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Ozempic drug supresses desire to smoke, drink and more?

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Re: Ozempic drug supresses desire to smoke, drink and more?

#491

Post by LazyMans »

rjbwork wrote: post #313
LazyMans wrote: post #155

Yes. On a compounded semaglutide. I can finally control my hunger and a nice unexpected effect has been losing a desire to drink large quantities of alcohol. I don’t drink during the week anyway, but it seems to be the volume that turns me off to drinking. Thus a few cocktails are all I can tolerate. For context, Im 30, male, would be defined as a binge drinker on weekends. Oh, and I’ve given up nicotine entirely. I…

Can you share this "compounded semaglutide" source? My doctor mentioned it but I'm a bit anxious about it. Everything out there seems so sketchy.

HenryMeds. It’s a US pharmacy. I wouldn’t be afraid, it’s no different than picking up generic medications from your local pharmacy.

Re: Ozempic drug supresses desire to smoke, drink and more?

#492

Post by joedevon »

reaperman wrote: post #461
joedevon wrote: post #460

Earlier quoted context omitted.

I believe you. Look, I read a bunch of contradictory stuff on the internet about this and am close to a good number of people in healthcare who told me compound pharmacies are legit and that there's a lot of FUD on the internet. But I'm not pretending to be an expert in law or medicine. People need to research this and do what they feel comfortable with. That said, I'd personally prefer if the prices came down, the s…

To your point, there is a ton of gray area. One site I can responsibly link here is https://www.peptidesciences.com/ -- they're very careful about working to stay on the right side of the law, and they sell semaglutide and tirzepatide for ostensibly "not-for-human-consumption" (and at very, very high prices). So the raw ingredient, in non-medical settings, is not inherently impossible to import and sell legally. But…

I'm gonna end the conversation here and let you have the last word, because I don't even feel comfortable talking about compounding pharmas.

From what I've read, sites like the above are really dangerous, because people are ordering from them and like you said, are NOT for human consumption.

Compound pharmacies, from what I understand, are meant for human consumption. From the healthcare people I know personally, including my own doctor, they have been used for ages and are totally legit. But folks should just talk to their doctor before taking anything.

Re: Ozempic drug supresses desire to smoke, drink and more?

#493

Post by fatnoah »

imtringued wrote: post #367
ramraj07 wrote: post #196

Earlier quoted context omitted.

For a long time we have known the existence of a network of hormones controlling our apetite on the gut brain axis, with names like ghrelin, leptin, glp-1, orexin, somatostatin, list goes on [1]. Issue was the network was tres complicé and hard to perturb without getting the opposite effect than what we wanted. Finally with glp-1, sglt2 and pcsk9 inhibition we are starting to be able to correct in the right way. To a…

People talk about willpower but they ignore social influences like children learning habits from their parents or simply being forced by their parents to become obese (all it takes is a portion size that is slightly too big and demanding that you eat the full plate). No amount of willpower is going to end that unless you want to blame children for not running away from home.

> People talk about willpower but they ignore social influences like children learning habits from their parents or simply being forced by their parents to become obese

As a very young child, my family was probably on the upper end of poor. "Treats" were rare and food was not anything to be wasted at all. I'm almost 50 now, and it's virtually impossible for me to throw away food. I have to have an inner monologue conversation with myself about whether I really need to finish my portion and whether it's OK to discard it. Needless to say, despite being very physically active, my weight has challenged me my entire life.

As a parent, I'm irrationally proud of my child for being able to stop eating when they're full, even if it's ice cream or a treat. That's actually helped me get over throwing food away (a little bit, at least)

Re: Ozempic drug supresses desire to smoke, drink and more?

#494

Post by uslic001 »

36933 wrote: post #395
CapstanRoller wrote: post #312

Earlier quoted context omitted.

>I feel great and my brain seems to be functioning as well as when I was in my 20’s >but my untreated ADHD seems to be getting worse. I had very similar results after taking ketamine for treatment-resistant depression. It eliminated all my compulsive tendencies for getting cheap dopamine hits (food, doomscrolling, etc), reset my tolerance to everything (caffeine, ADHD meds, alcohol), and made my ADHD worse while impr…

Ketamine treatments help people, because ketamine is a dissociative drug. It makes you not feel your suffering, also makes you not feel the positive feelings. That’s why you’re not eg doomscrolling. It doesn’t feel good for you anymore. If you’re not getting treatments regularly, you will be back to suffering in a few months likely. In my opinion, there are better alternatives and more effective treatments than livin…

Ketamine is no better than placebo for depression: https://www.science.org/content/article/ketamine-no-better-p...

Re: Ozempic drug supresses desire to smoke, drink and more?

#495

Post by smileysteve »

prepend wrote: post #397
0zemp2c wrote: post #177

Earlier quoted context omitted.

