Earlier quoted context omitted.
You can't parse DNA with regex.
Not with that attitude.
If stackoverflow taught me anything, you will only summon Zalgo by trying.
Why does the SARS-Cov2 genome end in aaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa? (2020)
81–90 of 125 posts
Re: Why does the SARS-Cov2 genome end in aaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa? (2020)
#82The top answer at the link explains it best: Good observation! The 3' poly(A) tail is actually a very common feature of positive-strand RNA viruses, including coronaviruses and picornaviruses. For coronaviruses in particular, we know that the poly(A) tail is required for replication, functioning in conjunction with the 3' untranslated region (UTR) as a cis-acting signal for negative strand synthesis and attachment to…
Can a drug target that sequence specifically?
Not if it's common to both viruses and human cells you can't.
Re: Why does the SARS-Cov2 genome end in aaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa? (2020)
#83Re: Why does the SARS-Cov2 genome end in aaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa? (2020)
#84It amazes me that the genome is only 29k long. If you were to write a computer virus now, it probably wouldn't be that short, let alone something that can infect and kill millions of people.
Re: Why does the SARS-Cov2 genome end in aaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa? (2020)
#85Maybe the scientist who made it died before he finished? ATTACGAAAAAAAAAAAAAAAAAAAAAAAA……
Proof that god is dead?
Re: Why does the SARS-Cov2 genome end in aaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa? (2020)
#86Maybe the scientist who made it died before he finished? ATTACGAAAAAAAAAAAAAAAAAAAAAAAA……
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Re: Why does the SARS-Cov2 genome end in aaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa? (2020)
#87The top answer at the link explains it best: Good observation! The 3' poly(A) tail is actually a very common feature of positive-strand RNA viruses, including coronaviruses and picornaviruses. For coronaviruses in particular, we know that the poly(A) tail is required for replication, functioning in conjunction with the 3' untranslated region (UTR) as a cis-acting signal for negative strand synthesis and attachment to…
Interestingly, vaccines also have a long repeating sequence at the end. It provides molecular stability.
Found a wikipedia article describing it:
Re: Why does the SARS-Cov2 genome end in aaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa? (2020)
#88Very interesting. I first wondered how nature can randomly generate such a pattern, and then realized we are just falling for our "built in" pattern recognition: it would feel much more "natural" for the stop sequence to be the encoding of some specific protein without any clearly recognizable pattern... But it would actually be more unlikely to appear/survive mutation than "any long-enough sequence of A".
I also like how it is established that this has an effect on replication, but that as far as I understand we do not understand the underlying process. Humbling.
Re: Why does the SARS-Cov2 genome end in aaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa? (2020)
#89[deleted]
Re: Why does the SARS-Cov2 genome end in aaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa? (2020)
#90[flagged]