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New insights into why aspirin works so well

eurekalert.org

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Re: New insights into why aspirin works so well

#241

Post by jamal-kumar »

DoreenMichele wrote: post #28
jamal-kumar wrote: post #25

Earlier quoted context omitted.

There's something like a downward spiral into hell that is opiates which starts with low doses like what you're on and escalates into worse and worse bullshit because you're not even trying to treat the underlying inflammation before masking the pain with opiates, and then the movement the pain is trying to prevent you from doing happens anyways and you just end up with more damage. I'm telling you these alternatives…

They did not ask for health advice from random internet strangers. Trying to bully someone into following medical advice they didn't ask for is not cool.

I revel in how mad my mere suggestions made people here

Re: New insights into why aspirin works so well

#242

Post by lanstin »

hprotagonist wrote: post #177
INTPenis wrote: post #124

When you say in 2023 that they have "new insights" as to why a common over the counter drug works it really doesn't instill great confidence in pharma. Seems like we're still grinding up rhino horns and tiger penis and hoping for the best outcome, just that we do it with extensive testing now so we get a statistically acceptable outcome viable for marketing.

efficacy and safety are the benchmark targets for regulatory approval. mechanism of action isn’t even on the list. “it works, it won’t kill you faster than the thing it treats, we have no idea why” is totally legit. welcome to biology, the dance of control with non-engineered systems.

The dance of control with non-engineered systems. Nice summary. And the systems reuse hits for distinct purposes like mad. For a little while in lockdown I tried to understand the biology of ACE receptors and my god, I couldn’t even memorize all the different types and subtypes nor the tissues they were found in, much less what functions that might imply.

Re: New insights into why aspirin works so well

#243

Post by Broken_Hippo »

INTPenis wrote: post #124

When you say in 2023 that they have "new insights" as to why a common over the counter drug works it really doesn't instill great confidence in pharma. Seems like we're still grinding up rhino horns and tiger penis and hoping for the best outcome, just that we do it with extensive testing now so we get a statistically acceptable outcome viable for marketing.

"When you say in 2023 that they have "new insights" as to why a common over the counter drug works it really doesn't instill great confidence in pharm"

This isn't a problem with big pharma, but rather, an issue with your understanding of how little we know about medicine. We occasionally still find new body parts, and we've been dissecting bodies for centuries.

We don't cure some diseases because we don't know the reasons they happen, but find out some medicines that seem to help. Others, we don't cure simply because we don't know how to prevent them.

And this sort of thing isn't limited to medicine: We weren't sure the astronauts would survive. We did what we could to me reasonably sure, but... we weren't. This isn't new, nor is it contained to medicine. We've done a lot of things without understanding the underlying mechanisms.

Re: New insights into why aspirin works so well

#244

Post by mongol »

1MachineElf wrote: post #236

Today an allergist told me the random lip swelling I experience (angioterma) has been caused in many other patients by NSAIDs like Aspirin, Tylenol (acetaminophen), and a Alleve (naproxen sodium). I hate to think that's true, but apparently it is a studied phenomena: https://aacijournal.biomedcentral.com/articles/10.1186/1710-...

I also get reactions. My eyes get swollen. It works very well as painkiller though but I feel I must avoid it.

Re: New insights into why aspirin works so well

#245

Post by gumby »

IE6 wrote: post #207
thenerdhead wrote: post #171

Aspirin has been a life changer for long Covid. The other painkillers make symptoms 10x worse. Many people wonder if aspirin anti platelet/blood thinning capabilities is helping breakup microclots which brings relief. There’s also a thing called nattokinase that apparently has similar properties to aspirin and is being studied for heart disease. It has been shown to break down blood clots and even degrade the spike p…

Do you have any good literature on Aspirin and LC? Not a doubter, actually I have LC myself.

I was surprised to read recently that Metformin has been a helpful therapy for LC. It's also an old drug (not as old as Aspirin of course!) with a surprising number of therapeutic use cases.

