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Vitamin D supplementation and incident dementia

alz-journals.onlinelibrary.wiley.com

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Re: Vitamin D supplementation and incident dementia

#71

Post by _yb2s »

Aldipower wrote: post #33
fshbbdssbbgdd wrote: post #17

Like all studies into Vitamin D supplementation that aren’t randomized controlled trials, it’s very hard to tell apart cause and effect. Vitamin D naturally occurs when people go outside and get exposed to the sun, and going outside is correlated with all sorts of healthy traits. Also, publicity of the association of vitamin D with good health has led people who care about their health or who have access to good medi…

> Vitamin D naturally occurs when people go outside and get exposed to the sun, ... Not sure where you are living? If I go outside in winter (+2 months around) I need gloves, cap, scarf. Literally only a little portion of my face gets some sunlight until 5pm. Then it is dark! I live in Germany! So, this isn't an argument for a lot of people in cold countries or dark countries. Mostly both.. Exposing to the sun is ver…

Our bodies can store enough to make it through the winter if you are replete at the beginning.

Re: Vitamin D supplementation and incident dementia

#72

Post by mtlmtlmtlmtl »

GoToRO wrote: post #70
mtlmtlmtlmtl wrote: post #38

Earlier quoted context omitted.

Easiest to just take it in the form of fish oil capsules. Though you can't take larger doses like this, because fish oil also contains vitamin A which can be toxic in higher doses.

What problem is it solving? curious. later edit: ahh, oil, fat :)

Vitamin D is fat soluble like you said. Vitamin D dissolved in fatty oils from fish should be more easily absorbed, which means you could take it without a meal.

Also, the omega-3 fatty acids in fish oil are good for you, and it provides vitamin A and E.

It's a win-win-win-win!

Re: Vitamin D supplementation and incident dementia

#73

Post by hobo_mark »

moremetadata wrote: post #65
fshbbdssbbgdd wrote: post #17

Like all studies into Vitamin D supplementation that aren’t randomized controlled trials, it’s very hard to tell apart cause and effect. Vitamin D naturally occurs when people go outside and get exposed to the sun, and going outside is correlated with all sorts of healthy traits. Also, publicity of the association of vitamin D with good health has led people who care about their health or who have access to good medi…

>Vitamin D naturally occurs when people go outside and get exposed to the sun, and going outside is correlated with all sorts of healthy traits. And also increases the risk of skin cancer and Parkinson's!

You what? Sun gives you Parkinson's now?

Re: Vitamin D supplementation and incident dementia

#74

Post by Ezku »

Perhaps not many in this audience are dealing with having to mitigate the prospect of dementia. How about something close to the horizon for almost all of us?

> Vitamin D deficiency can cause over‐activation of the pulmonary renin‐angiotensin system (RAS) leading to the respiratory syndrome. RAS is regulated in part at least by angiotensin‐converting enzyme 2 (ACE2), which also acts as a primary receptor for SARS‐CoV‐2 entry into the cells. Hence, vitamin D deficiency can exacerbate COVID‐19, via its effects on ACE2.

— Vitamin D and COVID-19: Role of ACE2, age, gender, and ethnicity. J Med Virol. 2021 https://pubmed.ncbi.nlm.nih.gov/33990955/

> Angiotensin-converting enzyme 2 (ACE2), a part of the renin-angiotensin system (RAS), serves as the major entry point into cells for SARS-CoV-2 which attaches to human ACE2, thereby reducing the expression of ACE2 and causing lung injury and pneumonia. Vitamin D, a fat-soluble-vitamin, is a negative endocrine RAS modulator and inhibits renin expression and generation… Therefore, targeting the unbalanced RAS and ACE2 down-regulation with vitamin D in SARS-CoV-2 infection is a potential therapeutic approach to combat COVID-19.

— A brief review of interplay between vitamin D and angiotensin-converting enzyme 2: Implications for a potential treatment for COVID-19. Rev Med Virol. 2020 https://pubmed.ncbi.nlm.nih.gov/32584474/

Here’s a caveat to remember when taking vitamin D:

> Majority of the adults are deficient in both vitamin D and magnesium but continue to go unrecognized … Mg is essential in the metabolism of vitamin D, and taking large doses of vitamin D can induce severe depletion of Mg. Adequate magnesium supplementation should be considered as an important aspect of vitamin D therapy.

— Magnesium Supplementation in Vitamin D Deficiency. Am J Ther. 2019 https://pubmed.ncbi.nlm.nih.gov/28471760/

Re: Vitamin D supplementation and incident dementia

#75

Post by Obscurity4340 »

bilsbie wrote: post #51

I’d like to supplement but every time I take one I get muscle cramps. I suppose it’s just pulling all the magnesium out of my body or something? I tried magnesium supplements with it but it didn’t help. Maybe 5000IU is just too much?

It is important to co-administer Vitamin K-12 with the D due to its effects on calcium.

