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Gut microbes could drive brain disorders

nature.com

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Re: Gut microbes could drive brain disorders

#82

Post by user395929935 »

11235813213455 wrote: post #21

I had schizophrenia and still have, but it's now not as prevalent after years of eating mostly vegetable, raw, and very ripe, fermented sometimes (like when peppers, onions, garlic for example are getting soft, people usually call them "rotten", but I prefer them like this actually, there can even be some bacteria formation on it, it doesn't matter). That with regular walking/running outdoor helped me so much. A typi…

Thank you for being open and sharing your experience. I appreciate you sharing your dietary expertise. I’m currently in the middle of Dr. Hyman’s UltraMind solution book and plan to add your suggestions to my diet. Personally I’m diagnosed with Schizoaffective disorder, and thought to add my experience as well. I ate junk for over 20 years growing up which didn’t help my brain/gut.

In addition to foods, two things that have helped me tremendously and have not given me the horrendous side effects of Antipsychotics are what I’m currently taking:

- Sarcosine 1 gram/day (dissolved in water) -- An amino acid that occurs naturally in foods such as egg yolks, turkey, and legumes, and can be bought as a dietary supplement.

- BPC-157 250mcg ever other day (enteric coating capsule) -- Which is composed of 15 amino acids, is a partial sequence of body protection compound (BPC) that is discovered in and isolated from human gastric juice

(Don’t blindly take my advice or change medicines without supervision, I make no guarantees on efficacy or safety.)

I have a good deal of research notes on what I’ve found on why they work but hacker news has smarter people than I and would love to hear from others. The brain gut connection is massively important.

Re: Gut microbes could drive brain disorders

#83

Post by samstave »

samstave wrote: post #26
11235813213455 wrote: post #21

I had schizophrenia and still have, but it's now not as prevalent after years of eating mostly vegetable, raw, and very ripe, fermented sometimes (like when peppers, onions, garlic for example are getting soft, people usually call them "rotten", but I prefer them like this actually, there can even be some bacteria formation on it, it doesn't matter). That with regular walking/running outdoor helped me so much. A typi…

Forgive the following joke, however, I feel you may like it: Spoken dead-pan style in Steven Wright's voice: - "I used to have schizophrenia, but they still have it"

I've updated this joke just now, but they still haven't

-

Spoken as the magnanimous Stephen Wright the comedian ;

"We used to have schizophrenia, but now... only to them."

-

"schizophrenics used to make jokes to their friends... but now, only to us."

"I used to be afraid of schizophrenic's comments, but now I just dont know where they are coming from"

"A schizophrenic once told me this, and this is true, a Mayan saying is In'Laketch - which means "Iam another yourself" -- and this was my best friend.

So I had only one response.

"I don't even know who you are any more"

Re: Gut microbes could drive brain disorders

#84

Post by user395929935 »

11235813213455 wrote: post #42
poisonarena wrote: post #28

Earlier quoted context omitted.

how do you know it is from eating vegetables and not just dialed down with time or other factors?

The psychiatrists I saw years ago said it will only get worse with time, and he gave me an antipsychotics treatment, I tried 4 months then stopped because my brain was so disconnected, I felt like a vegetable, I couldn't even write or talk properly. Antidepressant or lighter drugs didn't have much effect. So I tried to cure myself with other ways (a bit coincidentally with food)

It sounds like you’re getting all the nutrients needed to create gastric juices.

Here’s a link to a study: https://journals.lww.com/nrronline/Fulltext/2022/03000/Penta...

As someone with Schizoaffective this works for me. Going to start eating more veggies!

Re: Gut microbes could drive brain disorders

#87

Post by samstave »

Animatronio wrote: post #61
samstave wrote: post #26

Earlier quoted context omitted.

Forgive the following joke, however, I feel you may like it: Spoken dead-pan style in Steven Wright's voice: - "I used to have schizophrenia, but they still have it"

Steven Wright the stand-up comedian or Steven Wright the serial killer?

Comedian

Re: Gut microbes could drive brain disorders

#88

Post by user395929935 »

user395929935 wrote: post #82
11235813213455 wrote: post #21

I had schizophrenia and still have, but it's now not as prevalent after years of eating mostly vegetable, raw, and very ripe, fermented sometimes (like when peppers, onions, garlic for example are getting soft, people usually call them "rotten", but I prefer them like this actually, there can even be some bacteria formation on it, it doesn't matter). That with regular walking/running outdoor helped me so much. A typi…

Thank you for being open and sharing your experience. I appreciate you sharing your dietary expertise. I’m currently in the middle of Dr. Hyman’s UltraMind solution book and plan to add your suggestions to my diet. Personally I’m diagnosed with Schizoaffective disorder, and thought to add my experience as well. I ate junk for over 20 years growing up which didn’t help my brain/gut. In addition to foods, two things th…

Here's a few studies on both for reference:

Sarcosine:

https://pubchem.ncbi.nlm.nih.gov/compound/Sarcosine

The NMDA Receptor and Schizophrenia: From Pathophysiology to Treatment https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5518924/

Efficacy and cognitive effect of sarcosine (N-methylglycine) in patients with schizophrenia: A systematic review and meta-analysis of double-blind randomised controlled trials https://pubmed.ncbi.nlm.nih.gov/32122256/

Two grams of sarcosine in schizophrenia - is it too much? A potential role of glutamate-serotonin interaction https://pubmed.ncbi.nlm.nih.gov/24523591/

BPC-157:

Pentadecapeptide BPC 157 and the central nervous system https://journals.lww.com/nrronline/Fulltext/2022/03000/Penta...

Brain-gut Axis and Pentadecapeptide BPC 157: Theoretical and Practical Implications https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5333585/

A novel pentadecapeptide, BPC 157, blocks the stereotypy produced acutely by amphetamine and the development of haloperidol-induced supersensitivity to amphetamine https://pubmed.ncbi.nlm.nih.gov/9547930/

BPC 157, L-NAME, L-Arginine, NO-Relation, in the Suited Rat Ketamine Models Resembling "Negative-Like" Symptoms of Schizophrenia https://pubmed.ncbi.nlm.nih.gov/35884767/

Gastric pentadecapeptide BPC 157 effective against serotonin syndrome in rats https://pubmed.ncbi.nlm.nih.gov/15840402/

Pentadecapeptide BPC 157 attenuates chronic amphetamine-induced behavior disturbances https://pubmed.ncbi.nlm.nih.gov/11978191/

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