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Tea as Hepatoprotective Agent: A Revisit

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Re: Tea as Hepatoprotective Agent: A Revisit

#11

Post by et2o »

FollowingTheDao wrote: post #8

I have a Partial Purine nucleoside phosphorylase (PNP) deficiency. It is a primary immunodeficiency. I cannot drink tea, and green tea is the wqrst for me since catechins (primarily EGCG) inhibits the PNP enzyme[1] as do quite a few other "healthy" foods like curcumin. It is best to know yourself and if tea makes you feel worse it might not be good for you. [1] https://www.researchgate.net/publication/262327467_Natur…

Thanks for sharing. I’m a doctor. If you don’t mind sharing, out of curiosity how were you diagnosed with this? Not one of the primary immunodeficiencies I see tested, but I’m not a medical geneticist or pediatrician.

Re: Tea as Hepatoprotective Agent: A Revisit

#12

Post by FollowingTheDao »

jerry1979 wrote: post #4
darkclouds wrote: post #2

Do a few grams worth of beta alanine, say up to 10grams and then tell me if you want to drink black tea!

What will happen if someone tries this?

Taking beta-alanine will increase Carnosine synthase activity and probably lead to a depletion of magnesium and/or manganese since they are the co-factors for the enzyme. So this effect will differ based on genetic and nutrition.

https://www.uniprot.org/uniprotkb/A5YM72/entry

Re: Tea as Hepatoprotective Agent: A Revisit

#13

Post by anjel »

gumby wrote: post #3

I've been a dedicated tea drinker since my teens, so this is great news. OTOH what I worry about is oesophageal cancer. Not sure of the prevalence.

https://pubmed.ncbi.nlm.nih.gov/32740163/

Compared to those who consumed 65°C had a more than 1.8-fold higher risk of esophageal squamous cell carcinoma for both green tea and black tea.

Re: Tea as Hepatoprotective Agent: A Revisit

#14

Post by FollowingTheDao »

et2o wrote: post #11
FollowingTheDao wrote: post #8

I have a Partial Purine nucleoside phosphorylase (PNP) deficiency. It is a primary immunodeficiency. I cannot drink tea, and green tea is the wqrst for me since catechins (primarily EGCG) inhibits the PNP enzyme[1] as do quite a few other "healthy" foods like curcumin. It is best to know yourself and if tea makes you feel worse it might not be good for you. [1] https://www.researchgate.net/publication/262327467_Natur…

Thanks for sharing. I’m a doctor. If you don’t mind sharing, out of curiosity how were you diagnosed with this? Not one of the primary immunodeficiencies I see tested, but I’m not a medical geneticist or pediatrician.

Hey doc. Well, I had consistently low WBC counts (leukopenia), skin infections, sinus infections, lung infections (and nodules), as well as recurrent fungal infections. Doctors offered no explanation.

In 2014 I had my genome run on 23andMe and through digging and getting a second genome run I confirmed that I was homozygous for rs1049564 (and other SNPs) in my PNP gene.

I was finally able to push for a PNP activity test which revealed low activity. I do not think the doctors would have ever tested for this.

Here is the paper that persuaded them to do the test: https://www.researchgate.net/figure/Purine-nucleoside-phosph...

Since it is only a partial deficiency it did not cause catastrophic effects as a child, but as I got older it became worse.

Here is a paper talking about the partial deficiency: https://pubmed.ncbi.nlm.nih.gov/32695102/

I also have neurological issues (mood disorder) that I blame on the same deficiency.

Re: Tea as Hepatoprotective Agent: A Revisit

#15

Post by kyleyeats »

FollowingTheDao wrote: post #8

I have a Partial Purine nucleoside phosphorylase (PNP) deficiency. It is a primary immunodeficiency. I cannot drink tea, and green tea is the wqrst for me since catechins (primarily EGCG) inhibits the PNP enzyme[1] as do quite a few other "healthy" foods like curcumin. It is best to know yourself and if tea makes you feel worse it might not be good for you. [1] https://www.researchgate.net/publication/262327467_Natur…

As someone with iron overload who benefits from green tea: It's powerful stuff. One of the only chelators you can get that targets the brain. I have the opposite effect and a green tea addiction.

Re: Tea as Hepatoprotective Agent: A Revisit

#16

Post by amanj41 »

anjel wrote: post #13
gumby wrote: post #3

I've been a dedicated tea drinker since my teens, so this is great news. OTOH what I worry about is oesophageal cancer. Not sure of the prevalence.

https://pubmed.ncbi.nlm.nih.gov/32740163/ Compared to those who consumed 65°C had a more than 1.8-fold higher risk of esophageal squamous cell carcinoma for both green tea and black tea.

As someone who doesn't know much about epidemiology, is 180% relative risk considered scary for something with a fairly low prevalence such as esophageal cancer?

Re: Tea as Hepatoprotective Agent: A Revisit

#17

Post by ricksunny »

FollowingTheDao wrote: post #14
et2o wrote: post #11

Earlier quoted context omitted.

Thanks for sharing. I’m a doctor. If you don’t mind sharing, out of curiosity how were you diagnosed with this? Not one of the primary immunodeficiencies I see tested, but I’m not a medical geneticist or pediatrician.

Hey doc. Well, I had consistently low WBC counts (leukopenia), skin infections, sinus infections, lung infections (and nodules), as well as recurrent fungal infections. Doctors offered no explanation. In 2014 I had my genome run on 23andMe and through digging and getting a second genome run I confirmed that I was homozygous for rs1049564 (and other SNPs) in my PNP gene. I was finally able to push for a PNP activity t…

Wow. I applaud this effort.

Been working on studying pharmacogenetics / pharmacogenomics / toxicogenomics focused on phenols such as catechins in tea. (Activity 'C' of https://docs.google.com/document/d/11f2bzMRbAgCJyoaEmxXKVytl... )

Would love to understand how you researched this, as locating relevant research literature has been challenging.

(updating my user page with contact)

Re: Tea as Hepatoprotective Agent: A Revisit

#19

Post by LegitShady »

jerry1979 wrote: post #4
darkclouds wrote: post #2

Do a few grams worth of beta alanine, say up to 10grams and then tell me if you want to drink black tea!

What will happen if someone tries this?

I don’t know about how interacts with tea, but gym bro forums have talked about itching and anal itching in particular. Maybe the tea makes that worse? No idea.

Re: Tea as Hepatoprotective Agent: A Revisit

#20

Post by karencarits »

Cerium wrote: post #9
jemmyw wrote: post #7

Earlier quoted context omitted.

I usually cool my tea with a splash of milk. But I do then drink it very quickly at an elevated temperature.

Avoid drinking liquids hotter than 140 f. One interesting "test" - take a sip of the liquid, and it does not seem that hot, put your finger in your mouth with the liquid and your finger might feel too hot.

140 degrees Fahrenheit = 60 degrees Celsius
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