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New insights into why aspirin works so well

eurekalert.org

271–280 of 291 posts

Re: New insights into why aspirin works so well

#271

Earlier quoted context omitted.

This site is about spreading false and misleading information under the guise of "just giving helpful advice"? Thanks but I'll continue to call out dangerous misinformation when I see it. Let's keep "reefer madness, but for pain medicine" at the fringes.

[flagged]

Strawman. There’s a whole world between “this thing is harmless and 100% beneficial” and “this thing is dangerous in all situations and will always lead down dark pathways.”

Re: New insights into why aspirin works so well

#272
post #155

Earlier quoted context omitted.

10:1 is still a pretty big ratio. You could take 20 Panadol every few hours before getting sick. That’s a LOT.

not really. you will be quite sick before you hit 10. also, double dosing is a major problem and makes it easier to hit the threshold .

Is the definition of “toxicity ratio” not “ratio of therapeutic dose to the amount required for toxic effects”?

Re: New insights into why aspirin works so well

#273

"it can cause detrimental side effects such as internal bleeding and organ damage" NSAIDs are also ototoxic, meaning that they cause hearing damage.

... and it has not become common knowledge yet that ibuprofen is not recommended for males due to its reductive effect on testosterone production

Re: New insights into why aspirin works so well

#274

"it can cause detrimental side effects such as internal bleeding and organ damage" NSAIDs are also ototoxic, meaning that they cause hearing damage.

You just sent me on a research adventure. I have struggled with chronic neck tension and pain for the last 15 years with no obvious origin event, and sometimes take 2-3 ibuprofen every day to take the edge off, when it's at its worst. Thank you for bringing this up! Background for me for those interested: Within a few years of struggling with chronic pain and tension headache episodes (vomiting, catch-my-breath level…

What you describe sounds complex, but for the vertigo part, check out BPPV (benign paroxysmal positional vertigo). If you have seen an ENT, they've probably covered this base, but even though it's the most common cause of vertigo-induced trips to the ER, my ER doc didn't cover it. It was two weeks before I saw an ENT who basically fixed it with the Epley maneuver. "Basically fixed" because I still have some lingering (and annoying) effects that echo some of the other symptoms you describe. BPPV is unique in my experience of medicine in that it has a simple test (Dixie-Hallpike maneuver), and an easy fix.

The other thing that comes to mind is Ménière’s disease, a disease affecting the pressures of the inner ear. It's probably also considered if you've seen an ENT. A friend worked on his Ménière’s with diet (low salt, low glycemic index foods), and diuretics, but what is helping now is allergy shots. His ENT noticed that there was a seasonal component to his symptoms and sent him to an allergist. (The first allergist he went to did testing but found nothing; the next allergist found plenty of reactions and hit on an effective treatment.) Actually, his symptoms sound quite similar to yours. The Mayo clinic page on Ménière’s mentions various treatment modalities, though not allergy treatment.

Re: New insights into why aspirin works so well

#275
post #207

Earlier quoted context omitted.

Do you have any good literature on Aspirin and LC? Not a doubter, actually I have LC myself.

I do not. I have my personal anecdote and experiences with common painkillers and LC. I've had it since January 2021 so there wasn't really anything known when I started taking aspirin outside of the many years of research as mentioned in OP's article. Here's my experience so far. https://jondouglas.dev/long-covid/ I've swapped aspirin about a year in for nattokinase and have noticed much better management. I still t…

The degradation effect paper is authored by among others James Yu, Kate Hsu, Shinder Chen (employees of NK producer) and Ayako Ishii (company involved in NK supply chain). Take it with a grain of salt.

Re: New insights into why aspirin works so well

#276
post #193

Earlier quoted context omitted.

Honestly, aspirin is really closer to "grinding up rhino horns" than to complex pharmaceuticals you have to make in a lab. It's literally "drink this tea made from willow bark" except we got better at isolating the active components and finding other ways to produce them and more reliably measuring the dosage. The difference is that empirical studies have demonstrated the effect of "willow bark tea" and the lack of a…

That's not technically true, willow has salicin in it. Aspirin is intentionally a slight modification.

Yes, penicilin is probably a better example.

Re: New insights into why aspirin works so well

#277
post #31

Earlier quoted context omitted.

believe me, i know all about pain, from experience. cannabis derived products are not going to do anything, and i have no idea what you were going on about with tumeric. the only real actual pain-killers are opioids.

You say only but I would say alcohol is decent at pain reduction in a lot of cases.

Ethanol seems to be an anti-inflammatory drug:

https://heart.bmj.com/content/90/4/355

Re: New insights into why aspirin works so well

#278

Earlier quoted context omitted.

Aspirin+Claritin was what I used when I had a few weeks of extended COVID effects past the actual infection. It really does seem to work! Or at least I think I had it... I never actually tested, I just assumed I should probably isolate regardless of whether it was COVID or the flu.

Tests are plentiful and easy. If you think you have it, get a test and find out. You still did the right thing by isolating, but advocating for aspirin and Claritin as relief for covid while not actually knowing for sure you had it is not as good. In fact, it can be dangerous, given those two drugs may interact with things others take but then read this and assume it's an effective treatment. You could have just been…

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Re: New insights into why aspirin works so well

#279

Aspirin has been a life changer for long Covid. The other painkillers make symptoms 10x worse. Many people wonder if aspirin anti platelet/blood thinning capabilities is helping breakup microclots which brings relief. There’s also a thing called nattokinase that apparently has similar properties to aspirin and is being studied for heart disease. It has been shown to break down blood clots and even degrade the spike p…

Along these lines, you might have even better luck with serrapeptase, which breaks down fibrin protein. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8265778/ These are known tissue plasminogen activators. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5553328/table/t...

Thank you. I do take this “silkworm supplement” in addition to NK. Thanks for sharing some research behind it. I hadn’t come across it yet.

Re: New insights into why aspirin works so well

#280

I use nothing for reducing inflammation, nor any drugs since decades, when I'm ill from time to time (once or twice a year), I let the fever go, the body is just working actively, it's not especially uncomfortable

I'm sure you didn't mean it this way, but this does read as if you're shaming people for using painkillers. No-one should have to endure pain and there's nothing wrong with the responsible use of drugs to reduce it.

I don't see it in his (downvoted) comment. It's getting unhealthy. Nowadays you need to be super careful when you write to not possibly offend anyone the tiniest bit. It's fuc*ed up.
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