Soybean oil decreases oxytocin levels in hypothalamus in mice (2020)
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Soybean oil decreases oxytocin levels in hypothalamus in mice (2020)
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Re: Soybean oil decreases oxytocin levels in hypothalamus in mice (2020)
#2[flagged]
Re: Soybean oil decreases oxytocin levels in hypothalamus in mice (2020)
#3[flagged]
In this specific case, I would assume that the finding would apply to pretty much all mammals. Unless of course, the mice organs convert it to a different chemical compound than us and it's that other one that is doing the damage.
Re: Soybean oil decreases oxytocin levels in hypothalamus in mice (2020)
#4tldr: soy oil, and not other oils or other soy products, cause some changes in gene expression in mice that could be linked to various diseases
(not "genetic changes". this is a badly written article)
Re: Soybean oil decreases oxytocin levels in hypothalamus in mice (2020)
#5[flagged]
Yeah, we had cold and hot summers before, I'm not convinced. This is another attack on the crackpot comunity..
In all seriousness it depends on the simalirity of the organs and chemical cycles modeled from mice and men. The bloodbrain barrier and neurons are very similar. And for alot of other systems there are mice bred specifically to recreate human disease simulacra. There are differences and they can be cited when catching a erroneous experiment. https://pubmed.ncbi.nlm.nih.gov/14978070/
Just hinting at the difference as a catch all is insufficient.
Re: Soybean oil decreases oxytocin levels in hypothalamus in mice (2020)
#6tldr: soy oil, and not other oils or other soy products, cause some changes in gene expression in mice that could be linked to various diseases (not "genetic changes". this is a badly written article)
It’s just dumbed down for the common reader - gene expression could very well be simplified as a genetic change when trying to write an ELI5.
Re: Soybean oil decreases oxytocin levels in hypothalamus in mice (2020)
#7[flagged]
[flagged]
Re: Soybean oil decreases oxytocin levels in hypothalamus in mice (2020)
#8This oil probably wasn't cooked, or used for frying. If they can isolate the active ingredient it would be worthwhile checking the heat stability of said ingredient. Maybe soy oil needs to be reduced in uncooked form (such as for salad or dipping oils) but is fine to use for frying. Maybe it's problematic regardless.
If this effect is also present in humans, I wonder whether people who have been using soy oil for many generations have genetically or epigenetically adapted to moderate or eliminate this effect.
Re: Soybean oil decreases oxytocin levels in hypothalamus in mice (2020)
#9[flagged]
In this specific case, I would assume that the finding would apply to pretty much all mammals. Unless of course, the mice organs convert it to a different chemical compound than us and it's that other one that is doing the damage.
This is going to depend on the mode of action of the active agent, and the coordinating molecules and proteins that lead to presence of the active agent affecting expression of these specific genes.
Let's say the small molecule binds a cell-surface receptor causing a cascade that prompts downregulation or upregulation of a transcription factor. The cell-surface receptor binding domain may differ enough between various mammal species that it has less, or more, of an effect in some species than others, and no effect at all in other species.
I think the important part to assume there is something here that probably affects humans in a similar way is the previous linkage of soy oil to obesity and diabetes in humans.
Re: Soybean oil decreases oxytocin levels in hypothalamus in mice (2020)
#10Centuries later after Pax Americana ends historians will be talking about soybean oil like we talk about lead pipes in Rome.