Live data from Hacker News

Ozempic drug supresses desire to smoke, drink and more?

theatlantic.com

481–490 of 504 posts

Re: Ozempic drug supresses desire to smoke, drink and more?

#481

Earlier quoted context omitted.

That sounds like the lesser of two evils to me. Get healthier now and maybe sometime later lose access to the thing that helps you be healthier...or don't get healthier now? Yeah, there are other, orthogonal, choices but I don't think they're part of this particular decision matrix.

Yep. I lost 30lbs on it in 3 months. It took me 10 years to gain that weight. So I guess if it takes me 10 more years to gain it back I can look into taking it again.

People usually gain back that weight much quicker. All it could take is one bad month and you could gain it all back.

Re: Ozempic drug supresses desire to smoke, drink and more?

#482

Earlier quoted context omitted.

Yep. I lost 30lbs on it in 3 months. It took me 10 years to gain that weight. So I guess if it takes me 10 more years to gain it back I can look into taking it again.

People usually gain back that weight much quicker. All it could take is one bad month and you could gain it all back.

Totally impossible. I’d have to be eating like way more than I ever have to do that.

I went off for three months and kept losing weight throughout.

And the data from these drugs shows they gain it back at regular rate at most.

Re: Ozempic drug supresses desire to smoke, drink and more?

#483

Earlier quoted context omitted.

You can get these wholesale from China from "reputable" gray-market wholesalers who get the chemicals made at contract manufacturing facilities. BYO QA/QC though, as with all non-FDA drugs. That's the huge catch, and it sucks for consumers. Testing just for active ingredient is >$100 and takes about a month. Testing for proper buffering agents, harmful contaminants, microbial contamination, etc is essentially unavail…

where is this grey market? apparently it's not as simple as just searching aliexpress :)

Alibaba is more likely to have b2b products

Re: Ozempic drug supresses desire to smoke, drink and more?

#484
post #456

Earlier quoted context omitted.

How so? We don't know of any cure for depression, but with ketamine we have an effective rapid treatment. Ketamine has a great therapeutic range, a well-understood side effect profile, and can bring a patient back from the brink of suicide in a matter of hours. It's also incredibly inexpensive to produce, on par with aspirin. Why shouldn't we use it?

That’s the thing. We don’t know a cure, but we know of people who were cured. We just don’t really know how or why, scientifically speaking. And as far as I know there was never someone getting cured from t1 diabetes. That’s what I meant by apples and oranges. Ketamine or suffering & death? Ketamine no question. I agree, but it’s not so black and white how you may perceive it. It might be ketamine or death for you, I…

Ketamine saved my life, but I also know people who say MDMA saved their life (and I believe it).

In my case, MDMA would not have been the appropriate treatment.

All of the things we are discussing have value and a role in mental health care. It doesn't have to be a contest.

Re: Ozempic drug supresses desire to smoke, drink and more?

#485

Earlier quoted context omitted.

>I only tried combining them and nearly went to the ER Could you elaborate on that? I'm currently still a smoker (working on it...) and on Concerta. Your note alarms me :)

Not the person you're replying to, but what helped me quit was the book "How to stop smoking" by Alan Carr. Highly recommend working through it and taking his point about cold turkey in good faith. Good luck!

I have a fun experience with the Alan Carr book. The first time I read it, I was laughing the whole way through thinking about how much it was written like straight-up brainwashing propaganda, but I had committed to a friend to reading it all the way through. I got to the end where the final bit is something like "now just say out loud 'I am a non-smoker and when I wake up tomorrow I will never have a cigarette again'". I chuckled, thought it was ridiculous, and the next morning I woke up and didn't have a smoke. That lasted about 2 years until I got extremely drunk one night after a rough breakup, had smoked the whole night, and was pretty much instantly hooked again.

Ten years later I went through the exercise again, but sadly it didn't work nearly as well as it had the first time around.

Re: Ozempic drug supresses desire to smoke, drink and more?

#486
post #103

Earlier quoted context omitted.

Steroid users do it all the time and I haven’t heard of steroid users dealing with infections much.

I'm sure its because most people aren't going to talk about illegal drug use and when it goes wrong.

There are tons of online places where people openly discuss steroid use like r/steroids and many oldschool phpbb-style steroid forums

Re: Ozempic drug supresses desire to smoke, drink and more?

#487

Earlier quoted context omitted.

Oh my, is retinal detachment a known potential side effect of the drug? Or is that a complication of diabetic retinopathy or some other condition that you already had? This sounds frightening. Hope they were able to reattach it, and hope you're doing alright.

I can’t find the specific study this website cites, but it mentions: > In a 2-year trial among patients with type 2 diabetes and high cardiovascular risk, patients treated with this drug experienced a great incidence of diabetic retinopathy complications (3% vs 1.8%). The absolute risk was greater in patients with a history of diabetic retinopathy at baseline (8.2%[drug] vs 5.2%[placebo]) than those without (0.7%[dru…

This was covered in a recent YouTube video I saw on semaglutide treatment. The real problem is rapid changes in your blood glucose levels can radically change your eyesight, regardless of the cause. So, with Semaglutide and other drugs, you need to have a slow ramp-up period and let your body get adjusted to the drug, otherwise you risk having those rapid changes to your blood glucose levels.

Re: Ozempic drug supresses desire to smoke, drink and more?

#488
post #457

Earlier quoted context omitted.

> Ketamine didn’t heal me, my perspective just changed I thought that was the entire point of the treatment. Is that not the case?

I don’t know it might be. I went in with the mindset of wanting it to help me end my suffering, not change my perspective. I think that’s the case for most people.

Your perspective is the suffering though, unless I am missing something? The whole thing with trauma response and all the various things that come from that is that different things have different effects on different people, because their perspectives are different. The treatments that work (CBT, EMDR, etc) also rely on changing your perspective of the event or your response to it.

Re: Ozempic drug supresses desire to smoke, drink and more?

#489

Earlier quoted context omitted.

Yep. I lost 30lbs on it in 3 months. It took me 10 years to gain that weight. So I guess if it takes me 10 more years to gain it back I can look into taking it again.

People usually gain back that weight much quicker. All it could take is one bad month and you could gain it all back.

An average person would have to eat 5500 kcal per day to gain this much weight in a month. It's probably not impossible, but I would say it is very unlikely.

Re: Ozempic drug supresses desire to smoke, drink and more?

#490

Earlier quoted context omitted.

I like caffeine, unfortunately even small amounts tend to make me irritable and sick at the end of the day. Wasn’t always like that

What changed and when?

I’m not sure what, but a few years ago caffeine started to give me anxiety sometimes, or sick. I guess I just got older.
Post reply on HN