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Whole-brain connectome of the fruit fly

codex.flywire.ai

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Re: Whole-brain connectome of the fruit fly

#72

There's lots of very exciting work going on around the fully mapped fruit fly connectome. For example, I'm a CTO of a stealth startup that aims to do for utilitarianism what carbon credits did for environmentalism. We are selling 'utility credits' which translates directly into us simulating trillions and trillions of fruit fly brains in a state of constant orgasmic bliss, which you can then buy to offset any actions…

This is great, but suffers from the same issue as carbon credits in that any secondary market is likely to allow multiple pledging for the same underlying activity. If someone is already simulating millions of orgasmically happy fruit flies, for instance, they can earn utility credits by promising not to deactivate those flies - but how can we verify the same promise hasn't already been extended elsewhere? I think yo…

This is the exact problem that my startup NeuroNFT is trying to solve

NeuroNFT is a platform that uses blockchain technology to generate and trade NFTs (Non-Fungible Tokens) based on the whole brain connectome of the fruit fly.

The core of the platform is a detailed, dynamic model of the fruit fly's brain connectome, mapped with high precision using cutting-edge neuroimaging techniques. Each unique connectome can be tokenized into an NFT and owned by an individual.

These NFTs aren't just pieces of digital art. By leveraging advanced machine learning algorithms and computational models, each NFT can act as a 'brain' for a virtual fruit fly in a digital environment, offering different behavioral patterns based on the unique neuronal configuration represented in the NFT.

This platform serves as a bridge between the worlds of neuroscience, blockchain, and digital art. It provides a novel way for users to learn about neuroscience, while also offering a unique, scientifically rooted form of digital collectible. Moreover, it paves the way for groundbreaking research in understanding brain dynamics and behavior, with users' interactions with their NFTs contributing valuable data to the field.

Re: Whole-brain connectome of the fruit fly

#73
post #28

Earlier quoted context omitted.

If you think about it toughening up our elderly could increase their health and cause them to not need care beds as much. After the initial beatings I mean.

Hmm good point, I didn't think about that - it's a complex issue I guess

We should take a break and go down to the old person right ring.

Re: Whole-brain connectome of the fruit fly

#74
post #58

Didn't quite catch, is this just the first mapping, or are they able to 'execute it'. Like the worm project a few years ago. Where they mapped worm "C. elegans" brain, and was able to put in a simulated environment and watch reactions, and eventually into a robot body. This seems like next step up in complexity, so wondering how far they are along having the 'brain map' execute.

Whole Brain Emulation: No Progress on C. elegans After 10 Years https://www.lesswrong.com/posts/mHqQxwKuzZS69CXX5/whole-brai...

They started publishing again this year! They’ve isolated the neural net and published it as a “liquid neural network”. Check it out, it outperforms CNNs for niche tasks with a fraction of the resources.

Re: Whole-brain connectome of the fruit fly

#77
post #4

Related: * Fruit Fly Brain Observatory https://www.fruitflybrain.org/#/posts/explore_ffbo which lets you visualize and explore datasets * Neurokernel http://neurokernel.github.io/ - open source software which "aims to build an open software platform for the emulation of the entire brain of the fruit fly Drosophila melanogaster on multiple Graphics Processing Units (GPUs)." See also: http://www.bionet.ee.columbia.edu/…

Is it now possible to accurately model the behavior of a C. elegans from its neural connectome?

Re: Whole-brain connectome of the fruit fly

#78
post #46

Would instantiating this network and feeding it random inputs be akin to animal cruelty? Would you run tests on a cat connectome? A human’s? Yours?

Hardly so. A bunch of matrix multipliers is a fully deterministic system, a mechanism in other words. There is nothing in it that can experience pain. Using a truly random RNG device will simply "shake" this mechanism randomly. However with a feedback loop from the mechanism back to the RNG device things become murky, for now we can say that the radioactive rock behind the RNG might experience something, it may even feel like a fruit fly.

Re: Whole-brain connectome of the fruit fly

#79
post #57

Earlier quoted context omitted.

They’re doing a more complex job than a self driving car, with a pinhead sized brain, miniature sensors, and less power than a set of AirPods.

I can't help but think about a fly buzzing against a window as I read this. I don't think the complexity of the tasks are very comparable.

If you put a self driving car in an alien place (like roads with thick glass panels mounted on them) it wouldn't get very far either.

In fact, put a self driving car inside an actual jungle and it would do worse than a fruit-fly inside one of our "concrete" jungles.

Re: Whole-brain connectome of the fruit fly

#80
post #4

Related: * Fruit Fly Brain Observatory https://www.fruitflybrain.org/#/posts/explore_ffbo which lets you visualize and explore datasets * Neurokernel http://neurokernel.github.io/ - open source software which "aims to build an open software platform for the emulation of the entire brain of the fruit fly Drosophila melanogaster on multiple Graphics Processing Units (GPUs)." See also: http://www.bionet.ee.columbia.edu/…

Is it now possible to accurately model the behavior of a C. elegans from its neural connectome?

Nowhere near, and its connectome has been known for decades.
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