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Metformin shown to prevent long Covid

cidrap.umn.edu

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Re: Metformin shown to prevent long Covid

#91

Post by chasd00 »

rbanffy wrote: post #74
sBqQu3U0wH wrote: post #57

Earlier quoted context omitted.

Well, I developed heart problems just after getting vaccinated so it's pretty hard for me not to agree when people speculate that some sudden death, severe illness or whatever at a young age may be due to the vaccination. I know I am biased, but how can I not be?

There is a small risk of developing myocarditis after being vaccinated, but the risk of dying of COVID in the US, for instance, was of 1.1% after being diagnosed. I’m really sorry you are going through this. People didn’t have time to better test the vaccines to ensure their safety before having to use them to prevent massive loss of life due to the disease. Perhaps we’ll find ways to alleviate the issues the vaccine…

My little sister developed carditis. She went from not feeling good to emergency heart valve replacement surgery in about 5 days.

Re: Metformin shown to prevent long Covid

#93

Post by contravariant »

gnicholas wrote: post #25

TLDR: > By day 300 of follow-up, 93 (8.3%) of 1,126 participants said they had received a diagnosis of long COVID by a provider. The cumulative incidence of long COVID by day 300 in those who took a 14-day course of metformin was 6.3% (95% confidence interval [CI], 4.2 to 8.2) compared to 10.4% (7.8 to 12.9) in the placebo group, or 39.4% lower. Interestingly, half of the participants in the study (which took place s…

Hmm, going by those confidence intervals this doesn't look significant, or is that just me?

Re: Metformin shown to prevent long Covid

#94

Post by thenerdhead »

cqz wrote: post #41
thenerdhead wrote: post #8

Does it help those with long Covid?

Possible but untested. You may be interested to see this recent study that draws a mechanistic link (broadly, microglial inflammation) between the symptoms of long covid and "chemobrain" following chemotherapy [0]. The authors do suggest treatments proposed to restore cognition post-chemotherapy may also be applicable to long covid, e.g. metformin [1]. [0] https://www.cell.com/cell/fulltext/S0092-8674(22)00713-9 [1]…

Metformin is looking like the aspirin of the 21st century.

Re: Metformin shown to prevent long Covid

#96

Post by r0l1 »

eru wrote: post #87
r0l1 wrote: post #76

Earlier quoted context omitted.

Can't say too much about it. Didn't really follow the whole Covid discussion and just continued my lifestyle. Eating healthy (fresh self-made food), doing sports and looking after a good mental state. Family and my circle did the same. Friends who have been vaccinated got Covid several times. But are also good now... My grandmom (89 years), also unvaccinated, didn't get Covid. Her sister got it (vaccinated). Both hea…

To be fair, Covid was never all that dangerous (in a statistical sense) for relatively young, relatively healthy people. Of course, in the beginning that wasn't clear. And you might still want to get vaccinated, to decrease the likelihood of you passing the virus to your older relatives.

See my other comment. My circle consists of people up to 89 years. Thanks for the hint, but I am not convinced of the vaccine. I'll continue doing my stuff and it's my own responsibility.

Re: Metformin shown to prevent long Covid

#97

Post by r0l1 »

lm28469 wrote: post #83
r0l1 wrote: post #71

Earlier quoted context omitted.

Multiple-vaccinated or has had Covid? Why only those two options? I and a big portion of my circle is unvaccinated, healthy and didn't have Covid.

Unless you've been continually tested every 2 weeks for the past 3 years you might very well have had it asymptomatically

Yeah, that's true.

Re: Metformin shown to prevent long Covid

#98

Post by nradov »

lm28469 wrote: post #83
r0l1 wrote: post #71

Earlier quoted context omitted.

Multiple-vaccinated or has had Covid? Why only those two options? I and a big portion of my circle is unvaccinated, healthy and didn't have Covid.

Unless you've been continually tested every 2 weeks for the past 3 years you might very well have had it asymptomatically

There may be a misunderstanding about terminology here. COVID-19 is the clinical disease caused by the SARS-CoV-2 virus. If you are infected by the virus but asymptomatic then you don't "have Covid".

Re: Metformin shown to prevent long Covid

#99

Post by [deleted] »

hilbertseries wrote: post #47
Sakos wrote: post #46

Earlier quoted context omitted.

I think you're misinterpreting it. The full quote: > Long Covid is looking less like a cloudy mass of speculation and shoulder-shrugging, and more like a problem that medical science can start to unravel, using the tools we already have: > When a disease is too poorly defined, it follows that it is almost impossible to modify either the incidence of that disease or the distribution of its outcomes—that is, unless the…

You’re not paying attention if you think this is the first evidence of long covid. There’s been significant strides towards understanding long covid in terms of microclots and viral persistence. https://cardiab.biomedcentral.com/articles/10.1186/s12933-02... For this pathology long covid can be treated with so called triple therapy for instance https://medhelpclinics.com/uploads/files/anticoagulant-tripl...

[deleted]

Re: Metformin shown to prevent long Covid

#100

Post by nradov »

rbanffy wrote: post #74
sBqQu3U0wH wrote: post #57

Earlier quoted context omitted.

Well, I developed heart problems just after getting vaccinated so it's pretty hard for me not to agree when people speculate that some sudden death, severe illness or whatever at a young age may be due to the vaccination. I know I am biased, but how can I not be?

There is a small risk of developing myocarditis after being vaccinated, but the risk of dying of COVID in the US, for instance, was of 1.1% after being diagnosed. I’m really sorry you are going through this. People didn’t have time to better test the vaccines to ensure their safety before having to use them to prevent massive loss of life due to the disease. Perhaps we’ll find ways to alleviate the issues the vaccine…

You are spreading misinformation. The fatality rate in the US was never as high as 1.1%.

https://www.cdc.gov/coronavirus/2019-ncov/cases-updates/burd...

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