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New insights into why aspirin works so well

eurekalert.org

261–270 of 291 posts

Re: New insights into why aspirin works so well

#261
Fun fact:

They would give Aspirin to Tzar Nikolas II's (or III?) son who suffered from hemophilia.

Came Rasputin the mystic around the corner and advised the Tzar's wife to keep the doctors off her son. As she did, her son miraculously recovered to a great degree.

Turns out little did they know Aspirin actually worsenes hemophilia due to thinning the blood.

Re: New insights into why aspirin works so well

#262
post #36

Earlier quoted context omitted.

Prevents arachidonic acid from being converted to thromboxane needed for platelet aggregation. Here's a diagram I find helpful of the arachidonic pathway and which drugs inhibit which parts of the pathway: https://files.mari.casa/aapathway.jpg

Thanks - this type of reply is what separates Reddit from HN

You can find this kind of reply on Reddit if you’re in the right subreddit. /r/science and /r/drugnerds come to mind as potential candidates.

Re: New insights into why aspirin works so well

#265
post #199

Earlier quoted context omitted.

I'm not sure that invalidates GP's point. Your comment is basically just repeating his premise. If we don't understand the why, we don't understand the how. We can spend years testing that "it works," but we're only testing for a specific outcome and checking for specific risks. Without understanding the how or why, we have little way of knowing what we don't know.

Ground rhino horn and tiger penis don't have measurable results, sure it's not ideal we might not understand how aspirin does what it does, but at least we know that it does something. That's not even in the same ballpark as Chinese medicine so comparing them just for that reason is disingenuous. We don't test medicine for marketing, we test them for results. If homeopathy and Chinese medicine would teach us one thin…

Indeed, chinese medicine and homeopathy show us that spending a dime on testing that you could be spending on marketing instead is always a waste

Re: New insights into why aspirin works so well

#266
post #199

Earlier quoted context omitted.

I'm not sure that invalidates GP's point. Your comment is basically just repeating his premise. If we don't understand the why, we don't understand the how. We can spend years testing that "it works," but we're only testing for a specific outcome and checking for specific risks. Without understanding the how or why, we have little way of knowing what we don't know.

Ground rhino horn and tiger penis don't have measurable results, sure it's not ideal we might not understand how aspirin does what it does, but at least we know that it does something. That's not even in the same ballpark as Chinese medicine so comparing them just for that reason is disingenuous. We don't test medicine for marketing, we test them for results. If homeopathy and Chinese medicine would teach us one thin…

Not only that, but it's based on a very certain, but false, idea of why it "works".

Re: New insights into why aspirin works so well

#267

Earlier quoted context omitted.

> taking fever reducers when sick significantly increases how long it takes to recover I’ve also heard this, and always wondered whether it was true or a myth. I really have no idea. Any chance you have a reputable source?

Would you turn off your CPU fan when it spins to 100% from opening ${electron app} just because the sound was annoying?

Suppressing the fever is more like significantly undervolting your CPU because the heat output of your gaming computer makes your room uncomfortably warm. Sure your room isn't too hot anymore, but the CPU needed that power to do useful work, and it's possible it won't be able to keep up with what you need anymore.

Re: New insights into why aspirin works so well

#268
post #46

Earlier quoted context omitted.

> how dare the other guy suggest alternatives that do not work

[flagged]

You get that there are a world of treatment options for chronic pain between "Mainline heroin most days" and "Take lots of CBD", right?

Re: New insights into why aspirin works so well

#269

Aspirin has been a life changer for long Covid. The other painkillers make symptoms 10x worse. Many people wonder if aspirin anti platelet/blood thinning capabilities is helping breakup microclots which brings relief. There’s also a thing called nattokinase that apparently has similar properties to aspirin and is being studied for heart disease. It has been shown to break down blood clots and even degrade the spike p…

Along these lines, you might have even better luck with serrapeptase, which breaks down fibrin protein.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8265778/

These are known tissue plasminogen activators.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5553328/table/t...

Re: New insights into why aspirin works so well

#270
post #157

Earlier quoted context omitted.

I guess theres always a caveat, but fevers can get too high and go for too long, in which case reducing the fever might be a good idea. But if it gets to that point, you should be working with a doctor to make those decisions.

This is a misnomer though. Your body will not make the fever too high in the case of fighting a virus, so danger is low. From an evolutionary standpoint this would make no sense. For a bacterial infection I think the chance of going to the danger zone is higher though. Typically it's better to just let the fever ride when you have a virus, unless it's making you you so uncomfortable you can't rest/sleep.

Well, brain damage may not be a detriment to some.

Btw, "misnomer" doesn't mean what you think it means.

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