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Ozempic drug supresses desire to smoke, drink and more?

theatlantic.com

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Re: Ozempic drug supresses desire to smoke, drink and more?

#311

Post by ddlutz »

hombre_fatal wrote: post #294
olegious wrote: post #278

Just a heads up “weight loss” is a poor metric if it comes at the cost of lean muscle mass. It seems that 39% of weight loss associated with Ozempic comes from lean muscle mass which isn’t great. https://peterattiamd.com/the-downside-of-glp-1-receptor-agon...

There's no shortage of people debunking that charlatan. https://twitter.com/MichaelAlbertMD/status/16470364172503040...

Why do you think Peter Attia is a charlatan? Out of all these longevity & health influencers he seems most realistic & knowledgeable.

Re: Ozempic drug supresses desire to smoke, drink and more?

#312

Post by CapstanRoller »

jmpman wrote: post #151

I’ve been on Mounjaro since August. Down almost 60lbs, and it’s been a life changer. Have I had some gastrointestinal issues, sure, but expected. I feel great and my brain seems to be functioning as well as when I was in my 20’s. Now, when I go to the bar with friends, I end up having maybe 2 beers and although enjoyable, I don’t feel that light switch turning on which encourages me to drink more. Can I force myself…

>I feel great and my brain seems to be functioning as well as when I was in my 20’s

>but my untreated ADHD seems to be getting worse.

I had very similar results after taking ketamine for treatment-resistant depression. It eliminated all my compulsive tendencies for getting cheap dopamine hits (food, doomscrolling, etc), reset my tolerance to everything (caffeine, ADHD meds, alcohol), and made my ADHD worse while improving throughput and ability to Get Shit Done.

I wonder if they affect the same parts of the brain in a roundabout way? Ketamine is also used to treat addiction (opioids, primarily).

Do you experience any anhedonia while using Mounjaro? Did your overall pleasure response get blunted?

Re: Ozempic drug supresses desire to smoke, drink and more?

#313

Post by rjbwork »

LazyMans wrote: post #155

Yes. On a compounded semaglutide. I can finally control my hunger and a nice unexpected effect has been losing a desire to drink large quantities of alcohol. I don’t drink during the week anyway, but it seems to be the volume that turns me off to drinking. Thus a few cocktails are all I can tolerate. For context, Im 30, male, would be defined as a binge drinker on weekends. Oh, and I’ve given up nicotine entirely. I…

Can you share this "compounded semaglutide" source? My doctor mentioned it but I'm a bit anxious about it. Everything out there seems so sketchy.

Re: Ozempic drug supresses desire to smoke, drink and more?

#315

Post by sneak »

Gud wrote: post #257
tremere wrote: post #252

[flagged]

Couldn’t agree more. Although I never suffered from obesity, I’ve lived a generally unhealthy lifestyle for most of my life. Slowly I’ve gotten my diet in order - not perfect, but a lot better. I haven’t had a smoke for three days, and frankly, it was easier to quit than I thought. I still get the impulse to go buy a pack, but I hold out and 20 minutes later that intrusive thought is gone. I don’t believe a pill woul…

No pill is as effective as having finally had enough of what you don't want.

Re: Ozempic drug supresses desire to smoke, drink and more?

#316

Post by r00tanon »

SystemOut wrote: post #183
lumb63 wrote: post #23

I’m glad people are enjoying Ozempic. My experience from seeing a family member on it, is I would not touch it if I were a 500-pound alcoholic smoking two packs of cigarettes a day. That’s an exaggeration since it probably outweighs the health issues there, but only slightly. The person I know taking Ozempic has only lost weight (35 lbs) due to the fact that eating now makes her sick. She has been sapped of all energ…

My story / anecdata. About 6 months ago there was a posting about Ozempic and I had said something to the effect that it wasn't worth it watching some of the side effects my wife had from it. And then I went to the doctor for a check-up and lo and behold I had diabetes. Asymptomatic, but an A1C of 11. My doctor re-ran the test because he didn't believe it and it doesn't run in my family. My cholesterol had also jumpe…

I have had a nearly identical experience. Thanks for sharing.

Re: Ozempic drug supresses desire to smoke, drink and more?

#317

Post by sneak »

standardUser wrote: post #31
mym1990 wrote: post #5

A drug that promotes weight loss, lessens the desire to smoke, drink, etc...sounds too good to be true? From what I have heard, all of these issues come back as soon as someone comes off the drug. So either a person is committing to a lifetime of being dependent on this drug, or a person is committing to some period of time of ideal living, followed by a possible time of depression after reverting to the status quo.

The first days, weeks and months are often the hardest time when quitting a substance. If this drug helps a smoker not smoke for 3 months, by that time the nicotine addiction has weakened considerably. They've gotten past the hardest part. I see no downside to that. Similarly, if a person loses 30 pounds on this drug, then stops using the drug and reverts to normal habits, it will take a while to regain those 30 poun…

Nicotine physical addiction is over with in less than a week. The remainder is psychological habit and classical conditioning.

Re: Ozempic drug supresses desire to smoke, drink and more?

#318

Post by nullc »

vrc wrote: post #108
lumb63 wrote: post #23

I’m glad people are enjoying Ozempic. My experience from seeing a family member on it, is I would not touch it if I were a 500-pound alcoholic smoking two packs of cigarettes a day. That’s an exaggeration since it probably outweighs the health issues there, but only slightly. The person I know taking Ozempic has only lost weight (35 lbs) due to the fact that eating now makes her sick. She has been sapped of all energ…

The risk of pancreatitis is also increased substantially [0]. And for people who may already be predisposed to pancreatitis but haven’t had an attack, severe pancreatitis has a 10-30% mortality rate [1]. But even mild acute pancreatitis will make you want to crawl out of your own skin in pain. [0] https://www.hopkinsmedicine.org/news/media/releases/johns_ho... [1] https://www.aafp.org/pubs/afp/issues/2007/0515/p1513.…

I'm somewhat dubious of the severe pancreatitis mortality rates-- the issue is that most cases of severe pancreatitis are caused by very severe alcoholism, and by the time the pancreatitis shows up everything else is already failing.

Re: Ozempic drug supresses desire to smoke, drink and more?

#319

Post by sneak »

glonq wrote: post #61

What happens when you reach your target weight with drugs like this? After having learned potentionally nothing about nutrition, exercise, and self-control, are you stuck on these meds for life out of fear of binge-eating back to your original weight? FWIW I'm on a hundred-pound roller coaster ride from 300lbs to 200lbs; currently ~215. I've learned a lot about discipline and sustainable habits along the way.

Not everyone that is overweight is overweight because of binge eating.

There is no data to suggest that those that don't engage in binge eating will suddenly begin doing so when ceasing this medication.

Re: Ozempic drug supresses desire to smoke, drink and more?

#320

Post by CapstanRoller »

sergiomattei wrote: post #269
AtlasBarfed wrote: post #159

Earlier quoted context omitted.

I'd hazard a guess that nicotine is one of the two or three most addictive substances known to humanity. Opiates/heroin is probably worse, world of warcraft is probably third :-) The drug probably helped.

Factorio is third.

The real message of the game is that to win you must abandon industrial society and make peace with the bugs.
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