also evidence that Wim Hof's abilities are not related to his lifestyle I think you're misinterpreting the point of that study. "A lifestyle with frequent exposures to extreme cold does not seem to affect BAT activity and CIT (cold-induced thermogenesis)" is not the same thing as "Wim Hof's abilities are not related to his lifestyle." Wim teaches people to do what he does. He has trained people to do some…

I am well aware of his methods, I'm just pointing out that someone with identical genetics to him had similar abilities despite never doing any of the stuff Wim does. It is a point worth making.

Re: New study gives clues on why exercise helps with inflammation

#58

Post by simmerup »

moltar wrote: post #56
simmerup wrote: post #48

Earlier quoted context omitted.

That's interesting to hear. How much fruit were you eating?

At this point I believe it’s not only about the total intake per day, but also the frequency. I can eat a lot in one day and get nothing. But if I indulge a few days in a row a trickle of pain will remind me that I need to ease up. I think it just takes time. Perhaps liver clears out the purine and/or uric acid. From all the stuff I read before about fructose, even unrelated to gout, I think this mostly happens durin…

Thank you. That’s less than I thought would be a problem

Re: New study gives clues on why exercise helps with inflammation

#59

Post by winrid »

moltar wrote: post #14
winrid wrote: post #8

It also seems like eating carbs is terrible for inflammation. If I go slightly over normal carb intake my knee/foot will hurt. I have screws in there and I bet it's extra sensitive to inflammation.

Does this happen with any carbs? There’s a strong link with fructose and gout.

You might be on to something. Bagels don't seem to do it but burger buns, with fructose, do. Worth further experimentation.

I doubt I have gout, though, lol. I am a little over 6' and weight 73kg? I always associated gout with diabetes.

Re: New study gives clues on why exercise helps with inflammation

#60

Post by moltar »

winrid wrote: post #59
moltar wrote: post #14

Earlier quoted context omitted.

Does this happen with any carbs? There’s a strong link with fructose and gout.

You might be on to something. Bagels don't seem to do it but burger buns, with fructose, do. Worth further experimentation. I doubt I have gout, though, lol. I am a little over 6' and weight 73kg? I always associated gout with diabetes.

Gout is definitely not limited to diabetes. I’m not overweight, no history of diabetes in the family, and I eat very clean otherwise.

It’s more related to your ability to metabolize fructose which is a rabbit hole of a topic of itself. But a good science based overview is on YouTube. Check Sugar the Bitter Truth video.

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