281–290 of 291 posts
When you say in 2023 that they have "new insights" as to why a common over the counter drug works it really doesn't instill great confidence in pharma. Seems like we're still grinding up rhino horns and tiger penis and hoping for the best outcome, just that we do it with extensive testing now so we get a statistically acceptable outcome viable for marketing.
"it can cause detrimental side effects such as internal bleeding and organ damage" NSAIDs are also ototoxic, meaning that they cause hearing damage.
... and it has not become common knowledge yet that ibuprofen is not recommended for males due to its reductive effect on testosterone production
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Thanks - this type of reply is what separates Reddit from HN
You can find this kind of reply on Reddit if you’re in the right subreddit. /r/science and /r/drugnerds come to mind as potential candidates.
When you say in 2023 that they have "new insights" as to why a common over the counter drug works it really doesn't instill great confidence in pharma. Seems like we're still grinding up rhino horns and tiger penis and hoping for the best outcome, just that we do it with extensive testing now so we get a statistically acceptable outcome viable for marketing.
No. Science has all along been testing if something works and then finding out why. Often the „why“ is orders of magnitudes harder to find out than the „if“. For example, we can observe how the brain functions in some instances, but why it works like does will elude us perhaps forever. Highly complex systems like the inner biomechanical workings of our brains are essentially a black box.
"it can cause detrimental side effects such as internal bleeding and organ damage" NSAIDs are also ototoxic, meaning that they cause hearing damage.
You just sent me on a research adventure. I have struggled with chronic neck tension and pain for the last 15 years with no obvious origin event, and sometimes take 2-3 ibuprofen every day to take the edge off, when it's at its worst. Thank you for bringing this up! Background for me for those interested: Within a few years of struggling with chronic pain and tension headache episodes (vomiting, catch-my-breath level…
Earlier quoted context omitted.
You just sent me on a research adventure. I have struggled with chronic neck tension and pain for the last 15 years with no obvious origin event, and sometimes take 2-3 ibuprofen every day to take the edge off, when it's at its worst. Thank you for bringing this up! Background for me for those interested: Within a few years of struggling with chronic pain and tension headache episodes (vomiting, catch-my-breath level…
What you describe sounds complex, but for the vertigo part, check out BPPV (benign paroxysmal positional vertigo). If you have seen an ENT, they've probably covered this base, but even though it's the most common cause of vertigo-induced trips to the ER, my ER doc didn't cover it. It was two weeks before I saw an ENT who basically fixed it with the Epley maneuver. "Basically fixed" because I still have some lingering…
Yeah, Ménière’s and BPPV has been ruled out, thankfully.
The oddity is that the sets of symptoms waxes and wanes on the order of months. I had sudden hypertension (170/100, not overweight, ~155lbs and 5'9, decently healthy diet for sodium, etc) from 2016-2019, then within a couple months it completely disappeared and went back to normal (120/65). No known or significant changes in diet or lifestyle when it dropped or leading up to it.
I've kind of just "accepted" that I will have these various, "random" health issues, and am just doing my best to figure things out / mitigate them as they come along. The neck-tension-turning-into these "cervicogenic headaches" are the largest common hurdle to my life on a frequent basis. I can deal with the other noise of issues.
Anyway. Thanks again for responding!
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You just sent me on a research adventure. I have struggled with chronic neck tension and pain for the last 15 years with no obvious origin event, and sometimes take 2-3 ibuprofen every day to take the edge off, when it's at its worst. Thank you for bringing this up! Background for me for those interested: Within a few years of struggling with chronic pain and tension headache episodes (vomiting, catch-my-breath level…
I've had similar issues a while ago and I was able to resolve them. Of course everyone is different but in case you want to check: for me the cause was that my bite was off, not balanced across all teeth and my jaw was being pushed back. I Resolved it by re-aligning the teeth, moving jaw forward and having special retainer that I can clench on at night without issues.
My teeth don't grind at night, but the next time I head to the dentist I'll look into seeing if I can have the issue corrected... worth a shot!
Thanks for the suggestion!
Edit for more info:
My wife helps out with back and neck massages, and my traps (neck and between the shoulder blades) usually have knots on the days I have trouble. I plan on ruling out weak traps and other muscular imbalances for good this spring, but as I mentioned in my initial comment, I have had three different rounds of PT sessions with different workout strategies over the last decade, and still no resolution (nor improvement during/after).
This tension thing waxes and wanes just like the other symptoms, but far more frequently.
Aspirin has been a life changer for long Covid. The other painkillers make symptoms 10x worse. Many people wonder if aspirin anti platelet/blood thinning capabilities is helping breakup microclots which brings relief. There’s also a thing called nattokinase that apparently has similar properties to aspirin and is being studied for heart disease. It has been shown to break down blood clots and even degrade the spike p…
Aspirin+Claritin was what I used when I had a few weeks of extended COVID effects past the actual infection. It really does seem to work! Or at least I think I had it... I never actually tested, I just assumed I should probably isolate regardless of whether it was COVID or the flu.
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I totally concur. Got a condition comparable to yours and ibuprofen makes a real difference whereas paracetamol just doesn't do anything. Dunno why.
Does it have an inflammatory component? Paracetamol is an analgesic and antipyretic, but it is not anti-inflammatory. And there are other divergences e.g. ibuprofen has been linked to protecting against Parkinson’s, where neither paracetamol nor aspirin (which is an anti-inflammatory) have shown such property. The TLDR is that they’re different molecules, and while they have overlap in their antipyretic and analgesic…