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Metformin shown to prevent long Covid

cidrap.umn.edu

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Re: Metformin shown to prevent long Covid

#131

Post by redeeman »

Fronzie wrote: post #62
pbreit wrote: post #23

In my extended network of 1000+ people, I've heard of 2 that may have "long covid". Are people's experiences different?

Yes, I know of friends and coworkers who have had to change career because they couldn't do their old job anymore. This after a year long recovery. They aren't happy about it, they really want to do their old job, if only they could. Then there are a few more who where home sick for 1 or 2 months. They all seem to have recovered.

is there anything else that happened to them in roughly that period, that they also share and have in common?

Re: Metformin shown to prevent long Covid

#132

Post by thenerdhead »

retrac wrote: post #22
thenerdhead wrote: post #14

Earlier quoted context omitted.

Surely it would be like other antivirals(paxlovid) which have shown to help certain long Covid phenotypes? I.e. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9537824/ > Though not indicated for the treatment of PASC, the treating physician felt that her prolonged nasopharyngeal antigen positivity warranted the treatment. Indeed, the patient’s PASC symptoms fully resolved 3 weeks after completing antiviral treatment

It's not clear it's acting as an antiviral, in the classic sense of directly interfering with the virus, by directly bonding with and neutralizing viral proteins, or supplying lookalike proteins for the cells to make defective viral particles with. Metformin affects glucose metabolism. It may be similar to how metformin seems to help with HIV infection; an immune cell infected with HIV goes into metabolic overdrive a…

Yeah that is fair. I think it is very uplifting that even though we don’t know the mechanism, it may be used for potential long Covid treatment

Re: Metformin shown to prevent long Covid

#133

Post by gumby »

petecooper wrote: post #52

>Now that we're in 2023, and pretty much everyone is either multiply-vaccinated or has had COVID I'm a facilitator for a men's mental health talking group in my county. Sample size is small and not indicative, but there are a few people who are anti-vaccination, have continued to eschew popular science in favour of their trusted researchers, and are now assigning blame to almost any other person's illnesses as caused…

> Aside: one of the (anti-vaccination, anti-establishment) attendees has said that his (anti-vaccination, anti-establishment) trusted expert told him "the banks will collapse" on June 27th (he mentioned Santander specifically). So, now you know.

I have started taking ivermectin to prevent this from happening so don’t worry about your money. You can thank me later.

Re: Metformin shown to prevent long Covid

#134

Post by terminatornet »

collyw wrote: post #112

[flagged]

https://vinayprasadmdmph.substack.com/p/forest-fires-and-n95...

Vinay Prasad said I shouldn't bother putting on a mask when the east coast of the US was blanketed in wildfire smoke.

> First, recognize that some baseline exposure will happen no matter what. Even in your house, you still can smell smoked salmon. The baseline exposure may dwarf any portion remotely modifiable.

I guess none of us should wear masks because you can smell cooking salmon in your house?? Seems like this guy is not that trustworthy

Re: Metformin shown to prevent long Covid

#135

Post by unsupp0rted »

thatguy0900 wrote: post #119
superkuh wrote: post #115

Earlier quoted context omitted.

If Metformin reduces the viral load, it probably does so throughout the entire body. Whereas intramuscular vacccination leads to good protection against serious disease through humoral (body serum) immunity, it does not, unfortunately, provide significant protection to the other immune compartments like the upper respiratory mucosal layer (served by a different set of antibodies than the humoral). So this is good. Th…

I honestly can't imagine taking more covid vaccines. I haven't even thought about covid for a year now.

People with long covid have thought about it a lot during the last year

Re: Metformin shown to prevent long Covid

#136

Post by prottog »

taeric wrote: post #128
sudosysgen wrote: post #125

Earlier quoted context omitted.

The disease and the virus are two different things in standard medical parlance.