Re: Vitamin D supplementation and incident dementia

#76

Post by tharkun__ »

adriand wrote: post #56
version_five wrote: post #50

Earlier quoted context omitted.

I had thought that it was possible to get vitamin D from moderate sun exposure in the winter and went looking for info to refute your post. Turns out you are right and I was wrong: https://www.nytimes.com/2022/12/06/well/live/vitamin-d-defic... People living above the 37th parallel, basically the tropics, may not be getting enough in the winter, because the sun isn't strong enough to provide it.

It’s brutal, I live near Toronto and not only is the winter sun quite weak but sunny days are quite uncommon. Almost every day is grey and overcast. Combine that with short daylight periods and winter becomes quite the gruelling challenge in terms of mental health especially.

Weeeellll :)

Toronto Harborfront Center is at 43.6397877,-79.3836877,17.12z according to Google. If I look for the southern most part of Germany, that seems to be Oberstdorf which is at 47.3997083,10.2805651,14.08z ;)

Or in other words, Germany in terms of natural sun light exposure in winter is way worse than Toronto. In fact, in Germany its dark much earlier and sun comes up much later for longer. I hear cloud cover is very comparable to the Toronto weather you describe so aptly.

One of the most populated areas of Germany is at around 51.5, if we wanted to "guess" where aldipower might be from. Going mostly straight up from Toronto, if you want to hit "civilization" at that level, that's Waskaganish, QC or Moosonee, ON a bit more south, right on our beautiful Hudson Bay.

I complain less and less about our beautiful country, the more I compare it w/ the world ;)

Re: Vitamin D supplementation and incident dementia

#77

Post by Rury »

version_five wrote: post #50
Aldipower wrote: post #33

Earlier quoted context omitted.

> Vitamin D naturally occurs when people go outside and get exposed to the sun, ... Not sure where you are living? If I go outside in winter (+2 months around) I need gloves, cap, scarf. Literally only a little portion of my face gets some sunlight until 5pm. Then it is dark! I live in Germany! So, this isn't an argument for a lot of people in cold countries or dark countries. Mostly both.. Exposing to the sun is ver…

I had thought that it was possible to get vitamin D from moderate sun exposure in the winter and went looking for info to refute your post. Turns out you are right and I was wrong: https://www.nytimes.com/2022/12/06/well/live/vitamin-d-defic... People living above the 37th parallel, basically the tropics, may not be getting enough in the winter, because the sun isn't strong enough to provide it.

Yes, this is the reason people further from the tropics tend to have lighter skin and are more likely to have genetics allowing for lactose tolerance throughout life. They're natural adaptations by the body, in response to being in an environment which sunlight (and therefore vitamin D) is more scarce.

Re: Vitamin D supplementation and incident dementia

#78

Post by iopq »

_yb2s wrote: post #71
Aldipower wrote: post #33

Earlier quoted context omitted.

> Vitamin D naturally occurs when people go outside and get exposed to the sun, ... Not sure where you are living? If I go outside in winter (+2 months around) I need gloves, cap, scarf. Literally only a little portion of my face gets some sunlight until 5pm. Then it is dark! I live in Germany! So, this isn't an argument for a lot of people in cold countries or dark countries. Mostly both.. Exposing to the sun is ver…

Our bodies can store enough to make it through the winter if you are replete at the beginning.

That, of course, assumes you don't wear sunscreen during the summer/fall, which I do

Re: Vitamin D supplementation and incident dementia

#79

Post by adshouts »

netfortius wrote: post #13

I've been taking 1000 IUs daily, for the last 20 years, skipping summers (during which I would attempt sun exposure), while continuously being within acceptable medians for my age. I sure hope what I am typing now makes sense :-)

I’d get a cold at least once a year and the flu every few years. I started taking 5K IUs of D3 daily in 2019 and haven't had a cold or flu since then.

Re: Vitamin D supplementation and incident dementia

#80

Post by adriand »

tharkun__ wrote: post #76
adriand wrote: post #56

Earlier quoted context omitted.

It’s brutal, I live near Toronto and not only is the winter sun quite weak but sunny days are quite uncommon. Almost every day is grey and overcast. Combine that with short daylight periods and winter becomes quite the gruelling challenge in terms of mental health especially.

Weeeellll :) Toronto Harborfront Center is at 43.6397877,-79.3836877,17.12z according to Google. If I look for the southern most part of Germany, that seems to be Oberstdorf which is at 47.3997083,10.2805651,14.08z ;) Or in other words, Germany in terms of natural sun light exposure in winter is way worse than Toronto. In fact, in Germany its dark much earlier and sun comes up much later for longer. I hear cloud cove…

Wow, TIL. That’s kind of nuts, I just looked at latitude lines because I was sure you had to be wrong but it looks like where I live (which is actually Hamilton) is the same latitude as northern Italy. In fact, it’s almost exactly the same as Florence, where the forecasted highs over the next week are in mid- to high-teens (C). We have a blizzard and most days next week the high is 1 degree. I honestly didn’t realize how much climate is not strictly determined by latitude!
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