How dangerous is it to have a new $1k/month bill you need to pay forever? So far there is no indication insurance companies are going to pay for 100 million Americans going on Ozempic who aren't diabetic... Anecdotally, another danger is people confusing less eating with a healthy diet. I know someone on Ozempic...eats less but what is eaten is the same old junk...

> So far there is no indication insurance companies are going to pay for 100 million Americans going on Ozempic who aren't diabetic... What’s the cost/benefit of weight loss and diabetes control vs $12k/year? I would expect people with high obesity are very expensive to insure and insurance can’t drop people any more. It may be cheaper to pay for ozempic (especially at whatever negotiated rate insurance pays) than to…

Most of the data is showing that Ozempic is not required long term though so a single year might be all that's required; and for the morbidly obese;

$12k is going to be less than the typical admission to a hospital (for injury, illness, heart disease, diabetes related incident.)

Re: Ozempic drug supresses desire to smoke, drink and more?

#496

Post by smileysteve »

Ginden wrote: post #376
mym1990 wrote: post #68

Earlier quoted context omitted.

I am not holding Ozempic to needing to be the cure for anything. My point is that people without diabetes are looking to this drug for weight loss, at which point they create a dangerous dependency, with no hard evidence that their actual health improves. This is opposed to coming up with long term solutions that involve re-evaluating daily decisions that lead to some of these diseases in the first place. If Ozempic…

> This is opposed to coming up with long term solutions that involve re-evaluating daily decisions that lead to some of these diseases in the first place. Medicine tried this. It's extremely hard to actually to do it in practice. Obviously, it's better solution, but we are living in real world, where we have to choose "good enough" solutions over those deemed "better, but infeasible for 90% of patients".

"re-evaluating daily decisions" is exactly what suppressing these hormones allow people to do; so that they can make rational instead of hormone driven decisions.

Re: Ozempic drug supresses desire to smoke, drink and more?

#497

Post by bevesce- »

nebulousthree wrote: post #465
yieldcrv wrote: post #425

Earlier quoted context omitted.

> Find the right exercise/workout for you and it'll be its own reward. appreciate the perspective but I want to be like the people that feel pulled to "find" it at all.

The pleasure of working out only becomes obvious after you've built the habit to do so. You'll know you've built the habit when it starts to feel bad when you don't work out on a day you're normally supposed to. It's pretty similar to a drug addiction.

I've been doing calisthenics 3 times a week since 2019. When I skip a day I feel enormous amount of guilt and I can't sleep when the night comes. Still, I don't like every moment of doing the exercises and I have a feeling of time being wasted by tending to my body instead of doing something with my family, cooking for them or being creative. What's more doing the workout eats a huge amount of my will power and leaves me unwilling to do any other chore for that day.

Re: Ozempic drug supresses desire to smoke, drink and more?

#498

Post by CapstanRoller »

uslic001 wrote: post #494
36933 wrote: post #395

Earlier quoted context omitted.

Ketamine treatments help people, because ketamine is a dissociative drug. It makes you not feel your suffering, also makes you not feel the positive feelings. That’s why you’re not eg doomscrolling. It doesn’t feel good for you anymore. If you’re not getting treatments regularly, you will be back to suffering in a few months likely. In my opinion, there are better alternatives and more effective treatments than livin…

Ketamine is no better than placebo for depression: https://www.science.org/content/article/ketamine-no-better-p...

This is not peer reviewed, looked at only 40 people, and has dubious methodology.

Re: Ozempic drug supresses desire to smoke, drink and more?

#499

Post by shadowpho »

pton_xd wrote: post #383
shadowpho wrote: post #283

Earlier quoted context omitted.

>Exercise is free and the side effects are you get stronger, more energetic, and better looking. And that works for what, 3% of the people that try it?

> And that works for what, 3% of the people that try it? Exercise is medicine! Far too few people understand that unfortunately. Something is wrong with our culture when the majority have the attitude that exercise isn't worth doing.

> Something is wrong with our culture

And every other culture on earth? You might as well "humanity", except it's a fairly new phenomena, so "humanity in last 100 years"

Re: Ozempic drug supresses desire to smoke, drink and more?

#500

Post by Auracle »

cromulent wrote: post #327
Auracle wrote: post #223

Earlier quoted context omitted.

I don’t know if I want a drug to exist that allows people to be gluttons without consequence. It’s like a modern (and real) vomitorium.

Some people will tell you though that they can eat anything and not put on weight - this is simply allowing others to do the same, right. A vomitorium is simply the large exit pathway in stadia for rapid egress of many people. The idea that ancient Romans had facilities dedicated to vomiting has been debunked.

That's why I said (real), I know they didn't exist - though I'm guessing somewhere, sometime in history it has.

Those people that tell you they can eat anything and not put on weight have a very different idea of what "anything" is than fat people, with probably an actual exception here and there (along with teenagers).

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