I'm pretty excited about this though. I am a veteran Java developer but am tired of being tied to the JVM. Not everyone needs the interop as not everyone is developing in Java/JVM language/platform. I am also geeked about the future of ClojureScript, but not too sure I care much for it in the browser. There is just way too much of a disconnect with everything that is already out there. But, running Clojure on Node seems like a great solution.
I'd like to see more of Clojure written in Clojure someday (sooner than later). Those darned Java exceptions are impossible to decipher in the Clojure context, since there is no context being printed! If you've done even the tiniest of Clojure development, you will know what I am talking about. What we really need first is to see is Clojure's persistent data structures implemented in Clojure, rather than Java (or C#). It would be nice to have this code portable across runtimes (CLR, JVM, Python and perhaps a JavaScript interpreter).
I've been to both Clojure Conj (east coast) and am very excited about Clojure. So, the more ways you can execute Clojure the better (perhaps that will help getting Clojure written in Clojure).