T cells can activate themselves to fight tumors
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T cells can activate themselves to fight tumors
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Re: T cells can activate themselves to fight tumors
#2> Through a series of experiments, the researchers found that T cells could indeed self-activate by puckering their cell membrane inwards to allow the B7 protein and the CD28 receptor to bind to each other
Very cool, but doesn't this imply that T-cells can also activate other T-cells that are nearby? (in trans)
Edit: in the actual paper they said "We generated reporter Jurkat lines and Raji APCs stably expressing CD80, CD86, or neither (Figure S2A), enabling coculture conditions in which the B7 ligand was presented to CD28 in cis, in trans, or both. To minimize potential trans-B7:CD28 interactions between T cells, we cultured Jurkat reporter cells with 100-fold excess of Raji APCs"
However, the point remains that in vivo, T-cells would be able to do both the cis and trans activation. Which is still novel, I think?
Re: T cells can activate themselves to fight tumors
#3but when this happens in real life, it looks like mass shootings
i.e., I'm saying (due to how I think) that in the layer of the cells, like the biological cells that come together to form one human, a T cell activates itself to fight tumors (damaged tissues? organism mistakes?)...
is somehow comparable to a human person snaps, "goes postal", or things like this. (keep in mind that some places are truly deep within the 'cancer tissue'; and yea, this whole comment implies viewpoint that 'civilization is cancer' or something like that)
I've seen some movies that could be like this too, like "sleeper agent gets activated" trope, or other kinds of anamnesis-processes making people suddenly act far from the norms
Re: T cells can activate themselves to fight tumors
#4Wasn't this already known, or at least suspected? I thought the bigger unknown was how to activate the T-cells, since tumor cells are very good at masking like normal tissue. The article lightly touches on that (when talking about the process of T-cell self-activation), but it still doesn't specify on how to control that targeting.
So I'm not sure how the research matches the headline. What's the link that I'm missing? Yes, T-cells can activate themselves, which has implications both for tumors and for auto-immune diseases (which was the first thought that came to me while reading), but this research does not actually bring us closer to weaponizing them?
Re: T cells can activate themselves to fight tumors
#5Wasn't this already known, or at least suspected? I thought the bigger unknown was how to activate the T-cells, since tumor cells are very good at masking like normal tissue. The article lightly touches on that (when talking about the process of T-cell self-activation), but it still doesn't specify on how to control that targeting. So I'm not sure how the research matches the headline. What's the link that I'm missin…
I don't think it was known that co-stimulation can happen with only one partner
Re: T cells can activate themselves to fight tumors
#6Thought some gets suppressed in certain types
Re: T cells can activate themselves to fight tumors
#7Wasn't this already known, or at least suspected? I thought the bigger unknown was how to activate the T-cells, since tumor cells are very good at masking like normal tissue. The article lightly touches on that (when talking about the process of T-cell self-activation), but it still doesn't specify on how to control that targeting. So I'm not sure how the research matches the headline. What's the link that I'm missin…
I don't think it was known that co-stimulation can happen with only one partner
Speak for yourself.
Re: T cells can activate themselves to fight tumors
#8Re: T cells can activate themselves to fight tumors
#9Thought some gets suppressed in certain types
this is in a dish, not in vivo
Re: T cells can activate themselves to fight tumors
#10> Through a series of experiments, the researchers found that T cells could indeed self-activate by puckering their cell membrane inwards to allow the B7 protein and the CD28 receptor to bind to each other Very cool, but doesn't this imply that T-cells can also activate other T-cells that are nearby? (in trans) Edit: in the actual paper they said "We generated reporter Jurkat lines and Raji APCs stably expressing CD8…
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