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Diabetes drug Mounjaro was available at $25/month, then increased to $1k/month

independent.co.uk

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Re: Diabetes drug Mounjaro was available at $25/month, then increased to $1k/month

#211

Post by HyperSane »

eyelidlessness wrote: post #193
HyperSane wrote: post #162

Earlier quoted context omitted.

With very few exceptions obesity is simply the result of eating more calories than needed for a long time. Very obese people eat a LOT of food. 10,000 calories/day for years is not uncommon.

From high school through nearly all of my adult life I’ve been obese. For the last several years my weight has barely fluctuated, but it’s fluctuated between caution about being underweight and a few pounds “overweight” that barely even count. I’ve eaten almost exactly the same the whole time. The two factors which changed: - I take ADHD meds, amphetamines, which are appetite suppressants. They haven’t made me eat le…

Have you every reached 600 pounds? 800? If not why do you think that is? It is because you simply didn't eat enough food to do so.

Re: Diabetes drug Mounjaro was available at $25/month, then increased to $1k/month

#212

Post by kilgnad »

HyperSane wrote: post #208
kilgnad wrote: post #196

Earlier quoted context omitted.

1 in 3 people in the US are obese. It is not just about eating more calories than needed for a long time. The story is much much more complicated then that given that 1 in 3 people are obese. It's like saying an overdose on heroin is simply someone doing too much heroin at a time.

"It is not just about eating more calories than needed for a long time." Yes it is. It really is as simple as that, people just don't want to hear it. Historically food was scarce that it was nearly impossible to sustain a calorie surplus long enough to get fat. But some people did, that is why the rich used to be called "fat cats" but now calories are so cheap and delicious and lifestyles are so sedentary that it is…

>Yes it is. It really is as simple as that, people just don't want to hear it. Historically food was scarce that it was nearly impossible to sustain a calorie surplus long enough to get fat. But some people did, that is why the rich used to be called "fat cats" but now calories are so cheap and delicious and lifestyles are so sedentary that it is very easy for almost anyone to sustain the caloric surplus needed to become very fat.

I'm skinny so I'm unbiased. There is nothing I "don't" want to hear because I'm literally not affected by it. Thus, I assure you I have more information than you. Read below:

https://www.theatlantic.com/health/archive/2015/09/why-it-wa...

Your reasoning is on anthropological timescales, which while technically true, doesn't explain why people were still skinny in the 80s and before. There was an actual turning point AFTER the 80s... A huge shift in weight gain where MODERN and well-fed people suddenly got heavier. Something happened with the food supply starting with the US.

We only have correlative studies that match a number of things with the sudden change in weight. Thus no causative confirmation on the exact source. Our educated guess says that it has to do with processed foods. Processed foods streamline calorie absorption to unnatural levels leading to unnatural weight gain.

The article above mentions a number of other factors that I think are possible.

Re: Diabetes drug Mounjaro was available at $25/month, then increased to $1k/month

#213

Post by kilgnad »

HyperSane wrote: post #210
kilgnad wrote: post #197

Earlier quoted context omitted.

No. Absorption rates are different. Liquefied fat of the same calories translates to more fat then plant with the same calories. That's just an extreme example. The real culprit is processed foods.

The difference should not be enough to be the difference from a body fat percentage of 15% to 80%.

https://www.theatlantic.com/health/archive/2015/09/why-it-wa...

You don't know that.

Re: Diabetes drug Mounjaro was available at $25/month, then increased to $1k/month

#214

Post by Animats »

bedast wrote: post #36

Mounjaro is not an obesity drug. It's a type 2 diabetes drug. Do not call it an obesity drug. The headline is editorialized. The linked article's headline: The ‘next Ozempic’ became a social media sensation. Then everything changed The coupon didn't go away. The coupon's terms changed. I'm using the coupon now. Because I have type 2 diabetes. The coupon changed because people were using it to get the drug for off-lab…

> Mounjaro is not an obesity drug. It's a type 2 diabetes drug. Do not call it an obesity drug.

It's in round 2 of phase 3 clinical testing as an obesity drug, and will probably have full approval this summer.

Re: Diabetes drug Mounjaro was available at $25/month, then increased to $1k/month

#215

Post by msrenee »

icelancer wrote: post #166
msrenee wrote: post #64

Earlier quoted context omitted.

Are they the solution to obesity? I'm curious as to whether the weight stays off long term. 10 or more years at least or else it's just another bandaid. What we need is better access to nutritious food that doesn't take up so much of folk's scant downtime and tight income. I understand there's lots of reasons people are obese that aren't just laziness, but the drug doesn't solve those either. They're still not gettin…

People saying that you have to be on X drug forever to solve your problem as if it's some silver bullet argument think.... what exactly about Type I diabetics who need to inject insulin every day, forever, to solve their problem?