I'm not sure I follow, honestly. If you are trying to hold colloquial use to a technical measure, good luck. Even https://en.wikipedia.org/wiki/COVID-19_naming has "While COVID-19 refers to the disease and SARS-CoV-2 refers to the virus which causes it, referring to the "COVID-19 virus" has been accepted." Meaning, that ship sailed. More, https://en.wikipedia.org/wiki/COVID-19 , clearly talks about people having the…

> That does not imply that you only have the disease if you have symptoms.

Not the GP, but I've heard their perspective before from others, i.e. in medicine the symptom is the disease (or that the disease is defined by the symptom). If you have some virus in you that never does anything, you don't have a disease.

Re: Metformin shown to prevent long Covid

#137

Post by Spooky23 »

snemvalts wrote: post #56
gnicholas wrote: post #25

TLDR: > By day 300 of follow-up, 93 (8.3%) of 1,126 participants said they had received a diagnosis of long COVID by a provider. The cumulative incidence of long COVID by day 300 in those who took a 14-day course of metformin was 6.3% (95% confidence interval [CI], 4.2 to 8.2) compared to 10.4% (7.8 to 12.9) in the placebo group, or 39.4% lower. Interestingly, half of the participants in the study (which took place s…

It was also tested only in overweight and obese patients. Pretty much most people are overweight and obese in the US as well, I wouldn't draw any results from this study for people at normal weight.

Metformin is prescribed mostly as a first line type 2 diabetes drug. It’s also used off label for things like PCOS.

So it would make sense that the folks whom benefited tended to be overweight.

Re: Metformin shown to prevent long Covid

#138

Post by FooBarWidget »

taeric wrote: post #121
Izkata wrote: post #110

Earlier quoted context omitted.

> to see if your zero-symptom-life is currently infected No symptoms = not having COVID-19, GP was using the term correctly. Conflating SARS-CoV-2 with COVID-19 is a big annoyance I have with the general usage of "covid".

What? Googling "asymptomatic covid" seems to disagree with this assertion? Even the wikipedia page for it claims: "At least a third of the people who are infected with the virus do not develop noticeable symptoms at any point in time." Has terminology moved on?

"Asymptomatic covid" is defined differently in different countries. They do not always mean "no symptoms".

Re: Metformin shown to prevent long Covid

#139

Post by asynchronous »

sBqQu3U0wH wrote: post #57
petecooper wrote: post #52

>Now that we're in 2023, and pretty much everyone is either multiply-vaccinated or has had COVID I'm a facilitator for a men's mental health talking group in my county. Sample size is small and not indicative, but there are a few people who are anti-vaccination, have continued to eschew popular science in favour of their trusted researchers, and are now assigning blame to almost any other person's illnesses as caused…

Well, I developed heart problems just after getting vaccinated so it's pretty hard for me not to agree when people speculate that some sudden death, severe illness or whatever at a young age may be due to the vaccination. I know I am biased, but how can I not be?

Sorry that happened to you, and equally sorry no one will take your concerns seriously because the narrative has already been decided against you.

Re: Metformin shown to prevent long Covid

#140

Post by taeric »

prottog wrote: post #136
taeric wrote: post #128

Earlier quoted context omitted.

I'm not sure I follow, honestly. If you are trying to hold colloquial use to a technical measure, good luck. Even https://en.wikipedia.org/wiki/COVID-19_naming has "While COVID-19 refers to the disease and SARS-CoV-2 refers to the virus which causes it, referring to the "COVID-19 virus" has been accepted." Meaning, that ship sailed. More, https://en.wikipedia.org/wiki/COVID-19 , clearly talks about people having the…

> That does not imply that you only have the disease if you have symptoms. Not the GP, but I've heard their perspective before from others, i.e. in medicine the symptom is the disease (or that the disease is defined by the symptom). If you have some virus in you that never does anything, you don't have a disease.

Same. I'm not clear on if that is all diseases or not.

I'm also still unsure it matters for this discussion. Especially if we don't have a causal understanding of what moves you from not having symptoms to having symptoms.

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