iirc there was a famous case where an outage occurred at a company using some least connection or least resource algorithm in the load balancers. The load balancer queue'd up requests and when a new server was brought online it immediately dos'd it out of existence. Then another server was brought online and the same thing occurred and another and another. They eventually switched to round-robin to give the new serve…
The topic is definitely much more complex than what I was able to cover in a single post :)