Serotonin booster leads to increased functional brain connectivity

>This just comes across as a last-ditch effort to try to prove me wrong lol

Yeah, because all the other ironic examples (amounting to "just stop having the problem") you non-ironically agreed to variations of, were such well established solutions...

hmmm... although it is a logical fallacy, statistics show that the margin of error based on successful previous observations is smaller than the margin of error base on no previous observations.

In other words, although it is not certain that an observation will be accurate, the chances of an accurate observation are increased by someone who has previous success.

Smart people - who have observed things correctly - might have fewer errors observing and predicting.

(but I'm old and silly, frequently suffering from Gell-Mann Amnesia)

Ooh, ritalin is a fascinating and intricate one. I also have severe ADHD, and I've also noticed this somewhat paradoxical fact about ritalin.

I think the comparison between ritalin and strattera can be quite illuminating here.

Ritalin is an NDRI(norepinephrine and dopamine reuptake inhibitor). It binds to and and inhibits DAT(dopamine transporter) and NET(norepinephrine transporter). This causes neurotransmitter to remain in the synaptic cleft for longer. It also acts on some interesting serotonin receptors.

Now, for ADHD treatment, you typically want to increase dopaminergic neurotransmission specifically in the prefrontal cortex(PFC), which is the part of the brain that's underdeveloped in ADHD.

Stranglely there's very little DAT in the PFC, but it turns out NET also works for dopamine, and NET does what DAT would normally do in this part of the brain. So inhibition of NET is clearly crucial to ritalin working.

This is where strattera comes in. Strattera is a selective inhibitor for NET with no appreciable effect on DAT. So strattera ups dopamine in the PFC, but not in the brain's reward centre. Helps your ADHD, but it doesn't make you high.

And the interesting thing with strattera is that it sort of has this same property that SSRIs have in that it has a delayed onset of effect Where it gets more and more effective over time. I believe there are some studies tying this to rewiring in the PFC, but don't quote me on that.

But ritalin literally works starting with the first dose. You get that sudden motivation to actually do stuff and so on.

So I actually think ritalin has at least two different modes of operation, one acute and one chronic. And it's the latter that's doing all the real work, the former is just a transitory kick in the butt, so to speak.

I hope that rant made sense!

In the sprawling expanse of online forums, an intriguing display of intelligence often takes shape. It's a labyrinthine network where discerning authentic insight from empty repetition is a challenge. A platform where individuals, often unknown to each other, put forth their assertions and speculations under the guise of knowledge.

A peculiar phenomenon plays out under the hushed light of device screens—a grand theater where the lines between jesters and scholars blur. Filled with words mimicking wisdom, these digital performers garner attention and agreement, even when their insights are more a reflection of someone else's knowledge. It's a dance of self-deception where individuals flaunt expertise in various disciplines, leaving the audience to disentangle fact from illusion.

Yet, amidst this tumult, some oasis of genuine discourse exists. There are those who engage in meaningful, respectful conversation, offering a refreshing contrast to the often convoluted discourse. However, even this refuge isn't devoid of potential pitfalls as seemingly intelligent and polite conversation may house misinformation and misinterpretation.

Digital interlocutors, fueled by a heightened sense of self-importance, often propagate misinformation convincingly. Their illusion of authority can be shattered by the discerning who dare to look beyond the performance and expose the reality underneath.

This leads us to an intriguing hypothesis: Are these digital scribes uncannily similar to artificial intelligence language models, mimicking not only the language but also the decision-making processes of humans? This analogy paints a rather abstract picture. Have we, in our quest for dialogue and connection, birthed a race of digital echo chambers that speak with the voice of authority but may lack the depth of true understanding?

As this digital spectacle unfolds, we're left to ponder the performances we've witnessed. It is an ongoing show where the actors might be unaware of their roles and the audience might not discern the plot. The landscape of online forums seems to mirror our inherent struggle to separate truth from fiction, leaving us to navigate the often blurry line between the two.

I should have looked harder, apologies! :) Commented in a rush.