Live data from Hacker News

Scientists discover receptor that blocks Covid-19 infection

sydney.edu.au

121–130 of 167 posts

Re: Scientists discover receptor that blocks Covid-19 infection

#121

Earlier quoted context omitted.

I think kids are likely to catch asymptomatic or extremely mild Covid annually. That’ll potentially be 4-5% of their educational time. Kids of wealthy families with parents with flexible jobs will be fine. Not every kid is in a home situation like that.

You have to look at both sides of the intervention, right? Like if isolating that kid doesn't prevent any further infections, then it isn't doing any good. If isolating them for 3 days prevents a couple other kids from getting infected, it's less clear. Using PCR tests to evaluate clearance doesn't make sense though, since they can be positive if there are fragments but no viable virus.

> Using PCR tests to evaluate clearance doesn't make sense though, since they can be positive if there are fragments but no viable virus.

It's a cost and time issue. The cost of filtering snot, inoculating a culture dish of infectable cells with the filtered snot, waiting a couple of days for the cells to show signs of infection (cell swelling or bursting), and then running a PCR test on the cells in the culture dish. With high enough throughput you could probably do this for $50 or there about, and maybe three days, to verify whether they were technically still infected three days ago.

Re: Scientists discover receptor that blocks Covid-19 infection

#122

Earlier quoted context omitted.

I believe that the technocratic culture of US medicine is standing in the way of research on intranasal vaccines. What you consistently hear from medical professionals is, "we have this proven technology, it works, the objections to it are irrational, can we please just be sensible?" So far, so good… (I'm a bit of a technocrat myself) But why are people so afraid of vaccines in particular? There are all sorts of argu…

People are scared of needles is incredibly dismissive and likely intentionally insulting. People aren't afraid of the needles; they're concerned about the unknown impacts of what's being injected through the needles. While needle phobia exists, it's very small percentage of those who didn't want the mystery chemical cocktail pushed by those who openly told countless "noble" lies. The vast majority of these people hav…

None of this address his main point of 'why the vaccines when pharma has does the same thing a bunch of times to other things yet people still take tylenol (which is demonstrably toxic and causes serious illness and death all the time)'?

The same people who refuse the vaccine take unknown substances in 'supplements' which have no regulation at all. It makes no sense. Explain it.

Re: Scientists discover receptor that blocks Covid-19 infection

#123

> “For me, as an immunologist, the fact that there's this natural immune receptor that we didn't know about, that's lining our lungs and blocks and controls virus, that's crazy interesting. So natural immunity is a real thing.

It was a wildly popular view here on Hacker New at the height of covid hysteria that even those with natural immunity should still be forced to get whatever injections the governments deemed necessary because "it makes the paperwork easier to track if everyone is required and there is ZERO RISK! ABSOLUTELY ZERO RISK!!!!"

There are still a few holdouts here on naturally acquired immunity being inferior to being given the injections but most of them hinge on a theoretical fraction of a percentage increase in potential protection from having both or upset at the prospect that someone might lie about having had covid previously and use it as an excuse to not get injected. Mostly those who rushed headfirst into mindless authoritarianism are trying to pretend they never participated in the hysteria.

Re: Scientists discover receptor that blocks Covid-19 infection

#124

Earlier quoted context omitted.

People are scared of needles is incredibly dismissive and likely intentionally insulting. People aren't afraid of the needles; they're concerned about the unknown impacts of what's being injected through the needles. While needle phobia exists, it's very small percentage of those who didn't want the mystery chemical cocktail pushed by those who openly told countless "noble" lies. The vast majority of these people hav…

None of this address his main point of 'why the vaccines when pharma has does the same thing a bunch of times to other things yet people still take tylenol (which is demonstrably toxic and causes serious illness and death all the time)'? The same people who refuse the vaccine take unknown substances in 'supplements' which have no regulation at all. It makes no sense. Explain it.

I can explain it. Tylenol has been around since 1955 and is only demonstrably toxic in overdoses. The mrna based vaccines have been only used for the past couple years, hence long term side effects are unknown.

Not everyone who refuses the vaccine takes supplements. Your comparison is like saying "why don't you take this research chemical ('molly'), you smoke cannabis already".

Re: Scientists discover receptor that blocks Covid-19 infection

#125

Earlier quoted context omitted.

Sarbecoronaviruses are a subset of betacoronaviruses. And I seriously doubt we have a comprehensive sequence database of all sarbecoronaviruses. If furin cleavage sites are present in about 21% of alpha- and betacoronaviruses I would expect they would also be present in a minority of most lineages within these clades. "Furin cleavage sites are also found in certain bat-origin MERS-like merbecovirises" > For such a sp…

I suppose if people were inserting furin cleavage sites specifically into the Sars-CoV-2 precursor sequence, then they might generate a series of variants to see which one worked best when it came to results of infectivity tests in human cell lines? Regarding bat lineages and host viruses, this 2019 paper seems to indicate that the other betacoronavirus lineage with the furin site, the Merbecovirus, has a different b…

> I suppose if people were inserting furin cleavage sites specifically into the Sars-CoV-2 precursor sequence, then they might generate a series of variants to see which one worked best when it came to results of infectivity tests in human cell lines?

