Billy Beane's shit doesn't work in the playoffs, the book/movie ignored the Big Three, and information advantages go away. The startup corollaries: small-bore inefficiencies can't overcome luck and strong competition, don't attribute success to A when it's really the obvious B (i.e. what differentiates your product doesn't mean it's actually better - Gowalla and foursquare is my favorite example here), and people wil…
Billy Beane's shit doesn't work in the playoffs What is this supposed to mean? The season gives you a 162-game sample. The playoffs are a coin-flip, by comparison. It's just too small of a sample to draw any conclusions, which is why both old- and new-school baseball guys have an endless array of cliches about how anybody who makes it in to the playoffs has a chance to win.
Beane and the A's were mostly focusing on offense, because that's were they could find value. It's significantly harder to find value in pitchers, and pitchers can help damper some of the "luck" factors in the postseason, though it's very much open to randomness.
Modern baseball management is focused on building your team to win enough regular seasons to make the postseason, and then hope luck falls in your direction. If you can couple that with great starting pitching, you can reduce the amount of luck you need.
I'm not sure how relevant the techniques in Moneyball still are. At this point, every team is looking at Sabermetrics, and some of the high-value stuff isn't there any more. For example, getting on base isn't worth as many runs in 2011 as it was in 2002 because there are less home runs hit.