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Taurine deficiency as a driver of aging

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Re: Taurine deficiency as a driver of aging

#261

Post by theobromananda »

throwaway2037 wrote: post #198
robwwilliams wrote: post #133

Solid study, but the core results are based on a single genotype of mouse — C57BL/6J. Imagine a clinical study of longevity using 120 clones of you or me. Taurine may be effective at extending lifespan and healthspan of C57BL/6J mice but will it work as well using genetically diverse mice such as the UM-HET3 mice? Like humans, the UM-HET3 mice are genetically diverse (they segregate for about 11.5 million sequence va…

By the way: A 16 oz can of Monster contains 2 grams of taurine. My first thought when I reading your post (before I finished): How many grams of taurine per kilogram of body weight were used in the trial? I found: Taurine supplementation increases the life span of mice To determine whether the observed drop in taurine concentration contributes to aging, we orally administered control solution or taurine at 1000 mg pe…

Human-mouse conversion ratio is 1:12.3, so about 6g a day. I easily eat a gram if I drink a ton of coffee.

Re: Taurine deficiency as a driver of aging

#263

Post by KptMarchewa »

tiffanyg wrote: post #173
robwwilliams wrote: post #133

Solid study, but the core results are based on a single genotype of mouse — C57BL/6J. Imagine a clinical study of longevity using 120 clones of you or me. Taurine may be effective at extending lifespan and healthspan of C57BL/6J mice but will it work as well using genetically diverse mice such as the UM-HET3 mice? Like humans, the UM-HET3 mice are genetically diverse (they segregate for about 11.5 million sequence va…

> By the way: A 16 oz can of Monster contains 2 grams of taurine. And at least 50%+ of the "added sugar" recommendation(s) for an entire day (depending on whether you look at FDA, AHA, etc. guidelines). You make good points, for sure, and I appreciate your comment and insights. But, "sugar" is definitely an issue with a lot of current foods. Carbohydrates are crucial building blocks, biochemically. However, there are…

There are 0 sugar versions of monster

Re: Taurine deficiency as a driver of aging

#264

Post by amarant »

spiderice wrote: post #207
throwaway2037 wrote: post #198

Earlier quoted context omitted.

By the way: A 16 oz can of Monster contains 2 grams of taurine. My first thought when I reading your post (before I finished): How many grams of taurine per kilogram of body weight were used in the trial? I found: Taurine supplementation increases the life span of mice To determine whether the observed drop in taurine concentration contributes to aging, we orally administered control solution or taurine at 1000 mg pe…

There is a comment much further down the page explaining how dosages don't translate across species like this. Apparently the human equivalent would be 6.48 grams per day.

Regardless of the humans body weight? I find that curious if so!

Could you post a link to the comment you mentioned? I scrolled down but didn't find it... :(

Re: Taurine deficiency as a driver of aging

#265

Post by mtlmtlmtlmtl »

AtlasBarfed wrote: post #202
robwwilliams wrote: post #133

Solid study, but the core results are based on a single genotype of mouse — C57BL/6J. Imagine a clinical study of longevity using 120 clones of you or me. Taurine may be effective at extending lifespan and healthspan of C57BL/6J mice but will it work as well using genetically diverse mice such as the UM-HET3 mice? Like humans, the UM-HET3 mice are genetically diverse (they segregate for about 11.5 million sequence va…

WHy does it have Taurine? I honestly don't know why any of the non-caffiene non-b vitamin ingredients are in "energy drinks" like Taurine.

I really wish they didn't have so much damn niacin(B3) in them. Niacin has side effects like sweating and flushing in doses not much higher than RDI, and yet one 500ml energy drink typically contains 250% RDI of niacin.

Like, why the fuck? At least cut it down to at most 100%.

Re: Taurine deficiency as a driver of aging

#266

Post by Jeff_Brown »

robocat wrote: post #248
diydsp wrote: post #241

Earlier quoted context omitted.

Ok. As im approaching my first half-kilo, my 250th can of energy drink, i'll slow down.

500g of taurine for a 100kg person - 50% chance you will be slowed down permanently (LD50 == Lethal Dose 50% - 1 in 2 chance of death).

One can of Red Bull feels like imminent death to me.

Re: Taurine deficiency as a driver of aging

#267

Post by phkahler »

jaggederest wrote: post #209
throwaway2037 wrote: post #198

Earlier quoted context omitted.

By the way: A 16 oz can of Monster contains 2 grams of taurine. My first thought when I reading your post (before I finished): How many grams of taurine per kilogram of body weight were used in the trial? I found: Taurine supplementation increases the life span of mice To determine whether the observed drop in taurine concentration contributes to aging, we orally administered control solution or taurine at 1000 mg pe…

Standard intake of taurine in most people is <200mg a day. That would be an astounding amount of taurine. Also, it's a little weird because humans can synthesize taurine, it's a major component of bile, so I'm unclear what mechanism could cause supplementation to have significant effects.

Just one possiblilty: Wikipedia says Taurine takes Cysteine as a precursor, so producing more taurine might reduce cysteine levels. Hypothetically perhaps some of the benefits of tuarine supplementation could actually be achieved by cysteine supplementation instead. Biology can be very complicated ;-)

Re: Taurine deficiency as a driver of aging

#268

Post by khimaros »

amarant wrote: post #264
spiderice wrote: post #207

Earlier quoted context omitted.

There is a comment much further down the page explaining how dosages don't translate across species like this. Apparently the human equivalent would be 6.48 grams per day.

Regardless of the humans body weight? I find that curious if so! Could you post a link to the comment you mentioned? I scrolled down but didn't find it... :(

probably this one:

> Human-mouse conversion ratio is 1:12.3

Re: Taurine deficiency as a driver of aging

#269

Post by RugnirViking »

winternewt wrote: post #218
AtlasBarfed wrote: post #202

Earlier quoted context omitted.

WHy does it have Taurine? I honestly don't know why any of the non-caffiene non-b vitamin ingredients are in "energy drinks" like Taurine.

According to GPT4 there's research indicating that taurine increases metabolism, improves athletic performance, helps regulate neurotransmitters (so could be construed to improve cognitive functioning), and improves cardiovascular health. I'd wager you can't conclude from any of that research that putting a gram of it in a drink will help with anything at all, but from a marketing perspective it's a name that carries…

according to gpt4 there's reasearch that indicates that spice melange assists in cognitive loads especially relating to navigation in fold space

Re: Taurine deficiency as a driver of aging

#270

Post by throwaway2037 »

vhcr wrote: post #203
throwaway2037 wrote: post #200

Earlier quoted context omitted.

You seem knowledgeable about sucralose ("Splenda" in US commercial branding). Thank you to share. On Wiki, it says that sucralose is "genotoxic", but provides no further information. I read the genotoxic Wiki page -- sounds terrible. What am I missing? To be clear: This is not a scare post, rather "explain it to me like I am a 5 year old"! When I Google >, most of the results are untrustworthy, click-bait news source…

The genotoxic edit was added by an IP editor citing an in-vitro study, I wouldn't pay much attention to it, you can find higher quality references on the article, for example this one: https://www.sciencedirect.com/science/article/pii/S027869151...

Nice post. Thanks for the info. I was bothered that "genotoxic" didn't have a reference.

For other readers, I didn't know what "in-vitro study" meant. Google tells me:

    In vitro is Latin for “in glass.” It describes medical procedures, tests, and experiments that researchers perform outside of a living organism. An in vitro study occurs in a controlled environment, such as a test tube or petri dish.
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