This makes sense.

I think here's the most relevant quote from that article: "So far, no betaCoVs from the sub-genus Merbecovirus have been detected in bats of suborder Yinpterochiroptera."

While the paper does mention one member of Yangochiroptera (Chaerephon plicatus) that has been discovered infected with sarbecoviruses, it looks like there's little room for infectious overlap of merbecoviruses and sarbecoviruses (which predominantly infect Yinpterochiropterans, at least as detected as of the paper publication).

So if the SARS-CoV-2 progenitor did get its furin cleavage site from a co-infection with a merbecovirus, this would have been a really rare event indeed. At least if the co-infection happened in a bat species, and not in another animal or a human who deals with bats.

Re: Scientists discover receptor that blocks Covid-19 infection

#126

Earlier quoted context omitted.

I believe that the technocratic culture of US medicine is standing in the way of research on intranasal vaccines. What you consistently hear from medical professionals is, "we have this proven technology, it works, the objections to it are irrational, can we please just be sensible?" So far, so good… (I'm a bit of a technocrat myself) But why are people so afraid of vaccines in particular? There are all sorts of argu…

People are scared of needles is incredibly dismissive and likely intentionally insulting. People aren't afraid of the needles; they're concerned about the unknown impacts of what's being injected through the needles. While needle phobia exists, it's very small percentage of those who didn't want the mystery chemical cocktail pushed by those who openly told countless "noble" lies. The vast majority of these people hav…

Because people also get freaked out about vaccines that have been proven to be safe and effective for over a hundred years.

Re: Scientists discover receptor that blocks Covid-19 infection

#127

Earlier quoted context omitted.

None of this address his main point of 'why the vaccines when pharma has does the same thing a bunch of times to other things yet people still take tylenol (which is demonstrably toxic and causes serious illness and death all the time)'? The same people who refuse the vaccine take unknown substances in 'supplements' which have no regulation at all. It makes no sense. Explain it.

I can explain it. Tylenol has been around since 1955 and is only demonstrably toxic in overdoses. The mrna based vaccines have been only used for the past couple years, hence long term side effects are unknown. Not everyone who refuses the vaccine takes supplements. Your comparison is like saying "why don't you take this research chemical ('molly'), you smoke cannabis already".

You didn't explain it, you explained around it.

I didn't ask why specifically about tylenol and supplements, I said explain why the outrage over vaccines and not other things.

Re: Scientists discover receptor that blocks Covid-19 infection

#128

Earlier quoted context omitted.

Honest question: why are you vaccinating while you also identify as low risk?

> Then I see old folks or one 30y/o woman in the supermarket wearing a mask, and I remember that this protects them too. I have a hard time believing that after 2 years of messaging about why people should take a vaccine that this is an “honest question”

> I have a hard time believing that after 2 years of messaging about why

You must have forgotten that they have been two years of communicational failures.

Re: Scientists discover receptor that blocks Covid-19 infection

#129
post #40

Earlier quoted context omitted.

I'm surprised we haven't gotten an intranasal vaccine before now. We've been talking about the issues with intramuscular vaccines in regards to mucosal immunity since the very beginning.

I believe that the technocratic culture of US medicine is standing in the way of research on intranasal vaccines. What you consistently hear from medical professionals is, "we have this proven technology, it works, the objections to it are irrational, can we please just be sensible?" So far, so good… (I'm a bit of a technocrat myself) But why are people so afraid of vaccines in particular? There are all sorts of argu…

> people are still happy to take whatever pills

Are you sure? Do you have numbers to show that (a critical number would be skeptical on one side and careless or trusting on the other)?

Re: Scientists discover receptor that blocks Covid-19 infection

#130

Earlier quoted context omitted.

People are scared of needles is incredibly dismissive and likely intentionally insulting. People aren't afraid of the needles; they're concerned about the unknown impacts of what's being injected through the needles. While needle phobia exists, it's very small percentage of those who didn't want the mystery chemical cocktail pushed by those who openly told countless "noble" lies. The vast majority of these people hav…

Because people also get freaked out about vaccines that have been proven to be safe and effective for over a hundred years.

> safe and effective

Those people maybe not being specialist cannot differentiate those remedies which are "safe" as the poster writes (which equals to "no risks or some risk of mild impact") and those which can have catastrophic impact in the relatively small set of the unlucky.

Post reply on HN