As a radiology software developer: please please let JPEG XL become a thing. I sincerely hope this might make Chrome change its mind. JPEG XL is a game changer for 16 bit lossless images. The technical landscape for these kinds of images today is barren.
Does it really matter? These days decoding image with JS or Wasm should be fine. It's not video.
A mammogram on the other hand, might be 300 images of lossless 4k resolution, which could clock in at about 2 gigabytes. That could be per breast in a given study, and a study could have prior mammograms attached as well.
You will hit memory limits, so you need to be able to unload and load data intelligently and quickly.