Ketamine no better than placebo at alleviating depression, unusual trial finds
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Re: Ketamine no better than placebo at alleviating depression, unusual trial finds
#2> In a new study that is yet to be peer reviewed
Thank you very, very much to the author for saying this
Re: Ketamine no better than placebo at alleviating depression, unusual trial finds
#3> They gave volunteers ketamine while they were under general anesthesia, theoretically preventing the participants from going on a trip.
Maybe it's the trip that helps.
Re: Ketamine no better than placebo at alleviating depression, unusual trial finds
#4> They gave volunteers ketamine while they were under general anesthesia, theoretically preventing the participants from going on a trip. Maybe it's the trip that helps.
Not to mention other possible effects of being in general anesthesia (aside from the lack of consciousness) that prevent the effectiveness.
Re: Ketamine no better than placebo at alleviating depression, unusual trial finds
#5> In a new study that is yet to be peer reviewed Thank you very, very much to the author for saying this
Even if it was peer reviewed, most published studies are non-replicated/bad methodology BS.
So "yet to be peer reviewed" means the study paper is closer to "random generated garbage text" than to "important insight".
Re: Ketamine no better than placebo at alleviating depression, unusual trial finds
#6Then it's still no worse than widely used SSRI's, which also mostly don't differ from placebo
Re: Ketamine no better than placebo at alleviating depression, unusual trial finds
#7Then it's still no worse than widely used SSRI's, which also mostly don't differ from placebo
Don't post lies and FUD here please.
Re: Ketamine no better than placebo at alleviating depression, unusual trial finds
#8> They gave volunteers ketamine while they were under general anesthesia, theoretically preventing the participants from going on a trip. Maybe it's the trip that helps.
I see so many studies trying to somehow distill trippy drugs into an isolated, side-effect free, take a pill and get back to work treatment. Maybe there's something to be found there, would be huge, but my hope is that we don't waste all the will and funding down this path without more fully exploring the path where we admit that yes, the trip helps, and we'll just need to deal with the lack of blinding.
Re: Ketamine no better than placebo at alleviating depression, unusual trial finds
#9Then it's still no worse than widely used SSRI's, which also mostly don't differ from placebo
I don't think SSRIs "mostly don't differ from placebo".
SSRIs only seem to work while you take them.
Some report side-effects that make them not worth it.
Others report that they're life-changing.
The case for Ketamine is that some periodic (but not permanent) use would bring you out of depression, rather than put it in check by indefinite drug use. As far as I understand, this is what's being challenged.
Re: Ketamine no better than placebo at alleviating depression, unusual trial finds
#10> They gave volunteers ketamine while they were under general anesthesia, theoretically preventing the participants from going on a trip. Maybe it's the trip that helps.
I see so many studies trying to somehow distill trippy drugs into an isolated, side-effect free, take a pill and get back to work treatment. Maybe there's something to be found there, would be huge, but my hope is that we don't waste all the will and funding down this path without more fully exploring the path where we admit that yes, the trip helps, and we'll just need to deal with the lack of blinding.
Literally the last line of the article:
"Future studies of novel antidepressants with acute psychoactive effects should make stronger efforts to mask treatment assignment to minimize the effects of subject-expectancy bias."
Instead of pondering if their method is at fault for their negative result, the conclusion is to double down and working even harder at masking the effects.