SRI’s radioactive contamination treatment is now in its first-in-human trial
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Re: SRI’s radioactive contamination treatment is now in its first-in-human trial
#2RadAway
Re: SRI’s radioactive contamination treatment is now in its first-in-human trial
#3This is cool. This is for removing nucleotides from the body, rather than repairing damage done by radiation exposure (which probably can’t be done with drugs).
Re: SRI’s radioactive contamination treatment is now in its first-in-human trial
#4Kind of devoid of any details, what radionuclides does it actually work on? Same set as DTPA?
And how do you trial this? Contaminating subjects with plutonium would seemingly violate ethics guidelines.
Re: SRI’s radioactive contamination treatment is now in its first-in-human trial
#5Kind of devoid of any details, what radionuclides does it actually work on? Same set as DTPA? And how do you trial this? Contaminating subjects with plutonium would seemingly violate ethics guidelines.
They're determining safety and tolerability, not efficacy. For this, they just need adequately compensated trial volunteers who take one of several different doses of the medicine and track/report symptoms, have some doctor visits, and get a lot of blood drawn. Oh, and for this one, sample urine and feces. You can read the clinical trial doc: https://clinicaltrials.gov/ct2/show/NCT05628961
Re: SRI’s radioactive contamination treatment is now in its first-in-human trial
#6Kind of devoid of any details, what radionuclides does it actually work on? Same set as DTPA? And how do you trial this? Contaminating subjects with plutonium would seemingly violate ethics guidelines.
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Re: SRI’s radioactive contamination treatment is now in its first-in-human trial
#7> the previously approved transuranic radionuclide decontamination drug, diethylenetriamine pentaacetate (DTPA), can only be administered intravenously or by nebulizer—both of which are less feasible options for rapidly treating large populations than the oral route of HOPO 14-1.
Man, the hypothetical scenarios they used to get funding for this must have been horrific.
Let's hope this drug is never needed.
Re: SRI’s radioactive contamination treatment is now in its first-in-human trial
#8This is cool. This is for removing nucleotides from the body, rather than repairing damage done by radiation exposure (which probably can’t be done with drugs).
This is factually incorrect. This HOPO 14-1 chelates f-block elements, many of which are radioactive, without depleting other metal ions from the body which are essential for metabolism and other functions. Also, there are a large number of agents which can mitigate the damage done by radiation exposure when administered prophylactically
Re: SRI’s radioactive contamination treatment is now in its first-in-human trial
#9Kind of devoid of any details, what radionuclides does it actually work on? Same set as DTPA? And how do you trial this? Contaminating subjects with plutonium would seemingly violate ethics guidelines.
They're determining safety and tolerability, not efficacy. For this, they just need adequately compensated trial volunteers who take one of several different doses of the medicine and track/report symptoms, have some doctor visits, and get a lot of blood drawn. Oh, and for this one, sample urine and feces. You can read the clinical trial doc: https://clinicaltrials.gov/ct2/show/NCT05628961
To get full approval they could combine this with animal efficacy studies like they did for the smallpox treatment tecoviromat, since you can’t give smallpox to trial participants either. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6663070/
It turned out to be really useful to have tecoviromat for the recent mpox outbreak
Re: SRI’s radioactive contamination treatment is now in its first-in-human trial
#10> the previously approved transuranic radionuclide decontamination drug, diethylenetriamine pentaacetate (DTPA), can only be administered intravenously or by nebulizer—both of which are less feasible options for rapidly treating large populations than the oral route of HOPO 14-1. Man, the hypothetical scenarios they used to get funding for this must have been horrific. Let's hope this drug is never needed.
And if it is ever needed, let's hope the stockpiles and logistics are in place to allow for quick distribution of the drug to broad portions of populations which are affected. We saw with COVID-19 that the U.S. let the Strategic National Stockpile become depleted. In the worst case, let's hope the drug has been maintained to be immediately available.