Live data from Hacker News

New study gives clues on why exercise helps with inflammation

sciencedaily.com

41–50 of 64 posts

Re: New study gives clues on why exercise helps with inflammation

#41
post #14

Earlier quoted context omitted.

Does this happen with any carbs? There’s a strong link with fructose and gout.

While it seems there might be an association, blaming fructose for gout seems just to be a scapegoat for a crappy diet that replaces processed meats with loads of HFCS overall

If you're interested in this Jason Fungs books go into his theory on why fructose is bad for us. His theory is based on the idea that fructose is much like alcohol in our bodies inability to process it properly

Re: New study gives clues on why exercise helps with inflammation

#42

Exercise powers the lymphatic system which increases the rate at which wastes are removed from tissues. https://news.ycombinator.com/item?id=25427090

Exercise correlates with subsequent increased levels of endocannabinoids.

"The anti-inflammatory effect of bacterial short chain fatty acids is partially mediated by endocannabinoids" (2021) https://www.tandfonline.com/doi/full/10.1080/19490976.2021.1... https://www.medicalnewstoday.com/articles/exercise-lowers-in...

"The Endocannabinoid System and Physical Exercise" (2022) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9916354/

What are the relations between exercise and diet (and [health] conscientiousness)?

/? Omega 6:3 ratio (and inflammation): https://www.google.com/search?q=omega+6+3+ratio

Re: New study gives clues on why exercise helps with inflammation

#43
post #21

If you are interested in this topic (inflammation prevention and reduction), take a look at the Wim Hof method (the Iceman). In its simplest form, it consists of two simple techniques: cold exposure and deep breathing with hyper-oxygenation. Anyone can do it, whatever their age or physical condition.

In general, the best thing about this is that it is unlikely to hurt you. It is unlikely to help you, either, of course. At best, this is in the "studies suggest" but there also isn't anything robust to link it to, well, anything.

> It is unlikely to help you, either, of course

I don't think that's true, or fair to say...

> there also isn't anything robust to link it to, well, anything.

That's not really fair either. Wim Hof has been working with scientists for decades, and there are entire chapters in textbooks about how he has helped develop our understanding of physiology [0]. Read the comments there! See https://www.wimhofmethod.com/science for more links. There's a lot of interesting things being learned.

I am biased, because after many years and many attempts to quit tobacco, I quit forever within a week of starting Wim Hof. It was so much less effort. I didn't even spend any money - just YouTube videos and a free app were enough.

I've also gone from someone who hates the winter to someone who quite enjoys it - another huge quality of life bump.

It's real easy to see how effective the method is--you just do it. Maybe it didn't work for you, but ignoring the testimony of thousands of people (and significant actual research) seems like a weird grudg.

0 - https://www.youtube.com/watch?v=A6jqaALpEFM

Re: New study gives clues on why exercise helps with inflammation

#44

Earlier quoted context omitted.

In general, the best thing about this is that it is unlikely to hurt you. It is unlikely to help you, either, of course. At best, this is in the "studies suggest" but there also isn't anything robust to link it to, well, anything.

> It is unlikely to help you, either, of course I don't think that's true, or fair to say... > there also isn't anything robust to link it to, well, anything. That's not really fair either. Wim Hof has been working with scientists for decades, and there are entire chapters in textbooks about how he has helped develop our understanding of physiology [0]. Read the comments there! See https://www.wimhofmethod.com/scienc…

Not to discount those studies, but it's best to look outside of the main website for a balanced view. If there were ten studies showing the Wim Hof method works, and five hundred showing it doesn't, which studies do you think wimhofmethod.com would choose to link to?

This is why you need to find an unconnected source.

For example:

https://www.webmd.com/balance/wim-hof-breathing-technique

Reading through that gives the more expected info: studies are mostly inconclusive and of small sample size.

Re: New study gives clues on why exercise helps with inflammation

#45

Earlier quoted context omitted.

In general, the best thing about this is that it is unlikely to hurt you. It is unlikely to help you, either, of course. At best, this is in the "studies suggest" but there also isn't anything robust to link it to, well, anything.

