I appreciate that, and also appreciate that absolutely nobody has the ability to understand the complete workings of a modern computer -- from the OS to the assembly, to the micro-architecture of the silicon, memory, networking, etc.
Even just having an expert level in any one of those pieces is a serious undertaking.
Similarly, albeit to a vastly greater degree, nobody entirely understands the multitude of cellular machinery, their interactions, their chemical processes, or encoding, in any species. Even 50% in a single organism is probably lifetimes away.
So yeah, biohackers are equal parts arrogant, reckless, and stupid... Life should be given appropriate respect, and it's hard to see how "DIY bioengineering" doesn't spit in the face of that.
Yet I would hate to see a future where people are barred from their own physiology, their own code. Removing your right to mess with your own life just seems authoritarian and oppressive to me, at the most fundamental level.
Editing OTHER people's genome should be highly regulated, as well as anything that has the potential to reproduce outside a controlled environment. This of course includes microbes within your own body, viral infections, gut bacteria, etc.
But I think people not being able to edit their own code is horrifically dystopian. Should probably be a requirement that you also have your reproductive rights removed too though, since your descendants wouldn't have a say.