I’ve been on Mounjaro since August. Down almost 60lbs, and it’s been a life changer. Have I had some gastrointestinal issues, sure, but expected. I feel great and my brain seems to be functioning as well as when I was in my 20’s. Now, when I go to the bar with friends, I end up having maybe 2 beers and although enjoyable, I don’t feel that light switch turning on which encourages me to drink more. Can I force myself…
Ozempic drug supresses desire to smoke, drink and more?
431–440 of 504 posts
Re: Ozempic drug supresses desire to smoke, drink and more?
#432Earlier quoted context omitted.
For a long time we have known the existence of a network of hormones controlling our apetite on the gut brain axis, with names like ghrelin, leptin, glp-1, orexin, somatostatin, list goes on [1]. Issue was the network was tres complicé and hard to perturb without getting the opposite effect than what we wanted. Finally with glp-1, sglt2 and pcsk9 inhibition we are starting to be able to correct in the right way. To a…
can we do this for working out and exercise? I’m lean but dont do that and can recognize the benefits. It would be cool if we could pharmacologically make that appealing too. What if we could just continually swap in states. Executive work mode, ah it feels so good to think and focus. Empath mode, ah it feels so good to build relationships. Brolic mode, ah it feels so good to think about working out, and actually wor…
Re: Ozempic drug supresses desire to smoke, drink and more?
#433Earlier quoted context omitted.
>I feel great and my brain seems to be functioning as well as when I was in my 20’s >but my untreated ADHD seems to be getting worse. I had very similar results after taking ketamine for treatment-resistant depression. It eliminated all my compulsive tendencies for getting cheap dopamine hits (food, doomscrolling, etc), reset my tolerance to everything (caffeine, ADHD meds, alcohol), and made my ADHD worse while impr…
Ketamine treatments help people, because ketamine is a dissociative drug. It makes you not feel your suffering, also makes you not feel the positive feelings. That’s why you’re not eg doomscrolling. It doesn’t feel good for you anymore. If you’re not getting treatments regularly, you will be back to suffering in a few months likely. In my opinion, there are better alternatives and more effective treatments than livin…
If anything, the after-effects of ketamine treatment alleviate my lifelong dissociation and other symptoms depression and PTSD. Something about the induced dissociation "wraps around" and snaps people back into fully being present.
Have you ever had ketamine treatment? Where are you getting these conclusions?
Re: Ozempic drug supresses desire to smoke, drink and more?
#434Earlier quoted context omitted.
this is not true at all. the dissociative effects only last a few hours. the clinical benefit is because ketamine stimulates neurogenesis in the mPFC and hippocampus, restoring plasticity lost in depressed patients. don't make unsubstantiated leaps :-)
Yes the immediate effects last for a few hours. I didn’t say otherwise. The current scientific literature paints a mixed picture of ketamine. While it can stimulate neurogenesis, there is a definite potential for neurotoxicity. Not to mention that there are no long term studies out there. There are countless people reporting being anhedonic after treatments. Only a few people have been reported to not relapse before…
So what? Ketamine is a treatment, not a cure.
Would you apply the same logic to insulin for T1 diabetes?
Re: Ozempic drug supresses desire to smoke, drink and more?
#435Earlier quoted context omitted.
Ketamine treatments help people, because ketamine is a dissociative drug. It makes you not feel your suffering, also makes you not feel the positive feelings. That’s why you’re not eg doomscrolling. It doesn’t feel good for you anymore. If you’re not getting treatments regularly, you will be back to suffering in a few months likely. In my opinion, there are better alternatives and more effective treatments than livin…
This isn't true. I am not dissociated when not actively undergoing the treatment. If anything, the after-effects of ketamine treatment alleviate my lifelong dissociation and other symptoms depression and PTSD. Something about the induced dissociation "wraps around" and snaps people back into fully being present. Have you ever had ketamine treatment? Where are you getting these conclusions?
Ketamine didn’t heal me, my perspective just changed, which can be valuable though.
Re: Ozempic drug supresses desire to smoke, drink and more?
#436A drug that promotes weight loss, lessens the desire to smoke, drink, etc...sounds too good to be true? From what I have heard, all of these issues come back as soon as someone comes off the drug. So either a person is committing to a lifetime of being dependent on this drug, or a person is committing to some period of time of ideal living, followed by a possible time of depression after reverting to the status quo.
Re: Ozempic drug supresses desire to smoke, drink and more?
#437Earlier quoted context omitted.
