Earlier quoted context omitted.
EVE Online
I believe they shard each sector and their inability to sub-divide their hosting on a sector level has created their infamous timewarped battles?
But there's the bottleneck, because they can only do the calculations of ship movement & actions on a single node. I'm sure it's been optimized to no end as well. IIRC it's written in Python, but that's not going to be the main performance bottleneck.
I have only the smallest of clues about distributed systems, the only way they could scale it up is to somehow make it so they can run a single solar system or cluster of ships on multiple servers, but for that you get the overhead of inter-server communication or you need an asynchronous, eventually-consistent game instead of something realtime.