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Poor sleep drove me insane, and my long path to recovery

writing.samsonhu.com

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Re: Poor sleep drove me insane, and my long path to recovery

#331

Post by FollowingTheDao »

aantix wrote: post #324
FollowingTheDao wrote: post #320

Earlier quoted context omitted.

Did this help? https://jamanetwork.com/journals/jama/fullarticle/202502 CYP1A2 also metabolizes cholesterol so caffeine will increase your heart attack risk. And this is why genetics are crucial in understanding your dietary risks.

So for those that slowly metabolize caffeine, would it be prudent to take a statin?

Probably not. It might be that you need the cholesterol to produce more steroid hormones. Statins not only stop you from making cholesterol but also CoQ10 as well.

It would probably be best to keep a check on your oxidative stress because that is what most likely triggers heart disease, not just cholesterol alone.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6769522/

Re: Poor sleep drove me insane, and my long path to recovery

#332

Post by Wagthesam »

elric wrote: post #327
Wagthesam wrote: post #295

Earlier quoted context omitted.

A sleep test diagnoses sleep apnea. DISE can give clues, but Dr Kasey Li is against it saying it gives a lot of false positives from his experience. Home test + polysomnography is his standard, along with using his experience to review your CBCT scans

False positives? If you snore, you snore. All DISE is going to do is help figure out what's causing the snoring. I don't know this Dr Li, but you're making them sound like they're part of a cult.

I defer to his expertise for a lot as he's considered one of the top experts in sleep apnea surgery in the world. He's had more cases for example on MMA than aggregate studies in the literature

He considers DISE to show collapse that would not normally occur. Because under dise you are heavily sedated. Like after drinking alcohol, the airway is not the same as a normal state.

Re: Poor sleep drove me insane, and my long path to recovery

#333

Post by genman »

monroewalker wrote: post #42

Thank you for sharing! Skimmed for now, but saving this to read later. I've had a history as well of never getting good sleep so I'm curious to see what your experience was and the steps you've taken. A few things I've done that have helped a bunch: - Using BreatheRight nasal strips every night - Latex earplugs ("Mack's Pillow Soft Silicone Earplugs"). I could never sleep with foam earplugs in my ears but these are g…

Getting a CO2 monitor was eye opening. We had very bad ventilation in our rental bed room and we invested considerably to get a very good ventilation solution when we got our house.

Re: Poor sleep drove me insane, and my long path to recovery

#334

Post by bandanah12 »

Wagthesam wrote: post #286
gwbas1c wrote: post #175

I found out I had sleep apnea mostly due to coincidence. Eventually I got jaw surgery to fix it, but there is a surprising anecdote: Shortly after I started using a CPAP, at a networking event I met someone who worked at a mental health clinic, and he told me that many of their patients with schizophrenia had a pressure setting of 18 or 19 bars. Apparently disturbed sleep can cause some rather severe mental illness.…

Late stage untreated UARS is similar to a catatonic existence. I think Christian Guilleminault described this population in his research. Thankfully even my experience did not get to this point

can you share the paper or article?

Re: Poor sleep drove me insane, and my long path to recovery

#335

Post by theonething »

wahnfrieden wrote: post #315
theonething wrote: post #313

Earlier quoted context omitted.

That's awesome. You're living my dream. The App Store is so competitive nowadays though. Any advice for newcomers? (without giving away your trade secrets). How did you come up with your app ideas?

I will start blogging in the open about this stuff because I have enough moat I target language learning but that was just enough to escape wage labor and have irons burning now. My ideas all come from various hobby interests I know well, and focusing on problems that in some way help other people aspire toward making money themselves. I also find strategies where I can scale without costs or high maintenance needs (…

Thank you. Is there an email list I can get on or something else I can check to see when you debut your blog?

Re: Poor sleep drove me insane, and my long path to recovery

#336

Post by bluSCALE4 »

monroewalker wrote: post #97
bluSCALE4 wrote: post #86

Earlier quoted context omitted.

I bought an Aranet recently and at night, it can go as high as 1600. I figured not wasn't as important at night but this article has me wondering. I will say that I've been going to the office 2-3 days a week and I've been sleeping a whole lot better lately. I don't recall when horrific sleep started but I'm fairly certain it was pre pandemic.