I get where you're coming from and want to clarify that my issue is not that you may have to stay on it for the rest of your life. I'm concerned that even while on the drug, your body could get accustomed to it, and you'd end up eating the same as before taking the drug. This happens a lot with bariatric surgery. I realize that that's due to the elasticity of the stomach, but the body adapts and with many medications that have weight loss as a side effect, your body eventually sorts itself out and you start gaining weight again.

Re: Diabetes drug Mounjaro was available at $25/month, then increased to $1k/month

#216

Post by msrenee »

drewbug01 wrote: post #149
msrenee wrote: post #64

Earlier quoted context omitted.

Are they the solution to obesity? I'm curious as to whether the weight stays off long term. 10 or more years at least or else it's just another bandaid. What we need is better access to nutritious food that doesn't take up so much of folk's scant downtime and tight income. I understand there's lots of reasons people are obese that aren't just laziness, but the drug doesn't solve those either. They're still not gettin…

> 10 or more years at least or else it's just another bandaid. I wonder what the long-term health outcomes would be between two groups: one group that was obese the whole time, and another group whose obesity was delayed by ten years. I suspect the latter group would end up having fewer negative health outcomes over the course of their life - 10 years of essentially “reduced wear and tear” on different systems in the…

I expect they would as well. However, I was replying to a comment that claimed this drug or something similar could be the solution to obesity and I have serious doubts about that. An improvement in health and longevity, even if it's substantial, is not the same as a solution. For example, if we discovered a drug that delayed severe illness/death from cancer for 5 years, it certainly wouldn't be called a solution to cancer. It would be amazing for sure, but that doesn't solve the cancer problem.

Re: Diabetes drug Mounjaro was available at $25/month, then increased to $1k/month

#217

Post by BoorishBears »

walnutclosefarm wrote: post #85
bedast wrote: post #36

Mounjaro is not an obesity drug. It's a type 2 diabetes drug. Do not call it an obesity drug. The headline is editorialized. The linked article's headline: The ‘next Ozempic’ became a social media sensation. Then everything changed The coupon didn't go away. The coupon's terms changed. I'm using the coupon now. Because I have type 2 diabetes. The coupon changed because people were using it to get the drug for off-lab…

> Mounjaro is not an obesity drug. It's a type 2 diabetes drug. Do not call it an obesity drug This is an absurd argument. It's a drug. It has specific metabolic affects in humans that are valuable to people's health, among which are the control of blood glucose levels, and control of appetite and nutrient uptake, leading to loss of excess weight. That it is currently labeled only for Type 2 diabetes is a marketing d…

Sometimes you need to examine subtext a little closer.

Obviously this person is (reasonably) upset* that off-label use is muscling out on-label use, when the two uses are of two very different classes.

Their issue isn't just the fact that the common vocabulary has switched to focusing on weight loss, it's the general shift in where the supply is going that's accompanies said shift in vocabulary

Being overweight is a serious health issue, but Type 2 diabetics were using it in a way that was much more acutely pressing, with much fewer alternatives. It's not hard to understand why diabetics would feel upset/threatened by a secondary off-label use of such a different class.

* I read it as upset as the situation, not at those who are overweight to be clear

Re: Diabetes drug Mounjaro was available at $25/month, then increased to $1k/month

#218

Post by somehnguy »

bedast wrote: post #73
wonderwonder wrote: post #58

Earlier quoted context omitted.

"Diabetes patients think people with obesity are stealing their drug, as it’s currently only approved for the treatment of T2D (though FDA approval for the treatment of obesity may come as soon as this summer.) People with obesity are angry that obesity isn’t recognized as a disease. And users who can’t afford it say they’ve been abandoned by Big Pharma." Always amazing when an article is verified in real time

It's weird for anyone to "feel abandoned by Big Pharma" when you abused a coupon to get a drug for off-label use, and terms were changed to match its on-label use. Especially when there's versions of these drugs with on-label use for weight loss.

Why should anyone need to use a coupon in the first place? Just charge a reasonable price, don’t make people jump through hoops for medicine.

Re: Diabetes drug Mounjaro was available at $25/month, then increased to $1k/month

#219

Post by msrenee »

Spivak wrote: post #35
lm28469 wrote: post #17

Earlier quoted context omitted.

> who won’t regulate the drug market And the food industry, the real root cause of all of this

Saying food is the cause of obesity is boiling down the visible aggregate effect of a million different things into one big cause. I eat pretty much nothing but garbage food -- pizza, wings, burgers, subs: just salt and grease. And I went from 220 to 120 and stayed there doing it. It's a meme at this point that when we go to restaurants with friends it's the skinny people ordering apps and burgers and the overweight…

I can put down enough calories in a meal to make a garbage truck blush. It's not necessarily that skinny people (or somewhat squishy people who carry it discreetly in my case) don't eat all of their food. It can also be that when you see me down a trashcan lid of nachos, it's my treat for the week (or two) and I accommodate for that in my normal habits.
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