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T cells can activate themselves to fight tumors

today.ucsd.edu

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Re: T cells can activate themselves to fight tumors

#11

Post by tysam_and »

pazimzadeh wrote: post #2

> Through a series of experiments, the researchers found that T cells could indeed self-activate by puckering their cell membrane inwards to allow the B7 protein and the CD28 receptor to bind to each other Very cool, but doesn't this imply that T-cells can also activate other T-cells that are nearby? (in trans) Edit: in the actual paper they said "We generated reporter Jurkat lines and Raji APCs stably expressing CD8…

I'm pretty sure I've heard that they can, I have no source for this though. I wonder if this is linked to phenomena such as spontaneous degranulation in the complete absence of an antigen in mast cell disorders (once again, not positive this is a thing, but I believe it is).

Though on that last point IIRC, I believe I've heard it also just has to do a bit with random conformational noise on the receptors causing autoactivation.

Re: T cells can activate themselves to fight tumors

#12

Post by chasil »

hn_throawlles wrote: post #3

but when this happens in real life, it looks like mass shootings i.e., I'm saying (due to how I think) that in the layer of the cells, like the biological cells that come together to form one human, a T cell activates itself to fight tumors (damaged tissues? organism mistakes?)... is somehow comparable to a human person snaps, "goes postal", or things like this. (keep in mind that some places are truly deep within th…

There is nothing in the behavior of cells that is reflective of human intelligence.

Cells are "amino acid robots."

They string the 26 programmed amino acids into exotic plastics/proteins to execute their programmed functions.

There is no relation to human behavior in cellular behavior.

At the end of an infection, most immune cells trigger "apoptosis" (controlled cellular "suicide").

At the end of a riot, police obviously do not do this.

You might find this Kurzgesagt introduction to immune system behavior interesting. There are several videos in this sequence, and Kurzgesagt ultimately published a book that is worth reading.

https://m.youtube.com/watch?v=lXfEK8G8CUI

Re: T cells can activate themselves to fight tumors

#13

Post by pazimzadeh »

tysam_and wrote: post #11
pazimzadeh wrote: post #2

> Through a series of experiments, the researchers found that T cells could indeed self-activate by puckering their cell membrane inwards to allow the B7 protein and the CD28 receptor to bind to each other Very cool, but doesn't this imply that T-cells can also activate other T-cells that are nearby? (in trans) Edit: in the actual paper they said "We generated reporter Jurkat lines and Raji APCs stably expressing CD8…

I'm pretty sure I've heard that they can, I have no source for this though. I wonder if this is linked to phenomena such as spontaneous degranulation in the complete absence of an antigen in mast cell disorders (once again, not positive this is a thing, but I believe it is). Though on that last point IIRC, I believe I've heard it also just has to do a bit with random conformational noise on the receptors causing auto…

You might be thinking of NK T-cells?

Re: T cells can activate themselves to fight tumors

#14

Post by dp-hackernews »

chasil wrote: post #12
hn_throawlles wrote: post #3

but when this happens in real life, it looks like mass shootings i.e., I'm saying (due to how I think) that in the layer of the cells, like the biological cells that come together to form one human, a T cell activates itself to fight tumors (damaged tissues? organism mistakes?)... is somehow comparable to a human person snaps, "goes postal", or things like this. (keep in mind that some places are truly deep within th…

There is nothing in the behavior of cells that is reflective of human intelligence. Cells are "amino acid robots." They string the 26 programmed amino acids into exotic plastics/proteins to execute their programmed functions. There is no relation to human behavior in cellular behavior. At the end of an infection, most immune cells trigger "apoptosis" (controlled cellular "suicide"). At the end of a riot, police obvio…

This short series is a bit more in depth...

https://www.youtube.com/playlist?list=PLFtH1mhd9gD_064ndQ9Te...

Re: T cells can activate themselves to fight tumors

#15

Post by [deleted] »

chasil wrote: post #12
hn_throawlles wrote: post #3

but when this happens in real life, it looks like mass shootings i.e., I'm saying (due to how I think) that in the layer of the cells, like the biological cells that come together to form one human, a T cell activates itself to fight tumors (damaged tissues? organism mistakes?)... is somehow comparable to a human person snaps, "goes postal", or things like this. (keep in mind that some places are truly deep within th…

There is nothing in the behavior of cells that is reflective of human intelligence. Cells are "amino acid robots." They string the 26 programmed amino acids into exotic plastics/proteins to execute their programmed functions. There is no relation to human behavior in cellular behavior. At the end of an infection, most immune cells trigger "apoptosis" (controlled cellular "suicide"). At the end of a riot, police obvio…

[deleted]

Re: T cells can activate themselves to fight tumors

#16

Post by chasil »

dp-hackernews wrote: post #14
chasil wrote: post #12

Earlier quoted context omitted.

There is nothing in the behavior of cells that is reflective of human intelligence. Cells are "amino acid robots." They string the 26 programmed amino acids into exotic plastics/proteins to execute their programmed functions. There is no relation to human behavior in cellular behavior. At the end of an infection, most immune cells trigger "apoptosis" (controlled cellular "suicide"). At the end of a riot, police obvio…

This short series is a bit more in depth... https://www.youtube.com/playlist?list=PLFtH1mhd9gD_064ndQ9Te...

I saw the first episode.

This skips around, and misses major aspects that are barely mentioned.

The compliment system has it's own video in the Kurzgesagt series, although it misses a major aspect in a "membrane attack complex" in the participation of an antibody.

This first entry in the series that you've posted focuses on the innate immune system, but barely mentions compliment, and doesn't mention C-3 or a membrane attack complex. Dendritic cells are also left out, but they may be in another episode.

I'll watch the rest of the series, but I think that Kurzgesagt has more focus.

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