That sounds pretty high! Have you made any changes or do you still have it hit 1600 while you're sleeping? I was never able to find a good source for what levels to target, but I did come across this study [1] which claims to have measured a difference in cognitive function the next day for people who slept with avg c02 levels at 835 ppm vs the group at 660 ppm. I don't have the background to judge the legitimacy of…

I did replace my water heater with an electric one. I got this after that so who knows that the baseline used to be but I do have some ideas for more improvements. I may open the window a smidge to see if it makes a difference. A little hesitant since I have a newborn and it being winter and all. I'm trying to get Home Assistant to work with Bluetooth so I can link the two and turn on the bathroom fan.

Re: Poor sleep drove me insane, and my long path to recovery

#337

Post by pfannkuchen »

genman wrote: post #333
monroewalker wrote: post #42

Thank you for sharing! Skimmed for now, but saving this to read later. I've had a history as well of never getting good sleep so I'm curious to see what your experience was and the steps you've taken. A few things I've done that have helped a bunch: - Using BreatheRight nasal strips every night - Latex earplugs ("Mack's Pillow Soft Silicone Earplugs"). I could never sleep with foam earplugs in my ears but these are g…

Getting a CO2 monitor was eye opening. We had very bad ventilation in our rental bed room and we invested considerably to get a very good ventilation solution when we got our house.

What did you do?

Re: Poor sleep drove me insane, and my long path to recovery

#338

Post by monroewalker »

bluSCALE4 wrote: post #336
monroewalker wrote: post #97

Earlier quoted context omitted.

That sounds pretty high! Have you made any changes or do you still have it hit 1600 while you're sleeping? I was never able to find a good source for what levels to target, but I did come across this study [1] which claims to have measured a difference in cognitive function the next day for people who slept with avg c02 levels at 835 ppm vs the group at 660 ppm. I don't have the background to judge the legitimacy of…

I did replace my water heater with an electric one. I got this after that so who knows that the baseline used to be but I do have some ideas for more improvements. I may open the window a smidge to see if it makes a difference. A little hesitant since I have a newborn and it being winter and all. I'm trying to get Home Assistant to work with Bluetooth so I can link the two and turn on the bathroom fan.

One thing I came across while looking into c02 and ventilation was the recommendation to sleep with the door closed but window open for fire safety concerns: https://fsri.org/programs/close-before-you-doze. Something else to consider when settling on a setup

Re: Poor sleep drove me insane, and my long path to recovery

#339

Post by pfannkuchen »

DrThunder wrote: post #325
theonething wrote: post #311

Earlier quoted context omitted.

Thank you. This and GP's comment are refreshing to hear. All I see on the news about lack of sleep is doom and gloom. According to them, I'm totally fucked in a myriad of ways and it's too late for me since I've held a sleep deficit for so long now. Yeah, I understand lack of adequate sleep is bad for me, no shit. I'm doing the best I can and you're not helping. (addressing those sleep gloom and doom people)

I just had a kid. I came to the conclusion that if sleep deprivation was a detrimental as some of these people say then our species would have become extinct long ago. Our bodies are able to cope just fine on lack of sleep and recover down the road. Is it ideal? No, but I've surprised myself with how functional I can actually be with lack of sleep. I just say, hey that sucks, and then move on with my day.

Doesn’t this assume that sleep was similarly disrupted in the ancestral environment? Do we know that it was? Is it possible that it wasn’t?

Re: Poor sleep drove me insane, and my long path to recovery

#340

Post by ahstilde »

Wagthesam wrote: post #317
ahstilde wrote: post #316

It's interesting he mentions allergy shots. It sounds like his doctor didn't know about sublingual immunotherapy. It's similarly effective, but much less disruptive to the ongoings of daily life. Disclaimer: I run Wyndly ( https://www.wyndly.com/ ) a YC-backed startup that uses sublingual immunotherapy, among other allergy treatments, to help people breathe better.

I know about SLIT, but from my research most allergists don't mix in enough to make it comparable to shots. From studies I read you need 30-100x the dose of shots taken in monthly aggregate for it to be comparable. For example Odactra which is fda approved for dust mites is 30x the concentration of a monthly maintenance dose. I am allergic to almost everything, so I imagine it will be too costly to treat properly Als…

I agree with you -- the protocol is what matters. Your concern about the dosage applies to allergy shots, too, however.

At Wyndly, our protocol follows the academic research. I'll work on making this more explicit.

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