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Serotonin booster leads to increased functional brain connectivity

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Re: Serotonin booster leads to increased functional brain connectivity

#21

Post by ljf »

lynx23 wrote: post #18
ljf wrote: post #3

About 2 years ago I wasn't in a good place. My wife had been ill for a year, I found the lockdown hard (though I agreed with them), and I was struggling at my job. I wasn't sleeping well and was settling into a funk. I started taking 5-htp [0] every evening before bed - and over about a month I felt like a changed man. It took about 6 months to fully sort my sleep out and get my head back to where I wanted it, and to…

[flagged]

My poor sleep and stresses started well before Covid, but definitely came to a head then, combined with my wife's illness from long covid.

After seeing what covid did to my wife and others with long covid, plus friends who lost parents etc., I remain fully supportive of the lockdowns here in the UK - though as I've said here before:

the lockdowns were not about saving the old, but about keeping as many of the infirm out of hospital as possible, so that people wouldn't die from broken arms or childbirth.

Re: Serotonin booster leads to increased functional brain connectivity

#24

Post by mtlmtlmtlmtl »

phreeza wrote: post #12

A note for people not familiar with the terminology - "functional connectivity" is a specific technical term that really just means temporal correlation between brain areas, as opposed to "structural connectivity" which refers to the actual neural pathways that are formed between brain areas. If you rephrase the headline as "Serotonin booster leads to increased correlation between activity in different brain areas" i…

The main reason it's not too exciting to me is much simpler. They tested it for 6 days. You can do all sorts of wonderful stuff with a drug for a few days. But for most drugs, the effects simply cease if you keep taking it due to tolerance.

And there doesn't seem to be a huge amount of leeway to up the dose either because it's a laxative.

Re: Serotonin booster leads to increased functional brain connectivity

#25

Post by alwayslikethis »

ljf wrote: post #3

About 2 years ago I wasn't in a good place. My wife had been ill for a year, I found the lockdown hard (though I agreed with them), and I was struggling at my job. I wasn't sleeping well and was settling into a funk. I started taking 5-htp [0] every evening before bed - and over about a month I felt like a changed man. It took about 6 months to fully sort my sleep out and get my head back to where I wanted it, and to…

One warning about 5-HTP here. It seems that it can be potentially cardiotoxic at higher doses, or so as I read.

Re: Serotonin booster leads to increased functional brain connectivity

#26

Post by carlmr »

scns wrote: post #14
tpm wrote: post #9

Earlier quoted context omitted.

With magnesium it's more the specific salts that are laxative. Like the oxide which is both a laxative and has a low bioavailability. Citrate in huge doses is used as a laxative too. On the other hand, I have good experience with the orotate. Lactate and gluconate should be good too.

Bisglycinate is supposed to have the highest bioavailability.

And IME zero laxative effects. Citrate in normal doses is also okay

Re: Serotonin booster leads to increased functional brain connectivity

#29

Post by TheSpiceIsLife »

tpm wrote: post #9
cvccvroomvroom wrote: post #6

Earlier quoted context omitted.

Magnesium is too, to a degree. With age, this is often a good property. There are plenty of opioid analogues to decrease it safely.

With magnesium it's more the specific salts that are laxative. Like the oxide which is both a laxative and has a low bioavailability. Citrate in huge doses is used as a laxative too. On the other hand, I have good experience with the orotate. Lactate and gluconate should be good too.

Magnesium amino acid chelate is best for most, especially magnesium di-glycinate.
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