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Vitamin D supplementation and incident dementia

alz-journals.onlinelibrary.wiley.com

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Re: Vitamin D supplementation and incident dementia

#2
This is a very neutral headline. But for the tl;dr crowd:

> Across all formulations, vitamin D exposure was associated with significantly longer dementia-free survival and lower dementia incidence rate than no exposure (hazard ratio = 0.60, 95% confidence interval: 0.55–0.65). The effect of vitamin D on incidence rate differed significantly across the strata of sex, cognitive status, and APOE ε4 status.

Re: Vitamin D supplementation and incident dementia

#5
post #3

Hey people who follow the science: As an “indoor human”, how much should I be taking? (TIA!)

Up to 4,000 IU is generally recognized as safe. If you take a multivitamin, there is some in that that you should subtract.

https://www.health.harvard.edu/staying-healthy/how-much-vita...

Re: Vitamin D supplementation and incident dementia

#6
post #3

Hey people who follow the science: As an “indoor human”, how much should I be taking? (TIA!)

Test your current level, ideally in the winter or early spring. If it’s low or low-normal[1], start with 2000 IU/day. Wait 6-9 months, test again. If it’s still low, increase to 4000 IU/day.

The comments on this submission have more: https://news.ycombinator.com/item?id=34634977#34635562

[1] If it’s really low, see a doctor

Re: Vitamin D supplementation and incident dementia

#7
post #3

Hey people who follow the science: As an “indoor human”, how much should I be taking? (TIA!)

I wouldn’t say I have followed the science but my doc prescribed 2000 IUs daily and it definitely makes a noticeable difference in a gloomy winter

What kind of a difference have you noticed? I also take 2000 IUs, but I haven't noticed any significant difference in how I feel since I've started taking it.

Re: Vitamin D supplementation and incident dementia

#8
post #3

Hey people who follow the science: As an “indoor human”, how much should I be taking? (TIA!)

Some might not like this answer but the best course of action is still some sun exposure. As for the actual answer, someone correct me if I'm wrong but there there are multiple 'variants' of vit. D and the vast majority of "vit D" supplements most likely don't include the complete formula (which is arguably the best way in order to also assimilate it "fully"). The daily recommended dose is fine unless you're deficient.

Re: Vitamin D supplementation and incident dementia

#9
post #8
post #3

Hey people who follow the science: As an “indoor human”, how much should I be taking? (TIA!)

Some might not like this answer but the best course of action is still some sun exposure. As for the actual answer, someone correct me if I'm wrong but there there are multiple 'variants' of vit. D and the vast majority of "vit D" supplements most likely don't include the complete formula (which is arguably the best way in order to also assimilate it "fully"). The daily recommended dose is fine unless you're deficien…

There are places where it is impossible to get the recommended amount of sun exposure, even if you were to spend most of your day outside.

Re: Vitamin D supplementation and incident dementia

#10
post #3

Hey people who follow the science: As an “indoor human”, how much should I be taking? (TIA!)

I would advise taking a K2 MK7 supplement with D3, or get a supplement that contains both. Personally, I take one capsule a day that contains both 3000IU of D3 and 100μg of K2 MK7.

D3 by itself can cause high calcium levels, to the point of toxicity in very high doses. The K2 moves the calcium from the blood to bones.

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