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Taurine deficiency as a driver of aging

science.org

101–110 of 301 posts

Re: Taurine deficiency as a driver of aging

#101

Earlier quoted context omitted.

Sucralose found in common sweetener damages DNA, may cause cancer [1] [1] https://www.medicalnewstoday.com/articles/sucralose-found-in...

Reality: At the very highest concentrations of the sucralose compound tested in this study, using cells in petri dishes, one marker of gene damage was slightly elevated

In reality, I try to minimize my exposure to known carcinogens.

This one is quite avoidable.

Re: Taurine deficiency as a driver of aging

#102
post #97

Earlier quoted context omitted.

So I take it you're on the "okay, they're not" side of that divide? I mean, how many more decades does one need to really make a decision on these?

There are studies for and against artificial sweeteners. There are studies funded by industry. There is such a thing as corruption in science and corruption in regulatory agencies. The global artificial sweetener market size is $7 Billion. https://www.healthline.com/health-news/this-common-sugar-sub...

I think you'll find nothing I said contradicts that statement.

Re: Taurine deficiency as a driver of aging

#103
I'm surprised to see no mention of exercise in the comment section. It seems that working out produces "[...] increased the concentrations of taurine metabolites in blood, which might partially underlie the antiaging effects of exercise."

For the able-bodied, it may be enough to incorporate more exercise into our life?

Re: Taurine deficiency as a driver of aging

#105
post #97

Earlier quoted context omitted.

There are studies for and against artificial sweeteners. There are studies funded by industry. There is such a thing as corruption in science and corruption in regulatory agencies. The global artificial sweetener market size is $7 Billion. https://www.healthline.com/health-news/this-common-sugar-sub...

I think you'll find nothing I said contradicts that statement.

You have a short memory. Not long ago you wrote the following

> I know I won't change anyone's already set opinions here, but for anyone reading this and not sure what is being discussed: there's absolutely nothing wrong with consuming sucralose.

Then I posted a link to a study showing Sucralose is toxic.

Re: Taurine deficiency as a driver of aging

#106
post #71

Earlier quoted context omitted.

MSM media is always trying to convince people they can live longer if they stick with coffee, berries, dark chocolate and wine — as if those foods needed boosters. And if true I’m quite sure we’d have people out there living to 150…

You probably can live longer if you stick with coffee (black), berries (minus the food you put the berries on top of), dark chocolate (unsweetened), and wine (in strict moderation).

The third most common cause of death in the United States, at least before COVID was a thing, is "accidental self-inflicted injury."

Heart Disease and Cancer, most in old age, are the top two.

Making micro adjustments to your diet just doesn't stand a chance at making a meaningful difference.

Re: Taurine deficiency as a driver of aging

#107

Obviously the real driver of aging is that there was no selective pressure to keep the organism working after sufficient semi-clones were brought online, and keeping an organism functional is a hard problem. The solution is to gain the ability to simulate the organism that results from a particular DNA sequence, understand the design problems in the organism, fix the problems, then alter human DNA to include the fixe…

There are almost certainly easier solutions that at least mitigate the problem even if it doesn't fully solve the problem. A similar problem might be type 1 diabetes, where an issie with the immune system causes the body attacks the cells which produce insulin. There is no cure for type 1 diabetes. However, now that we understand some of the mechanisms, we can monitor blood sugar levels and artificially regulate them so what was previously a fatal disease is now manageable. If we can figure out similar mechanisms with aging, we can treat it even if we can't completely "cure" it.

Re: Taurine deficiency as a driver of aging

#108

Earlier quoted context omitted.

For what it’s worth, Wikipedia is currently referencing a 2009 study which had previously tested 1000mg/kg in humans.

Really? For a 100kg human (me) that is 100g a day of taurine which is more than 3 ounces or this whole bottle https://www.amazon.com/NOW-Supplements-Taurine-Strength-Caps... and costs about $9. Seems like a lot. Contrast that to the claim that people should eat about 800mg/kg a day of protein overall https://www.sclhealth.org/blog/2019/07/how-much-protein-is-s...

Not saying it is a good idea, but based on that one study I did not read, the amount is tolerable without acute symptoms.

Re: Taurine deficiency as a driver of aging

#109
post #105

Earlier quoted context omitted.

I think you'll find nothing I said contradicts that statement.

You have a short memory. Not long ago you wrote the following > I know I won't change anyone's already set opinions here, but for anyone reading this and not sure what is being discussed: there's absolutely nothing wrong with consuming sucralose. Then I posted a link to a study showing Sucralose is toxic.

Yes and I'll stand by that statement. I think you'll find, once again, that nothing I said contradicts the statement you made, which is:

> There are studies for and against artificial sweeteners. There are studies funded by industry. There is such a thing as corruption in science and corruption in regulatory agencies. The global artificial sweetener market size is $7 Billion.

I get that you're on the "okay, they're not" side of that divide that we all find themselves on. That's fine, and you are welcome to come to that conclusion. It's not one I've come to, but that's why the world is made up of different people. Remember, what I actually said was:

> These artificial sweeteners are among the most studied chemicals in the world. At some point you've gotta say okay, they're fine, or okay, they're not.

as well as the post you quoted. So I'm really not sure what you're arguing about here. Nothing I said contradicts your statement of "There are studies for and against...". Indeed, there are. Decades of them.

Re: Taurine deficiency as a driver of aging

#110

...in mice.

If you RTFA you will note it specifically calls out the multiple models tested. It also points out that these are evolutionarily conserved pathways, so of course the translatability chances are higher than baseline. To top it off, some of those pathways have already been associated with increased healthspan and lifespan in many other studies.

I am interested in informed skepticism, because this is kinda compelling.

Disclaimer: I don't really know shit.

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