Yes, this is a major unsolved problem to my eye. The cost of living in Columbus - while nowhere near the craziness of coastal cities - is steadily rising. Real estate in surrounding cities is also going up, and it's hard for me to imagine how all those working the jobs that will supposedly be created by the fabs will afford to live near them.
One development in Ohio has been a proposal for a passenger rail line that would connect Cincinnati, Columbus, and Cleveland. I'm originally from Crestline - a small town which sits right on the rail line between Columbus and Cleveland, and which used to be a big railroad town. It's interesting to think of how my hometown might change if passenger rail were to actually happen (though I'm skeptical, as versions of this plan have been proposed for decades).
That said, there are some major problems to overcome if we wanted to start doing "state-scale" transportation like that - Columbus is a very car-centric city, and in the scenario where I would move home and ride the train to Columbus when I needed to go to the office, it's very unclear how I'd get from the station to wherever I'm going.
Furthermore, there was just a very public and catastrophic train derailment in Ohio, which can't do much good for public confidence in commuter trains.
Either way, the next decade or so in Ohio will certainly be interesting. Columbus has a burgeoning tech community with lots of VC investment, and while I'm not sure where I'd put the odds, it's not impossible that our little flyover state could become the proverbial "heartland tech hub".