Hacker News Board Hacker News, browsed like a classic message board
Live data from Hacker News

Ozempic drug supresses desire to smoke, drink and more?

theatlantic.com

Post reply on HN
Print view View original

141–150 of 504 posts

Re: Ozempic drug supresses desire to smoke, drink and more?

#141

Post by bluepizza »

iwanttocomment wrote: post #74
shagymoe wrote: post #66

Earlier quoted context omitted.

Have we though? I seriously doubt doctors are aggressively pushing eating well and exercising. Has anyone ever received a workout plan from their doctor besides some generic PT exercises? Do they develop nutrition plans tailored to you? Do they track your progress? Do they have any incentive for you to actually get better? Do they require regular blood tests and include all the tests that might actually tell them som…

I seriously doubt doctors are aggressively pushing eating well and exercising. Have you ever... been to a doctor when you've been obese? I assure you that they will indeed push eating well and exercising to obese people. Even when you've already been eating well and exercising. This will not be an intervention by the PCP themselves - your primary can really just refer people to substantial interventions - but they wi…

[flagged]

Re: Ozempic drug supresses desire to smoke, drink and more?

#142

Post by confoundcofound »

jasonfarnon wrote: post #125
akiselev wrote: post #121

Earlier quoted context omitted.

> The only intervention that does reliably work is bariatric surgery. My understanding is surgery only works reliably because failure to comply with life style changes post-op is easily fatal and ethical doctors only perform the operation after patients have demonstrated that ability. In all but the most extreme patients, about a fifth to a third of the target weight loss has to happen pre-op for doctors to even cons…

" failure to comply with life style changes post-op is easily fatal" My understanding is naive but I always thought it was no longer possible to fail to comply after this intervention?

You can rupture your GI sutures if you do not adhere to the post-op diet, and risk death.

Re: Ozempic drug supresses desire to smoke, drink and more?

#143

Post by ESTheComposer »

lumb63 wrote: post #23

I’m glad people are enjoying Ozempic. My experience from seeing a family member on it, is I would not touch it if I were a 500-pound alcoholic smoking two packs of cigarettes a day. That’s an exaggeration since it probably outweighs the health issues there, but only slightly. The person I know taking Ozempic has only lost weight (35 lbs) due to the fact that eating now makes her sick. She has been sapped of all energ…

I started Wegovy about 5 months ago. The first couple months you feel sick but after it passes your appetite is extremely curbed (in a good way). Would highly recommend people to try it as it's made me healthier in pretty much every way.

Re: Ozempic drug supresses desire to smoke, drink and more?

#144

Post by stavros »

znpy wrote: post #92
ortusdux wrote: post #58

Earlier quoted context omitted.

I remember grabbing a pamphlet when it was new and reading their recommendation to wear dark colored pants and bring a change of clothes to work.

Jesus Christ on a bike, that’s beyond dystopian, that’s completely f—-ked up. Does the fda allow that?

Yes, why would the FDA restrict what color pants you wear?

Re: Ozempic drug supresses desire to smoke, drink and more?

#145

Post by Retric »

znpy wrote: post #92
ortusdux wrote: post #58

Earlier quoted context omitted.

I remember grabbing a pamphlet when it was new and reading their recommendation to wear dark colored pants and bring a change of clothes to work.

Jesus Christ on a bike, that’s beyond dystopian, that’s completely f—-ked up. Does the fda allow that?

There’s huge tradeoffs people rarely talk about in Medicine. Significant risk of soiling yourself vs a statistically significant reduction in risk of early death isn’t a big deal for the FDA.

In many cases the hell that is chemo is considered acceptable for even moderate increases in expected lifespan. That’s why people started talking healthy life expectancy vs just life expectancy.

Re: Ozempic drug supresses desire to smoke, drink and more?

#146

Post by ESTheComposer »

SamoyedFurFluff wrote: post #131

How long is the research info ozempic and other hormonal weight loss drugs? Remember the last miracle drug that went to the market for weight loss had to be retracted for killing people or damaging their hearts to the tune of over 10 billion dollars in damages paid out.

