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Ozempic drug supresses desire to smoke, drink and more?

theatlantic.com

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Re: Ozempic drug supresses desire to smoke, drink and more?

#421

Post by ennasila »

MandieD wrote: post #57
lumb63 wrote: post #23

I’m glad people are enjoying Ozempic. My experience from seeing a family member on it, is I would not touch it if I were a 500-pound alcoholic smoking two packs of cigarettes a day. That’s an exaggeration since it probably outweighs the health issues there, but only slightly. The person I know taking Ozempic has only lost weight (35 lbs) due to the fact that eating now makes her sick. She has been sapped of all energ…

Your relative’s sad story reminds me of a short story I read a few years ago about a miracle pill that leaves about 90% of its takers perfectly slim and able to stay that way eating anything, after a few truly disgusting initial days of elimination, but kills the other 10% gruesomely. Because it’s so wonderfully effective for the majority, there ends up being a ton of social and economic pressure for anyone even slig…

Great story. There were parts that made me think the pill was a metaphor for the covid vaccine, but this story was written several months before the vaccine was released

Re: Ozempic drug supresses desire to smoke, drink and more?

#422

Post by Scoundreller »

reaperman wrote: post #175
scheme271 wrote: post #21

Earlier quoted context omitted.

GLP-1 agonists are a bit more tricky since they are temperature sensitive and need to be injected. You'll really need to be careful to keep it sterile and handle it properly. Whether the "research chemical" will receive the proper care until it gets into your hands is something that you're literally gambling your health on.

You ship it as a dry/lypohilized powder, both semaglutide and tirzepatide survives long China->Europe shipping in the summer just fine, with customs delays. The testing I've seen showed 99.965% purity of semaglutide after 22 days in shipping from China to Poland during April. Tirzepatide shows 99.064% purity after 58 days of shipping in October-November. These didn't start out at 100.00% purity either, so they likely…

> That size filtration will filter out any lifeforms (fungal, bacterial, viral) while allowing the peptide/drug itself to pass through

0.22 won't filter out viruses, but time will inactivate enveloped viruses (which are usually the ones you want to avoid injecting), and source control/proper handling should take care of the rest.

Re: Ozempic drug supresses desire to smoke, drink and more?

#423

Post by valec »

36933 wrote: post #395
CapstanRoller wrote: post #312

Earlier quoted context omitted.

>I feel great and my brain seems to be functioning as well as when I was in my 20’s >but my untreated ADHD seems to be getting worse. I had very similar results after taking ketamine for treatment-resistant depression. It eliminated all my compulsive tendencies for getting cheap dopamine hits (food, doomscrolling, etc), reset my tolerance to everything (caffeine, ADHD meds, alcohol), and made my ADHD worse while impr…

Ketamine treatments help people, because ketamine is a dissociative drug. It makes you not feel your suffering, also makes you not feel the positive feelings. That’s why you’re not eg doomscrolling. It doesn’t feel good for you anymore. If you’re not getting treatments regularly, you will be back to suffering in a few months likely. In my opinion, there are better alternatives and more effective treatments than livin…

this is not true at all. the dissociative effects only last a few hours. the clinical benefit is because ketamine stimulates neurogenesis in the mPFC and hippocampus, restoring plasticity lost in depressed patients.

don't make unsubstantiated leaps :-)

Re: Ozempic drug supresses desire to smoke, drink and more?

#424

Post by joedevon »

jshaqaw wrote: post #400

It’s interesting to me how much of the hostility to this drug has a moral dimension. I am quite fit for my middle age. It’s a relative superpower which confers a degree of status in this world. It’s not why I originally became fit 5 or so years ago but it’s something I increasingly notice or to be clear others notice and comment on. I think the “fit” of the world get inherently uncomfortable that our relative social…

Well said. I believe you are right. That and ignorance of how Leptin works, setpoint or lipostat theory of bodyweight regulation...once you've gotten fat, your setpoint goes up and the hunger signals are far greater than folks who have never gotten fat. You can have 2 athletes with identical weight height and BF%, but if one had been fat once, their hunger signals from the brain will be far greater than the athlete who was always slim.

Re: Ozempic drug supresses desire to smoke, drink and more?

#425

Post by yieldcrv »

Earw0rm wrote: post #345
yieldcrv wrote: post #211

Earlier quoted context omitted.

can we do this for working out and exercise? I’m lean but dont do that and can recognize the benefits. It would be cool if we could pharmacologically make that appealing too. What if we could just continually swap in states. Executive work mode, ah it feels so good to think and focus. Empath mode, ah it feels so good to build relationships. Brolic mode, ah it feels so good to think about working out, and actually wor…

Find the right exercise/workout for you and it'll be its own reward. Shouldn't take more than a bit of caffeine to get you moving at that point. As to empath mode, you've just described MDMA. But it'd be nice if there were something a little less intense. That you could take weekly without frying your brain & was mild enough for family/work social situations. (And no, alcohol doesn't fit the bill).

> Find the right exercise/workout for you and it'll be its own reward.

appreciate the perspective but I want to be like the people that feel pulled to "find" it at all.

Re: Ozempic drug supresses desire to smoke, drink and more?