Re: New insights into why aspirin works so well

#246

Post by yamazakiwi »

zabzonk wrote: post #31
jamal-kumar wrote: post #25

Earlier quoted context omitted.

There's something like a downward spiral into hell that is opiates which starts with low doses like what you're on and escalates into worse and worse bullshit because you're not even trying to treat the underlying inflammation before masking the pain with opiates, and then the movement the pain is trying to prevent you from doing happens anyways and you just end up with more damage. I'm telling you these alternatives…

believe me, i know all about pain, from experience. cannabis derived products are not going to do anything, and i have no idea what you were going on about with tumeric. the only real actual pain-killers are opioids.

You say only but I would say alcohol is decent at pain reduction in a lot of cases.

Re: New insights into why aspirin works so well

#247

Post by gumby »

INTPenis wrote: post #124

When you say in 2023 that they have "new insights" as to why a common over the counter drug works it really doesn't instill great confidence in pharma. Seems like we're still grinding up rhino horns and tiger penis and hoping for the best outcome, just that we do it with extensive testing now so we get a statistically acceptable outcome viable for marketing.

> When you say in 2023 that they have "new insights" as to why a common over the counter drug works it really doesn't instill great confidence in pharma.

When you read of new work on friction in 2023 does it reduce your confidence in the field of physics?

It is true that we are still just scratching at the surface of biology, but incrementally we (humanity) are making progress every day. It's not engineering.

Re: New insights into why aspirin works so well

#248

Post by gumby »

mistrial9 wrote: post #227
fundatus wrote: post #222

Earlier quoted context omitted.

> except thousands of common herbal remedies are replaced by patent medicine with legal controls, because $MONEY Except they are not being replaced? Just like in the good old days™ you can still get out and collect the herbs you're looking for. It's just that nowadays we know that component X of a herbal remedy actually does the job so you just buy that in tablet form (or whatever) instead eating of the whole thing.

> get out and collect the herbs you're looking for. on the small chance that you are not being sarcastic.. Our city here has >300,000 residents.. and most cities nearby are paved. Where do the herbs come from ?

People will collect them for you and sell them in bottles in the shops, you know.

Re: New insights into why aspirin works so well

#249

Post by John23832 »

mistrial9 wrote: post #227
fundatus wrote: post #222

Earlier quoted context omitted.

> except thousands of common herbal remedies are replaced by patent medicine with legal controls, because $MONEY Except they are not being replaced? Just like in the good old days™ you can still get out and collect the herbs you're looking for. It's just that nowadays we know that component X of a herbal remedy actually does the job so you just buy that in tablet form (or whatever) instead eating of the whole thing.

> get out and collect the herbs you're looking for. on the small chance that you are not being sarcastic.. Our city here has >300,000 residents.. and most cities nearby are paved. Where do the herbs come from ?

They're still not being replaced... Not sure what you're getting at.

If there is a flower in the Amazon with "heal all" properties, but it's only found in the Amazon, do you fault the company that creates a pill form and sells it in France?

Big Pharma has it's problems, but it's done wonders for the availability of medicines for the vast majority of people on Earth.

Re: New insights into why aspirin works so well

#250

Post by [deleted] »

gumby wrote: post #247
INTPenis wrote: post #124

When you say in 2023 that they have "new insights" as to why a common over the counter drug works it really doesn't instill great confidence in pharma. Seems like we're still grinding up rhino horns and tiger penis and hoping for the best outcome, just that we do it with extensive testing now so we get a statistically acceptable outcome viable for marketing.

> When you say in 2023 that they have "new insights" as to why a common over the counter drug works it really doesn't instill great confidence in pharma. When you read of new work on friction in 2023 does it reduce your confidence in the field of physics? It is true that we are still just scratching at the surface of biology, but incrementally we (humanity) are making progress every day. It's not engineering.

[deleted]
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