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Effect of LSD on reinforcement learning in humans (2022)

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Re: Effect of LSD on reinforcement learning in humans (2022)

#11

Post by quchen »

tiku wrote: post #9

I'm more scared of LSD than ever before, after hearing about that you see "scanlines" for ever after using it. Anyone got this after? https://www.insider.com/9-years-after-acid-trip-man-has-pers...

I'm neither a fan of drug glorification nor FUD. The link is from someone who took lots of different substances very irresponsibily,

> I got some acid from a friend of a friend. It was some sort of pink substance smudged on the back of an Altoid, and I just popped the whole mint in my mouth.

AKA "a completely unknown pill with a friend's opinion".

Re: Effect of LSD on reinforcement learning in humans (2022)

#12

Post by speed_spread »

kweingar wrote: post #6
Buhljingo wrote: post #3

Would love to see this type of experiment performed across different dosages, 25 μg -200 μg. I think the "positive" effects would take a big, sudden drop after a certain threshold

Where can I sign up to participate in a study that involves taking 200 ug of LSD? :)

There are multiple clinics on Wall Street, I hear.

Re: Effect of LSD on reinforcement learning in humans (2022)

#13

Post by thendrill »

Buhljingo wrote: post #3

Would love to see this type of experiment performed across different dosages, 25 μg -200 μg. I think the "positive" effects would take a big, sudden drop after a certain threshold

Same thing is observed with about 0.2 V and cpu overcloking... Suddenly there is a performance drop.

Re: Effect of LSD on reinforcement learning in humans (2022)

#14

Post by Broken_Hippo »

tiku wrote: post #9

I'm more scared of LSD than ever before, after hearing about that you see "scanlines" for ever after using it. Anyone got this after? https://www.insider.com/9-years-after-acid-trip-man-has-pers...

I've done a fair amount of LSD, over years. I'm in my mid-40s, and it hasn't been all that long.

I've never had this. My partner - the person I've done it with the most - hasn't either. Nor have I known anyone.

That said, it isn't like I think this person is lying, but that it is something rare, as the article admits to at the end.

I'm not really trying to make you less scared - you do you, and don't do a drug you don't want to do - but trying to give some perspective.

Re: Effect of LSD on reinforcement learning in humans (2022)

#15

Post by Broken_Hippo »

riedel wrote: post #2

No expert, but I had some immediate questions when reading this. Wasn't the dose high enough to be easily distinguishable from the placebo without any experience? Why not some other drug a palcebo? Is single blind design actually advisable in such a study? Can someone enlighten me?

I'd think there were two ways to produce this.

The first would be to not disclose the dose. If you don't know the dose, you might just assume it is a low dose and you aren't getting effects. This is especially easy to pull off since a lot of folks know about microdosing - which usually has the goal of not-too-much-hallucination.

Second, you can get folks new to LSD in combination with the above.

I'd think that the issue with giving another drug is that we wouldn't know how that drug is going to affect the outcome. You still need the baseline of sober folks to compare to, and given them a fake dose means that the ones that will have the placebo effect, will.

Re: Effect of LSD on reinforcement learning in humans (2022)

#16

Post by jokowueu »

tiku wrote: post #9

I'm more scared of LSD than ever before, after hearing about that you see "scanlines" for ever after using it. Anyone got this after? https://www.insider.com/9-years-after-acid-trip-man-has-pers...

Aside from fud the only thing that is known among psychadelic users is visual snow ( one of the hallmarks of HPPD) . this sometimes happens after extremely high doses of psychadelics

Re: Effect of LSD on reinforcement learning in humans (2022)

#17

Post by throwaway50606 »

Broken_Hippo wrote: post #15
riedel wrote: post #2

No expert, but I had some immediate questions when reading this. Wasn't the dose high enough to be easily distinguishable from the placebo without any experience? Why not some other drug a palcebo? Is single blind design actually advisable in such a study? Can someone enlighten me?

I'd think there were two ways to produce this. The first would be to not disclose the dose. If you don't know the dose, you might just assume it is a low dose and you aren't getting effects. This is especially easy to pull off since a lot of folks know about microdosing - which usually has the goal of not-too-much-hallucination. Second, you can get folks new to LSD in combination with the above. I'd think that the is…

If you have any hallucinations at all, you're not microdosing. Microdosing is right before the tipping point of recognizing you took something at all. It should be recognizable from long-term effects, not immediately.

Re: Effect of LSD on reinforcement learning in humans (2022)

#18

Post by throwawayadvsec »

throwaway50606 wrote: post #17
Broken_Hippo wrote: post #15

Earlier quoted context omitted.

I'd think there were two ways to produce this. The first would be to not disclose the dose. If you don't know the dose, you might just assume it is a low dose and you aren't getting effects. This is especially easy to pull off since a lot of folks know about microdosing - which usually has the goal of not-too-much-hallucination. Second, you can get folks new to LSD in combination with the above. I'd think that the is…

If you have any hallucinations at all, you're not microdosing. Microdosing is right before the tipping point of recognizing you took something at all. It should be recognizable from long-term effects, not immediately.

I wonder if there is more data about this.

A while ago I've microdosed 1 to 2g of fresh truffles(which should not induce a trip), a few days/weeks after a real trip, and I had some hallucinations, which should not have happened

IDK, is it possible that a microdose could trigger some kind of a release of a previous buildup of some hallucinogens?

Re: Effect of LSD on reinforcement learning in humans (2022)

#19

Post by throwawayadvsec »

kweingar wrote: post #5
riedel wrote: post #2

No expert, but I had some immediate questions when reading this. Wasn't the dose high enough to be easily distinguishable from the placebo without any experience? Why not some other drug a palcebo? Is single blind design actually advisable in such a study? Can someone enlighten me?

> Wasn't the dose high enough to be easily distinguishable from the placebo without any experience? This was my first thought. There’s no way that anybody would mistake 75 ug of LSD for placebo.

I'm not sure about this. I'm a big guy, I barely feel 100 ug, if I didn't know what LSD was like I could easily not notice

Re: Effect of LSD on reinforcement learning in humans (2022)

#20

Post by hereforcomments »

tiku wrote: post #9

I'm more scared of LSD than ever before, after hearing about that you see "scanlines" for ever after using it. Anyone got this after? https://www.insider.com/9-years-after-acid-trip-man-has-pers...

"My whole mouth went numb" This is a very strong indication for taking NBOME instead of LSD. From the article: "Looking back, I'm pretty certain that what I tried was not LSD." LSD would never numb your mouth. Just Google "LSD mouht numb reddit". Also, there's no lethal does of LSD, NBOM can easily kill you or screw you up just like in the article.

Everyone should always test thier substances before taking them to prevent these stories.

So do not fear LSD, fear NBOME.

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