Serotonin booster leads to increased functional brain connectivity
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Re: Serotonin booster leads to increased functional brain connectivity
#2>This provides further evidence that prucalopride is having an effect in areas of the brain that improve cognitive function – both by increasing and reducing connectivity between specific brain regions as required.”
Altering the functional connectivity of the circuits is not necessarily correlated to "boosting" the memory.
Re: Serotonin booster leads to increased functional brain connectivity
#3About 2 years ago I wasn't in a good place. My wife had been ill for a year, I found the lockdown hard (though I agreed with them), and I was struggling at my job.
I wasn't sleeping well and was settling into a funk. I started taking 5-htp [0] every evening before bed - and over about a month I felt like a changed man.
It took about 6 months to fully sort my sleep out and get my head back to where I wanted it, and to be honest it's only been in the last 6 months that I feel like I'm totally firing on all cylinders.
But I personally feel like 5-htp had a massive impact in that. I only took it daily for about 6 months, then more sporadically for another 6 months, and now don't take it at all (but focus on other boosters like walking, litter picking, swimming, seeing friends etc.)
Re: Serotonin booster leads to increased functional brain connectivity
#4Too bad it's also a laxative.
Re: Serotonin booster leads to increased functional brain connectivity
#5Don't get too excited. It's likely to also cause cardiac issues like cisapride. Arrhythmia and 5-HT2B agonism are the worries.
Re: Serotonin booster leads to increased functional brain connectivity
#6Too bad it's also a laxative.
Magnesium is too, to a degree. With age, this is often a good property.
There are plenty of opioid analogues to decrease it safely.
Re: Serotonin booster leads to increased functional brain connectivity
#7Too bad it's also a laxative.
Magnesium is too, to a degree. With age, this is often a good property. There are plenty of opioid analogues to decrease it safely.
Mag isn't too bad, I believe you also get acclimated to it (haven't taken it in a while).
IME it's not much different from having a fiber-heavy diet.
Re: Serotonin booster leads to increased functional brain connectivity
#8About 2 years ago I wasn't in a good place. My wife had been ill for a year, I found the lockdown hard (though I agreed with them), and I was struggling at my job. I wasn't sleeping well and was settling into a funk. I started taking 5-htp [0] every evening before bed - and over about a month I felt like a changed man. It took about 6 months to fully sort my sleep out and get my head back to where I wanted it, and to…
As with anything like this (especially anecdotal), how much did you take each day, and did you change anything else over the same period ?
Re: Serotonin booster leads to increased functional brain connectivity
#9Too bad it's also a laxative.
Magnesium is too, to a degree. With age, this is often a good property. There are plenty of opioid analogues to decrease it safely.
With magnesium it's more the specific salts that are laxative. Like the oxide which is both a laxative and has a low bioavailability. Citrate in huge doses is used as a laxative too. On the other hand, I have good experience with the orotate. Lactate and gluconate should be good too.
Re: Serotonin booster leads to increased functional brain connectivity
#10Don't get too excited. It's likely to also cause cardiac issues like cisapride. Arrhythmia and 5-HT2B agonism are the worries.
Neither of them are 5-HT2b agonists, the cardiac effects of cisapride are due to inhibition of the cardiac HERG K+ channel, but apparently this does not seem to be as of an issue with prucalopride [1].
[1] https://onlinelibrary.wiley.com/doi/10.1111/j.1365-2036.2012...