#426

Post by joedevon »

mym1990 wrote: post #5

A drug that promotes weight loss, lessens the desire to smoke, drink, etc...sounds too good to be true? From what I have heard, all of these issues come back as soon as someone comes off the drug. So either a person is committing to a lifetime of being dependent on this drug, or a person is committing to some period of time of ideal living, followed by a possible time of depression after reverting to the status quo.

Imagine being 250 lbs and feeling like you are starving constantly, despite eating a lot every day. You decide to lose weight. You do something you hate, like calorie restriction and working out like a dog. You lose 80 lbs in 1 year. Bravo. Everyone tells you how great you look. You feel great. All that hard work was worth it. The fatness and a million other things really motivated you to do the hard work. I've done this a couple of times.

Next day after hitting your goal, the starvation is still there. The desire to eat is still there. Hating working out is still there. But now you have to do this herculean effort every day not to get better. Not to lose weight. Just to maintain. Your brain wants you to gain 80 lbs and will never stop nagging you. Not on a good day. Not on a bad day.

Then something really shitty happens in your life. Like it does for everyone. You slip. Eventually you start to gain back the weight. You just want to die. You feel like a failure. You hate yourself.

That's the trick. Hitting goal weight the first time or two is relatively "easy". But you've achieved nothing if you aren't able to maintain weight loss. That's the failure of all approaches prior to these GLP1 and similar drugs.

Having set the scene, now compare it to semaglutide. You have a drug that regulates your brain. Gets rid of the constant nagging to eat. You get normal brain. You lose weight.

Now you have to pick, take a once a week drug for life to maintain, or do a herculean effort to fight the brain urges and work out to maintain.

Which do you think will be more successful?

Re: Ozempic drug supresses desire to smoke, drink and more?

#427

Post by [deleted] »

valec wrote: post #423
36933 wrote: post #395

Earlier quoted context omitted.

Ketamine treatments help people, because ketamine is a dissociative drug. It makes you not feel your suffering, also makes you not feel the positive feelings. That’s why you’re not eg doomscrolling. It doesn’t feel good for you anymore. If you’re not getting treatments regularly, you will be back to suffering in a few months likely. In my opinion, there are better alternatives and more effective treatments than livin…

this is not true at all. the dissociative effects only last a few hours. the clinical benefit is because ketamine stimulates neurogenesis in the mPFC and hippocampus, restoring plasticity lost in depressed patients. don't make unsubstantiated leaps :-)

[deleted]

Re: Ozempic drug supresses desire to smoke, drink and more?

#428

Post by [deleted] »

MagicMoonlight wrote: post #364
crazygringo wrote: post #112

Earlier quoted context omitted.

Yeah, that's definitely always been my challenge with weight loss. I have zero problem with self control -- I can easily cut calories in half or less (e.g. 1000-1200 cal/day), but it's simply that my body suffers immensely. I lose all energy, can't concentrate on anything, and my immune system weakens so I start getting colds constantly. I'm sure I'd easily lose weight with Ozempic but I'd still be suffering health i…

That sounds like a convenient excuse not to change

[deleted]

Re: Ozempic drug supresses desire to smoke, drink and more?

#429

Post by [deleted] »

yieldcrv wrote: post #211
ramraj07 wrote: post #196

Earlier quoted context omitted.

For a long time we have known the existence of a network of hormones controlling our apetite on the gut brain axis, with names like ghrelin, leptin, glp-1, orexin, somatostatin, list goes on [1]. Issue was the network was tres complicé and hard to perturb without getting the opposite effect than what we wanted. Finally with glp-1, sglt2 and pcsk9 inhibition we are starting to be able to correct in the right way. To a…

can we do this for working out and exercise? I’m lean but dont do that and can recognize the benefits. It would be cool if we could pharmacologically make that appealing too. What if we could just continually swap in states. Executive work mode, ah it feels so good to think and focus. Empath mode, ah it feels so good to build relationships. Brolic mode, ah it feels so good to think about working out, and actually wor…

[deleted]

Re: Ozempic drug supresses desire to smoke, drink and more?

#430

Post by 36933 »

valec wrote: post #423
36933 wrote: post #395

Earlier quoted context omitted.

Ketamine treatments help people, because ketamine is a dissociative drug. It makes you not feel your suffering, also makes you not feel the positive feelings. That’s why you’re not eg doomscrolling. It doesn’t feel good for you anymore. If you’re not getting treatments regularly, you will be back to suffering in a few months likely. In my opinion, there are better alternatives and more effective treatments than livin…

this is not true at all. the dissociative effects only last a few hours. the clinical benefit is because ketamine stimulates neurogenesis in the mPFC and hippocampus, restoring plasticity lost in depressed patients. don't make unsubstantiated leaps :-)

Yes the immediate effects last for a few hours. I didn’t say otherwise. The current scientific literature paints a mixed picture of ketamine. While it can stimulate neurogenesis, there is a definite potential for neurotoxicity. Not to mention that there are no long term studies out there. There are countless people reporting being anhedonic after treatments. Only a few people have been reported to not relapse before 24 weeks.

I’m not making unsubstantiated claims. Don’t accuse me of that, because you don’t like my answer.

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