Earlier quoted context omitted.
Yep, they show it's not a senolytic, but I'd like to see an experimental human group (preferably with a dopamine transporter allele making them more prone to placebo-like responses) being given psilocybin and told that it is a senolytic. "Psilocybin treatment led to a dose-dependent decrease in cell cycle arrest markers (p21, p16, and p53) and an increase in markers of DNA replication (phosphorylated-Retinoblastoma p…
Anti-oxidants prevent cell damage caused by reactive oxygen. People thought that's a good thing. But it turns out that can actually promote cancer, because cells expect to be damaged in time, and kill themselves when that happens, and anti-oxidants mess with this mechanism. > Some of the largest clinical trials, in fact, had to be aborted because the patients receiving antioxidants had a higher incidence of cancer th…
There are a ~dozen of studies on dasatinib (anti-cancer drug) + quercetin (senolytic) for curing osteoarthritis in humans, improving heart tissue etc, with dasatinib used as a senolytic. Navitoclax (anti-cancer drug) also used as senolytic in some studies.
In this context it seems that adverse effects from senolytics may be more pronounced in cancer-prone, in younger age or if taking them continuously (not like 5 days per month or so letting some senescent cells to emerge). Yet Sinclair's new venture TallyHealth, for example, are selling a 5 in one capsule, containing apart from other stuff 500 mg quercetin and 100 mg fisetin (senolytics) with an expectation of daily intake. And his 80y old dad is taking senolytics daily with still no cancer.