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OpenWorm – A computational model of C. elegans worm

github.com

11–20 of 159 posts

Re: OpenWorm – A computational model of C. elegans worm

#11

Wow it's amazing how much progress was made on this! a full simulation!!!!

Are you shitting on peoples work just for the sake of shitting on it? edit. this comment seems unpopular, my intent was to defend the worm against trolls :)

Even of the OP was being sarcastic, this type of language is unnecessary.

Re: OpenWorm – A computational model of C. elegans worm

#12

Earlier quoted context omitted.

This is the goal. > Our main goal is to build the world's first virtual organism - an in-silico implementation of a living creature - for the purpose of achieving an understanding of the events and mechanisms of living cells. This blog post is interesting: "Whole Brain Emulation: No Progress on C. elegans After 10 Years" https://www.lesswrong.com/posts/mHqQxwKuzZS69CXX5/whole-brai... As other mentioned in the comment…

Replicating something exactly is a lot harder than making something that does the same thing in a different way. We can build planes that travel far faster than a bird could but that doesn’t mean it’s easy for us to exactly replicate how a bird flies, so I don’t think this says anything about how far away we are from a superintelligence

This. Submarines don't swim like fish, airplanes don't fly like birds and cars don't run like gepards.

Edit: I am surprised at the downvotes. In general, we learn from the nature, but aping it usually proved too difficult and often unpractical at the same time. Do we really want to replicate worm intelligence for practical purposes, or do we want something different?

I would say that a machine which can, say, analyze chemical compounds for their potential biological functions, is a very practical form of "intelligence" and yet very far from any biological intelligence that was ever produced in vivo. Worms cannot do that and even humans struggle with such tasks.

Re: OpenWorm – A computational model of C. elegans worm

#13
302 neurons doesn’t sound impressive to people who may be used to working with 7B+ parameter neural networks. But those neural networks have about as much in common with a biological neuron as a bicycle had with a horse. They can both travel pretty fast but one evolved naturally through over a billion years of harsh natural selection, and the other is a precisely tuned metal machine with a single purpose.

Neurons are similar, they are incredibly sophisticated biological machines, with billions of DNA base pairs controlling their behavior. The emergent behavior of neurons in both biological and AI systems are pretty fascinating

Re: OpenWorm – A computational model of C. elegans worm

#14
post #3
post #2

So is this an exact digital replica of a worm?

How can we exactly replicate something if we don't even know all the laws of physics?

The same way we can simulate the movements of the planets - it will never be exact, but the better we understand it, the more precisely we can simulate it

Re: OpenWorm – A computational model of C. elegans worm

#16

Earlier quoted context omitted.

This is the goal. > Our main goal is to build the world's first virtual organism - an in-silico implementation of a living creature - for the purpose of achieving an understanding of the events and mechanisms of living cells. This blog post is interesting: "Whole Brain Emulation: No Progress on C. elegans After 10 Years" https://www.lesswrong.com/posts/mHqQxwKuzZS69CXX5/whole-brai... As other mentioned in the comment…

Replicating something exactly is a lot harder than making something that does the same thing in a different way. We can build planes that travel far faster than a bird could but that doesn’t mean it’s easy for us to exactly replicate how a bird flies, so I don’t think this says anything about how far away we are from a superintelligence

The bird and the airplane is such an excellent analogy!

Re: OpenWorm – A computational model of C. elegans worm

#17
I like these bottom up approaches, as they demonstrate very well how much we _don't_ know yet about life. Important to mention here Craig Venters minimal cell project syn3.0, where the team synthetically created a livable cell comprising 473 genes. It was done to a large part with trial and error, the function of many of those genes is still not known. A recent review from the same team is to be found at https://doi.org/10.1016/j.cell.2022.06.046 .

Re: OpenWorm – A computational model of C. elegans worm

#18
post #2

So is this an exact digital replica of a worm?

This is the goal. > Our main goal is to build the world's first virtual organism - an in-silico implementation of a living creature - for the purpose of achieving an understanding of the events and mechanisms of living cells. This blog post is interesting: "Whole Brain Emulation: No Progress on C. elegans After 10 Years" https://www.lesswrong.com/posts/mHqQxwKuzZS69CXX5/whole-brai... As other mentioned in the comment…

In defense of the project: they’ve been working a lot over the last 10 years. They recently published what they call a “liquid neural network” where they’ve isolated the neuron structure doing the work. It outperforms CNNs for some niche tasks, and it uses a fraction of the resources.

Re: OpenWorm – A computational model of C. elegans worm

#20

Earlier quoted context omitted.

Replicating something exactly is a lot harder than making something that does the same thing in a different way. We can build planes that travel far faster than a bird could but that doesn’t mean it’s easy for us to exactly replicate how a bird flies, so I don’t think this says anything about how far away we are from a superintelligence

This. Submarines don't swim like fish, airplanes don't fly like birds and cars don't run like gepards. Edit: I am surprised at the downvotes. In general, we learn from the nature, but aping it usually proved too difficult and often unpractical at the same time. Do we really want to replicate worm intelligence for practical purposes, or do we want something different? I would say that a machine which can, say, analyze…

And for some reason it is because somehow life is not able the produce rotating axles?
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