Hacker News Board Hacker News, browsed like a classic message board
Live data from Hacker News

Metformin shown to prevent long Covid

cidrap.umn.edu

Post reply on HN
Print view View original

31–40 of 195 posts

Re: Metformin shown to prevent long Covid

#31

Post by coolguy1982 »

pbreit wrote: post #23

In my extended network of 1000+ people, I've heard of 2 that may have "long covid". Are people's experiences different?

I know a couple people in their 30’s struggling with long covid. One of them is a startup founder in SF and now has long covid and it’s been really terrible for them and their family. We speak often about it because I was out of work for months unable to function due to intense neurological inflammation. It greatly exacerbated what used to be a mild auto immune condition and I’m still traveling the country to get medical help and working from bed most days.

Re: Metformin shown to prevent long Covid

#32

Post by Llamamoe »

seneca wrote: post #27

[flagged]

There are literally hundreds[1] of literature reviews and meta-analyses about long COVID alone, based on *thousands* of publications about it. Go read some.

You don't get to go all "oh idk is there even any credible research about it" as if there's still any reasonable doubt that it's a real condition. There isn't.

And fun fact, both depression and "psychosomatic" symptoms have in recent years been increasingly linked to underlying physiological pathology and are no longer considered psychogenic symptoms by many, to a point where it's seeming like "psychosomatic" has all along been an excuse to blame people for conditions healthcare has been unable or unwilling to diagnose and treat.

[1] https://scholar.google.com/scholar?hl=en&as_sdt=7%2C39&q=all...

Re: Metformin shown to prevent long Covid

#33

Post by retrac »

seneca wrote: post #27

[flagged]

It would be unusual if it wasn't real in some cases. Fatigue is common following viral infections, in general. It's not that unusual to be left very weak for months after a severe bout of influenza. The herpesviruses can do it too, as will most of the classics like measles, even a common cold if you're particularly unlucky.

Just intuitively, a virus causes damage to the infected tissues. The more severe/long-lasting the infection before recovery, the more likely some of that damage is going to be permanent in the form of scar tissue, rather than normal healing.

It almost certainly is associated with depression. Both in that if there is reduced lung function, etc. it may cause depression. But also in that depression can make an otherwise tolerable physical burden intolerable.

Re: Metformin shown to prevent long Covid

#34

Post by Llamamoe »

bsder wrote: post #29
gnicholas wrote: post #25

TLDR: > By day 300 of follow-up, 93 (8.3%) of 1,126 participants said they had received a diagnosis of long COVID by a provider. The cumulative incidence of long COVID by day 300 in those who took a 14-day course of metformin was 6.3% (95% confidence interval [CI], 4.2 to 8.2) compared to 10.4% (7.8 to 12.9) in the placebo group, or 39.4% lower. Interestingly, half of the participants in the study (which took place s…

Derek Lowe has a good discussion as well: https://www.science.org/content/blog-post/long-covid-shows-c... One thing to point out--this study provides the first really solid evidence that Long Covid actually exists. From Derek Lowe: "An overarching point, though, is made in a valuable commentary in the same issue of the Lancet by Jeremy Samuel Faust: this effect against a placebo control really shows us that there is…

There are literally thousands of studies about long COVID- unless you believe they were all hallucinations by people who shouldn't be in academia, this is very much so not the "first" really solid evidence. I've seen evidence of increased all-cause mortality, arterial stiffness, reduced physical fitness, and much, much more.

All of which is in the first place only necessary because a core pillar of healthcare is the neglect and misattribution of mind-affecting disorders as psychosomatic. I know people after brain injury now being treated for "depression" instead of pituitary dysfunction that occurs in ~80% of cases.

Re: Metformin shown to prevent long Covid

#36

Post by ramraj07 »

pbreit wrote: post #23

In my extended network of 1000+ people, I've heard of 2 that may have "long covid". Are people's experiences different?

You know a 1000 people who will personally tell you if they have a disorder that’s to begin with hard to diagnose and to make worse also hotly debated as even existing at all?

Given everything going against it, if two people actually have told you they have long Covid, what do you reckon the real number is?

Re: Metformin shown to prevent long Covid

#38

Post by MengerSponge »

pbreit wrote: post #23

In my extended network of 1000+ people, I've heard of 2 that may have "long covid". Are people's experiences different?

How would you know? How many in your extended network have Crohn's? Hashimoto's? Diabetes?

A lot of people with long covid don't realize there's a common syndrome for their symptoms. And of those who do know, most people don't broadcast their experiences with a long-term disability.

Re: Metformin shown to prevent long Covid

#39

Post by JumpCrisscross »

8note wrote: post #21
slim wrote: post #16

Earlier quoted context omitted.

what does that mean ? is there a season for sperm development ?

It's continuous. Mean make sperm constantly, and the sperm die constantly. What the study shows is that if there's an effect it would have to be in the short time between the sperm developing and dying

TL; DR Do not take if you're trying to impregnate someone. (Is that the right term? Get pregnant?)

Re: Metformin shown to prevent long Covid

#40

Post by JumpCrisscross »

Llamamoe wrote: post #32
seneca wrote: post #27

[flagged]

There are literally hundreds [1] of literature reviews and meta-analyses about long COVID alone, based on *thousands* of publications about it. Go read some. You don't get to go all "oh idk is there even any credible research about it" as if there's still any reasonable doubt that it's a real condition. There isn't. And fun fact, both depression and "psychosomatic" symptoms have in recent years been increasingly link…

> You don't get to go all "oh idk is there even any credible research about it" as if there's still any reasonable doubt that it's a real condition. There isn't

There's a lot of credible-sounding misinformation on this running around. Wouldn't be too harsh on OP.

Post reply on HN