Yes the immediate effects last for a few hours. I didn’t say otherwise. The current scientific literature paints a mixed picture of ketamine. While it can stimulate neurogenesis, there is a definite potential for neurotoxicity. Not to mention that there are no long term studies out there. There are countless people reporting being anhedonic after treatments. Only a few people have been reported to not relapse before…
>Only a few people have been reported to not relapse before 24 weeks. So what? Ketamine is a treatment, not a cure. Would you apply the same logic to insulin for T1 diabetes?
Re: Ozempic drug supresses desire to smoke, drink and more?
#438Earlier quoted context omitted.
>not solely controllable by willpower so, would you say a solution to the problem that lets you eat as much as you want, so you don't have to use your willpower, be an appropriate solution to suggest? There is a difference between taking last-resort medication for the rest of your life, and eating apples.
People like you are the absolute worst to deal with when struggling to lose weight. I managed to lose 150lbs, and it had very little to do with will power, at least the way people like you mean it. I had to reconfigure my entire life around it. I kept barely enough food in the house to meet my calorie target for the week. I once fell asleep while driving home from work and ran off the road because my blood sugar was…
It is people like you who are the absolute worst to deal with. You take a specific example which probably does not not apply to your body, completely and completely twisted what was said so you can both be a victim and feel superior.
I specifically stated a diet that for a person who is working out a couple of hours per week, there is a way to constantly eat and minimize the caloric intake despite large amounts of food. I did not remotely suggest stuffing your face all day is a willpower-based solution to a thyroid problem.
I'm 5'11. In my early 30s, I was a 31 waist, 170lb, benched a full set of 400lb, ran cross country, and had 6% body fat. In my late 30s, I was a 34 waist with high blood pressure. I made the change in my diet, and a few years later, I'm a 31 waist, 170lb, normal blood pressure, and 10% bodyfat, and I eat as much as I feel like, just not whatever I feel like.
This is a solution for maintaining a healthy weight in an active lifestyle, that uses zero willpower, because my willpower is bad. This is not a solution for someone with a thyroid problem who needs to lose almost the weight of my whole body.
I don't know what it is with you and this other guy. You read very simple basic text, and you reply to something you've completely made up. It's like your brain paints a virtual world for yourself where you can feel constantly offended. No one's out to get you. No one's making fun of you. People are talking about something that clearly wasn't for you, so you inject yourself into the conversation so you can feel attacked. Stop that.
Re: Ozempic drug supresses desire to smoke, drink and more?
#439Earlier quoted context omitted.
Find the right exercise/workout for you and it'll be its own reward. Shouldn't take more than a bit of caffeine to get you moving at that point. As to empath mode, you've just described MDMA. But it'd be nice if there were something a little less intense. That you could take weekly without frying your brain & was mild enough for family/work social situations. (And no, alcohol doesn't fit the bill).
> Find the right exercise/workout for you and it'll be its own reward. appreciate the perspective but I want to be like the people that feel pulled to "find" it at all.
The high can be way better than you'd believe possible before you try. Or if you don't believe personal anecdote.. /something/ must be keeping all those people coming back to it at considerable expense, hassle and time.
Re: Ozempic drug supresses desire to smoke, drink and more?
#440Earlier quoted context omitted.
and... this person now takes these last-measure pills forever? or here in the real world, do they use the pills to lose weight, and then maintain that normal weight forever with... perhaps a diet trick that works? people who have to take last-measure medication usually don't stop eating when they are full. i know, it's weird to tell someone who doesn't stop eating when they're full, how to still maintain weight if th…
I’m hopeful that it’s more like 3 months out of the year. Looking back over the years, I’ve gained roughly 5lbs/year since I hit 30. Now in my late 40’s, during Covid, it seems like that went to 10lbs/year. The first 3 months on mounjaro, I lost 20lbs, so that cycle should be sufficient. I’d stay on it permanently, if it weren’t for the $1200/month.
I tried this a few years before going with my "apple diet." It works, but my bloodwork after a few years said I need to stop. There is a catch. The first year, you Cannot pass gas. That clumped oil that comes out, comes out very easily, and unfortunately Alli makes you gassy too. This side-effect goes away in about a year if you power through it.
Not a dietician or a doctor, but perhaps your mounjaro treatment can be cycled with Alli (cheap, OTC) every few years to save some cash. Invest in a large bottle of Dawn dishsoap. Put it in a spray bottle and spray the bowl after you do your stuff. You'll have to, just trust me.