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Does it help those with long Covid?
[0] https://www.cell.com/cell/fulltext/S0092-8674(22)00713-9
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It's continuous. Mean make sperm constantly, and the sperm die constantly. What the study shows is that if there's an effect it would have to be in the short time between the sperm developing and dying
TL; DR Do not take if you're trying to impregnate someone. (Is that the right term? Get pregnant?)
Important to note, it can also cause birth defects in male offspring when taken by fathers. https://med.stanford.edu/news/all-news/2022/03/birth-defects... https://www.acpjournals.org/doi/10.7326/M21-4389
That study doesn't claim causation.
I would definitely take this study seriously, and I don't usually pay a huge amount of attention to population studies.
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Derek Lowe has a good discussion as well: https://www.science.org/content/blog-post/long-covid-shows-c... One thing to point out--this study provides the first really solid evidence that Long Covid actually exists. From Derek Lowe: "An overarching point, though, is made in a valuable commentary in the same issue of the Lancet by Jeremy Samuel Faust: this effect against a placebo control really shows us that there is…
There are literally thousands of studies about long COVID- unless you believe they were all hallucinations by people who shouldn't be in academia, this is very much so not the "first" really solid evidence. I've seen evidence of increased all-cause mortality, arterial stiffness, reduced physical fitness, and much, much more. All of which is in the first place only necessary because a core pillar of healthcare is the…
> Long Covid is looking less like a cloudy mass of speculation and shoulder-shrugging, and more like a problem that medical science can start to unravel, using the tools we already have:
> When a disease is too poorly defined, it follows that it is almost impossible to modify either the incidence of that disease or the distribution of its outcomes—that is, unless the treatment effect is so great, and the true target population so common in the assembled denominator, that any corresponding signal dilutions are offset. The present study suggests that, even with definitions as amorphous and heterogenous as those currently in use for diagnosing long COVID, there was to be found within this study population an ample cohort of individuals with syndromes similar enough that disease incidence could be modified, and metformin appeared to achieve that. Furthermore, the finding that long COVID is modifiable, although here showing prevention, offers hope. . .
This is definitely the first time I've seen anything showing a reliable effect on long Covid. Pretty much everything else I've seen has been a collective shoulder shrug of "well, we saw this, and it's maybe something about Covid, but we really don't know, and we have no idea how to treat this" and a bunch of people saying "it's just a possible side effect of an infection, we've been seeing this for decades". I have no idea how you can dismiss this as something we already know and that this isn't a positive and meaningful step forward.
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There are literally thousands of studies about long COVID- unless you believe they were all hallucinations by people who shouldn't be in academia, this is very much so not the "first" really solid evidence. I've seen evidence of increased all-cause mortality, arterial stiffness, reduced physical fitness, and much, much more. All of which is in the first place only necessary because a core pillar of healthcare is the…
I think you're misinterpreting it. The full quote: > Long Covid is looking less like a cloudy mass of speculation and shoulder-shrugging, and more like a problem that medical science can start to unravel, using the tools we already have: > When a disease is too poorly defined, it follows that it is almost impossible to modify either the incidence of that disease or the distribution of its outcomes—that is, unless the…
https://cardiab.biomedcentral.com/articles/10.1186/s12933-02...
For this pathology long covid can be treated with so called triple therapy for instance
https://medhelpclinics.com/uploads/files/anticoagulant-tripl...
In my extended network of 1000+ people, I've heard of 2 that may have "long covid". Are people's experiences different?
TLDR: > By day 300 of follow-up, 93 (8.3%) of 1,126 participants said they had received a diagnosis of long COVID by a provider. The cumulative incidence of long COVID by day 300 in those who took a 14-day course of metformin was 6.3% (95% confidence interval [CI], 4.2 to 8.2) compared to 10.4% (7.8 to 12.9) in the placebo group, or 39.4% lower. Interestingly, half of the participants in the study (which took place s…
Isn't this the most common demographic?
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There are literally hundreds [1] of literature reviews and meta-analyses about long COVID alone, based on *thousands* of publications about it. Go read some. You don't get to go all "oh idk is there even any credible research about it" as if there's still any reasonable doubt that it's a real condition. There isn't. And fun fact, both depression and "psychosomatic" symptoms have in recent years been increasingly link…
> You don't get to go all "oh idk is there even any credible research about it" as if there's still any reasonable doubt that it's a real condition. There isn't There's a lot of credible-sounding misinformation on this running around. Wouldn't be too harsh on OP.