These types of medications have been around since the 2000s, semaglutide (ozempic) specifically since 2012.

Re: Ozempic drug supresses desire to smoke, drink and more?

#147

Post by SOLAR_FIELDS »

aplusbi wrote: post #28
mym1990 wrote: post #5

A drug that promotes weight loss, lessens the desire to smoke, drink, etc...sounds too good to be true? From what I have heard, all of these issues come back as soon as someone comes off the drug. So either a person is committing to a lifetime of being dependent on this drug, or a person is committing to some period of time of ideal living, followed by a possible time of depression after reverting to the status quo.

A lot of addiction is caused by social issues or mental health issues, but it's really hard to deal with those issues when someone is also dealing with the effects of addiction. A drug like this could provide an opportunity to fix the underlying issues causing addiction in the first place. And for some people they will have to take this for life, which isn't so different from many other medications.

Yeah, I honestly don’t see a problem with taking a drug for life, as long as the side effects are minimal and the logistics are simple. I’m in my early 30’s and have a family history of bad cholesterol. So once a day I will take a statin for the rest of my life. Not a problem, little to no side effects and pretty easy to manage, and not the end of the world if I miss one day every so often. Twice a day is not so easy to manage and plan but once a day is definitely manageable for a lot of people

Re: Ozempic drug supresses desire to smoke, drink and more?

#148

Post by dillydogg »

SamoyedFurFluff wrote: post #131

How long is the research info ozempic and other hormonal weight loss drugs? Remember the last miracle drug that went to the market for weight loss had to be retracted for killing people or damaging their hearts to the tune of over 10 billion dollars in damages paid out.

At least in this case GLP-1 antagonists have been in clinical use for diabetes since around 2010

Re: Ozempic drug supresses desire to smoke, drink and more?

#149

Post by mattzito »

vrc wrote: post #108
lumb63 wrote: post #23

I’m glad people are enjoying Ozempic. My experience from seeing a family member on it, is I would not touch it if I were a 500-pound alcoholic smoking two packs of cigarettes a day. That’s an exaggeration since it probably outweighs the health issues there, but only slightly. The person I know taking Ozempic has only lost weight (35 lbs) due to the fact that eating now makes her sick. She has been sapped of all energ…

The risk of pancreatitis is also increased substantially [0]. And for people who may already be predisposed to pancreatitis but haven’t had an attack, severe pancreatitis has a 10-30% mortality rate [1]. But even mild acute pancreatitis will make you want to crawl out of your own skin in pain. [0] https://www.hopkinsmedicine.org/news/media/releases/johns_ho... [1] https://www.aafp.org/pubs/afp/issues/2007/0515/p1513.…

So I was able to find an aggregate of the study results:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8294388/

out of an n of >3000 patients getting medication, 34 ended up having some form of pancreatitis. At least 12 people on placebo got pancreatitis. That's a much higher rate, but the odds are still pretty low.

Re: Ozempic drug supresses desire to smoke, drink and more?

#150

Post by refurb »

kristofferR wrote: post #39
rektide wrote: post #9

I'm surprised Ozempic gets all the press. Supposedly Mounjaro is all that and more. The wonderful Paul Ford has the best writeup I've seen that discusses these more meta levels, the post-human implications of a drug we can genuinely widescalely reprogram ourselves with. Paul's so great. https://www.wired.com/story/new-drug-switched-off-appetite-m... https://news.ycombinator.com/item?id=34660232

Massive text: "People taking Mounjaro lost up to 25 LBS" Small text underneath: "Mounjaro is not a weight loss drug." Man, the US pharma industry/marketing is so weird. https://www.mounjaro.com/#:~:text=mounjaro%20is%20not%20a%20... .

It’s not weird at all if you’re aware of the regulations.

Drug companies can’t promote a drug for something it’s not FDA approved for (off-label promotion). Companies face multi-billion dollar penalties for doing so.

Mounjaro is approved for type 2 diabetes. And weight loss is a great way to help get your type 2 diabetes under control.

So highlighting that it helps type 2 patients lose weight, while having an FDA mandated disclosure that it’s not approved for weight loss alone, makes perfect sense.

Post reply on HN