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Serotonin booster leads to increased functional brain connectivity

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Re: Serotonin booster leads to increased functional brain connectivity

#181

Post by vanderZwan »

dustingetz wrote: post #70
vanderZwan wrote: post #38

Earlier quoted context omitted.

I can't speak for any other illness mentioned, but from what I've been told as someone with ADHD a significant part of the "nature" side of it is caused by either reduced serotonin sensitivity, a faster-than-normal re-uptake of serotonin whenever it gets released (meaning it doesn't get to do its job), or some other disruption of how serotonin is supposed to function in the brain. So when it's caused by reduced sensi…

do you mean dopamine?

Oh, did I mix up those two again? I'm pretty sure both are involved though.

Re: Serotonin booster leads to increased functional brain connectivity

#182

Post by moneywoes »

PragmaticPulp wrote: post #178
pr0zac wrote: post #73

I’ll probably be downvoted for pointing this out but I feel like it’s important. 90% of the comments at the time of my posting this are great examples of the logical fallacy a lot of intelligent people fall into where they think their intelligence in one area means they’re qualified to make assessments or reach conclusions in fields outside of their own. This would be the same error in judgment that’s turned the noot…

The health podcast industry is making this problem even worse. Many people consume content like Huberman’s podcast and assume he’s an expert because he speaks so confidently and at such lengths. Yet Huberman’s podcasts are well known to contain a lot of errors on very basic concepts and extreme exaggerations. He appears to well-versed in topics related to his domain of study, albeit with exaggerations of his findings…

> Yet Huberman’s podcasts are well known to contain a lot of errors on very basic concepts and extreme exaggerations

Is there a list?

Re: Serotonin booster leads to increased functional brain connectivity

#183

Post by PragmaticPulp »

For anyone coming to this comment section in hopes of understanding this further: This comment section is full of misinformation and discourse about drugs that are completely unrelated to what’s discussed in the article.

Serotonin isn’t a singular system in the brain. Psychedelics generally don’t interact with the receptor mentioned in this article (5-HT4) so all of the anecdotes talking about LSD or mushrooms do not apply to this story at all. Serotonin agonists are not interchangeable and have very different effects depending on their targets.

The drug in this study (Prucalopride) has been noted to influence depression symptoms positively for some time. However, it has also been noted to be associated with suicidal ideation in some vulnerable populations. This is an emergent area of research and absolutely should not be taken as a suggestion for self-treatment.

If that’s not enough to convince you to not self-experiment, you should know that Prucalopride is primarily used as a constipation treatment. If you take it, you’re going to have some dramatic bowel effects.

Please understand that these articles are interesting, but HN comments about anything related to psychedelics, serotonin, or dopamine are often quite far from the mark (despite being very confident in their delivery).

Re: Serotonin booster leads to increased functional brain connectivity

#184

Post by candiodari »

maleldil wrote: post #100
dumpsterdiver wrote: post #95

Earlier quoted context omitted.

Are they really that intelligent if they truly believe that their expertise can be applied to any field? Imo, understanding your own limitations is a form of intelligence that is very important.

You could have specialised intelligence and be clueless about everything else, including evaluating your ability. Intelligence doesn't beget humility. Nobel disease is a thing[0]; Linus Pauling is possibly the most famous example and the cause of people taking too much vitamin C until this day. [0] https://en.wikipedia.org/wiki/Nobel_disease

This is in contrast to research on the subject. Intelligence is one of the very few psychological properties that's universal. A smart person is smart. Doesn't matter the subject.

Of course that doesn't mean they know everything. It means that either they are smart and know a lot about a field OR can become knowledgeable a lot about a field in relatively little time.

This does also mean the reverse: expertise in a field does not actually require intelligence. It just works a lot faster if you have it. But being "dumb" does not place an upper limit on how capable you can be in a field, you'll just have to work longer to get there.

