Live data from Hacker News

Zantac’s maker kept quiet about cancer risks for 40 years

fiercepharma.com

71–80 of 134 posts

Re: Zantac’s maker kept quiet about cancer risks for 40 years

#71

> Intense public scrutiny on Zantac started in 2019, when an online pharmacy found high levels of a likely carcinogen in the drug and its generics. And the linked article says: > Valisure discovered the link of Zantac and its generics to the carcinogen NDMA during its routine testing of every batch of every medication, and first notified the FDA of its initial findings in June of 2019. On September 13th, Valisure fil…

I've ordered medication from them because they test to make sure that there's no impurities. It's not that much more expensive and I would gladly pay to know there's no extra chemicals in there that could give me cancer.

every single pharmaceutical has impurities. some grow over time (chemistry does not stop) and those are the ones to worry about.

Re: Zantac’s maker kept quiet about cancer risks for 40 years

#73

Earlier quoted context omitted.

Even something as simple as telling people to store the bottle in the refrigerator...

if you have to sell your OTC medication in a refrigerator, your sales will drop a lot. It's not somewhere people think to look, and the impression is that it's perishable. Which people can appreciate for something like a steak, but not their "safe and usual" medications.

I would gladly refrigerate it if it meant I could still use it. I've never had another acid reducer that works as well for me as Zantac.

I have so many major health problems that quite frankly I'll probably be dead before I could get cancer from this stuff.

Re: Zantac’s maker kept quiet about cancer risks for 40 years

#74
post #17

Earlier quoted context omitted.

> "What's my recourse?" A lawsuit, like the thousands mentioned in the article.

How would I have known to file a lawsuit about something when I had no knowledge of the situation for years?

That’s the beauty of it

Re: Zantac’s maker kept quiet about cancer risks for 40 years

#75

Interesting counterpoint is that a judge recently lambasted the entire body of scientific evidence linking ranitidine (Zantac) to cancer and tossed all the cases. https://www.chemistryworld.com/news/judge-dismisses-ranitidi... If they could find a way to ensure the impurity didn’t exist, I would certainly buy ranitidine again. I found it was the most effective antacid for me.

Judges: people who are famously experts in pharmacology

[deleted]

Re: Zantac’s maker kept quiet about cancer risks for 40 years

#76

Earlier quoted context omitted.

Except... you still shouldn't use it because it's an anticolinergic linked to dementia in old age, just like Benedryl.

Thank you, this led me down a really interesting rabbithole about age-related dementia and anticholinergic substances. Best tidbits: 1: "Anticholinergic Accumulation: A Slumbering Interaction between Drugs and Food Supplements" https://onlinelibrary.wiley.com/doi/full/10.1111/bcpt.12437 2: Chart of medicines with high ACB scores (higher is worse) - you will recognize some of these, such as allergy and anti-nausea med…

Ugh, imodium too.

Re: Zantac’s maker kept quiet about cancer risks for 40 years

#77

Earlier quoted context omitted.

if you have to sell your OTC medication in a refrigerator, your sales will drop a lot. It's not somewhere people think to look, and the impression is that it's perishable. Which people can appreciate for something like a steak, but not their "safe and usual" medications.

I would gladly refrigerate it if it meant I could still use it. I've never had another acid reducer that works as well for me as Zantac. I have so many major health problems that quite frankly I'll probably be dead before I could get cancer from this stuff.

It's still manufactured overseas. There are shady-but-legit websites that sell it.

Nothing else on the market compares.

Re: Zantac’s maker kept quiet about cancer risks for 40 years

#78

Earlier quoted context omitted.

I would gladly refrigerate it if it meant I could still use it. I've never had another acid reducer that works as well for me as Zantac. I have so many major health problems that quite frankly I'll probably be dead before I could get cancer from this stuff.

It's still manufactured overseas. There are shady-but-legit websites that sell it. Nothing else on the market compares.

I store all medicines (prescription and some OTC) in the fridge. So it’s the first place I look. They ARE perishable.

Re: Zantac’s maker kept quiet about cancer risks for 40 years

#79

Interesting counterpoint is that a judge recently lambasted the entire body of scientific evidence linking ranitidine (Zantac) to cancer and tossed all the cases. https://www.chemistryworld.com/news/judge-dismisses-ranitidi... If they could find a way to ensure the impurity didn’t exist, I would certainly buy ranitidine again. I found it was the most effective antacid for me.

Judges: people who are famously experts in pharmacology

[deleted]

Re: Zantac’s maker kept quiet about cancer risks for 40 years

#80
post #64

Earlier quoted context omitted.

Note that they sold their pharmacy business, but claim to be continuing the testing for the new owner: "The company has since sold its pharmacy operation to concentrate only on quality and safety testing. It continues to test products for the pharmacy’s new owner, Medly, along with other business clients looking to certify for their customers that what they’re buying is legitimate." From https://www.consumerreports.o…

And Medly filed for bankruptcy in December, and sold it's digital assets to Walgreens as of last week (and is now shut down completely). https://digitalhealth.modernhealthcare.com/finance/medly-sel...

All those mergers, including with my go-to for supplements, Pharmaca, in such a short time. How did it turn into such a dumpster fire so quickly? I feel like there's got to be a story.
Post reply on HN