Comment taken from Reddit:
Actually if you read the ruling, it states that they have a recording of a conversation, transcribed in the ruling, where she basically admits what they are looking for is on the laptop. They then use existing Vermont case law where some perv had child porn on his laptop that an officer and ICE agent witnessed before getting locked out of the laptop. The case law the judge quotes says "where the existence and location of the documents are known to the government, no constitutional rights are touched, because these matters are a foregone conclusion." So basically the established case law they are using is where they already knew for sure the perv's laptop contained the evidence they are looking for because they saw it firsthand. In this lady's case, they know the laptop contains the documents they are looking for because they have her recorded saying so. The judge states as much in the ruling: "There is little question here but that the government knows of the existence and location of the computer’s files."
So as much as people are freaking out about this, I don't think this is definitive case law that says the 5th amendment doesn't ever apply. The Vermont case and now the Colorado case both hinge on the government knowing that what they are looking for is on the encrypted drive because they saw it and have an admission to it respectively. This is what the ruling states in my opinion.
The 5th amendment may still apply if they don't know for sure the encrypted drive contains what they are looking for, that is to say they never saw the contents nor you admitted to it containing the contents which they seek.