Re: Serotonin booster leads to increased functional brain connectivity

#185

Post by pgt »

pr0zac wrote: post #73

I’ll probably be downvoted for pointing this out but I feel like it’s important. 90% of the comments at the time of my posting this are great examples of the logical fallacy a lot of intelligent people fall into where they think their intelligence in one area means they’re qualified to make assessments or reach conclusions in fields outside of their own. This would be the same error in judgment that’s turned the noot…

Instead of appealing to authority, could you please try to refute some of the logical fallacies that you claim are being made in the comments?

Re: Serotonin booster leads to increased functional brain connectivity

#186

Post by Vrondi »

ZunarJ5 wrote: post #54
ben_w wrote: post #33

Earlier quoted context omitted.

100-150 years ago we were using heroin, cocaine, and morphine for such things as cough syrups, hay fever, cola. Ancient Romans used cannabis and opium for insomnia and earaches. Wild animals get drunk on rotten fruit, cats stone themselves on catnip. So you're not wrong to wonder why people take stuff, but none of that's new .

Just because it's one of my favourites, we even have evidence of it in rock art: https://www.atlasobscura.com/articles/psychedelic-mushroom-a...

Fascinating. Here's a different article with a photo: https://www.openculture.com/2021/01/algerian-cave-paintings-...

Re: Serotonin booster leads to increased functional brain connectivity

#187

Post by PragmaticPulp »

peet2521 wrote: post #141

I came to the comment section to mention other seratonergic drugs that do something similar to what the study mentions. Psilocin is a serotonin 2A agonist, LSD is a 1A agonist (according to a quick google search), and this new drug works on "4" receptors. All of which seem to have similar beneficial therapeutic effects when used properly. In general, I'm very excited to see drugs like these being researched, includin…

> I came to the comment section to mention other seratonergic drugs that do something similar to what the study mentions. Psilocin is a serotonin 2A agonist, LSD is a 1A agonist (according to a quick google search), and this new drug works on "4" receptors. All of which seem to have similar beneficial therapeutic effects when used properly.

Serotonin receptors are not interchangeable at all.

5-HT2A and 5-HT4 receptors have completely different effects and functions. You can’t suggest that drugs that work on one are similar to the other.

They are nothing alike.

Re: Serotonin booster leads to increased functional brain connectivity

#188

Post by PragmaticPulp »

cvccvroomvroom wrote: post #5

Don't get too excited. It's likely to also cause cardiac issues like cisapride. Arrhythmia and 5-HT2B agonism are the worries.

No, Prucalopride was specifically studied for cardiac complications.

Why is there so much rampant misinformation in this comment section when the facts are a simple Google search away?

Re: Serotonin booster leads to increased functional brain connectivity

#189

Post by vbtemp »

pr0zac wrote: post #73

I’ll probably be downvoted for pointing this out but I feel like it’s important. 90% of the comments at the time of my posting this are great examples of the logical fallacy a lot of intelligent people fall into where they think their intelligence in one area means they’re qualified to make assessments or reach conclusions in fields outside of their own. This would be the same error in judgment that’s turned the noot…

It's kind of like how we all have our favorite podcasts to learn about new things. When it's a topic we don't know much about it's so interesting and we learn so much, but when it's a topic we're experts in, we get exasperated about how inaccurate or misleading it is.

Re: Serotonin booster leads to increased functional brain connectivity

#190

Post by tnel77 »

bedobi wrote: post #166
pr0zac wrote: post #73

I’ll probably be downvoted for pointing this out but I feel like it’s important. 90% of the comments at the time of my posting this are great examples of the logical fallacy a lot of intelligent people fall into where they think their intelligence in one area means they’re qualified to make assessments or reach conclusions in fields outside of their own. This would be the same error in judgment that’s turned the noot…

> intelligent people fall into where they think their intelligence in one area means they’re qualified to make assessments or reach conclusions in fields outside of their own you're describing 99.99% of hackernews, lol (and I'm not even sure people here are that intelligent in the first place) (in case anyone is reading this thinking I'm saying I'm intelligent, rest assured I'm not)

I like HackerNews because the conversations are mostly intelligent and polite. Not always, but it’s far better than my experience with Twitter and Reddit.
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