> It is unlikely to help you, either, of course I don't think that's true, or fair to say... > there also isn't anything robust to link it to, well, anything. That's not really fair either. Wim Hof has been working with scientists for decades, and there are entire chapters in textbooks about how he has helped develop our understanding of physiology [0]. Read the comments there! See https://www.wimhofmethod.com/scienc…

There is also evidence that Wim Hof's abilities are not related to his lifestyle, as he has a twin brother with similar responses, despite that his brother leads a sedentary lifestyle without any of the practices to cold exposure of his brother.

https://en.wikipedia.org/wiki/Wim_Hof#Resistance_to_cold

Re: New study gives clues on why exercise helps with inflammation

#46
This article recapitulates a press release [1], except for one important thing: the latter holds a link to the actual paper [2]. Unfortunately (although not atypically), that paper is behind a paywall, and its abstract does not mention statistical results.

1. https://www.yorku.ca/news/2023/06/15/new-study-gives-clues-o...

2. Murugathasan, Mayoorey, Ardavan Jafari, Amandeep Amandeep, Syed A Hassan, Matthew Chihata, and Ali A. Abdul-Sater. “Moderate Exercise Induces Trained Immunity in Macrophages.” American Journal of Physiology-Cell Physiology, June 12, 2023. https://doi.org/10.1152/ajpcell.00130.2023.

Re: New study gives clues on why exercise helps with inflammation

#47
post #3

Exercise helps with inflammation the same way low-dose naltrexone helps with inflammation. They modulate opioid receptors, increase endorphins and drive down interleukin cytokines. Unfortunately neither actually cure the source of the inflammation, disease etc. https://scholar.google.com/scholar?q=naltrexone+inflammation... https://google.com/search?q=naltrexone+inflammation+cytokine...

First time I see someone talking about low-dose naltrexone on HN. There is a video on youtube about someone whose oral cancer was gone after taking it.

I know a number of people whose cancer was gone after drinking water. Maybe I’ll tell them to put their story on youtube too.

Re: New study gives clues on why exercise helps with inflammation

#48
post #17

Earlier quoted context omitted.

While it seems there might be an association, blaming fructose for gout seems just to be a scapegoat for a crappy diet that replaces processed meats with loads of HFCS overall

I have my own anecdotal evidence to support my own case. My diet is very clean. But at one point I lived in a country with an abundance of fruit and after about 2 years of indulgence I got a toe pain. Didn’t think much of it. Thought I just hit it. But then it lasted almost for a year. That’s when I got worried, did a bunch of reading. Fructose connection was a very clear one, where the traditional connection was act…

That's interesting to hear. How much fruit were you eating?

Re: New study gives clues on why exercise helps with inflammation

#49
post #27
post #14

Earlier quoted context omitted.

Does this happen with any carbs? There’s a strong link with fructose and gout.

Fructose is also highly correlated with NAFLD and other liver diseases. It's probably one of the worst things you can put in your body.

The scientist Lew Cantley has done nice work in this area. He describes how fructose changes liver metabolism, and is linked to some cancers. His concern is mostly large amounts of high fructose corn syrup, and if I recall, one would have to eat unrealsitc amounts of natural fruit to get any of the negative impacts he was looking it.

Re: New study gives clues on why exercise helps with inflammation

#50

Earlier quoted context omitted.

> It is unlikely to help you, either, of course I don't think that's true, or fair to say... > there also isn't anything robust to link it to, well, anything. That's not really fair either. Wim Hof has been working with scientists for decades, and there are entire chapters in textbooks about how he has helped develop our understanding of physiology [0]. Read the comments there! See https://www.wimhofmethod.com/scienc…

Not to discount those studies, but it's best to look outside of the main website for a balanced view. If there were ten studies showing the Wim Hof method works, and five hundred showing it doesn't, which studies do you think wimhofmethod.com would choose to link to? This is why you need to find an unconnected source. For example: https://www.webmd.com/balance/wim-hof-breathing-technique Reading through that gives th…

From your own link:

> Two studies have had significant, promising results. One had a small group of people practice the technique for eight weeks while they prepared to travel to Antarctica. They didn’t find significant chemical changes, but that may be due to the small sample size. They did, however, find that people’s reported stress levels and depressive symptoms had significantly decreased thanks to the technique.

> Another study injected people with E. coli endotoxin. Those who had been practicing the Wim Hof technique had fewer symptoms and better overall immune responses than those who hadn’t.

This isn't a case of there being no there there. More studies would be great but let's not pretend this is woo.

Your link also doesn't show that there are many studies the Wim Hof website are ignoring, so that's a really weird point to try and make. Would you prefer that I link to some other collection of the same exact links?

Post reply on HN